JIAN XU1,#, HAILONG GE1,#, CHEN CHAO1, FENG MO1, YU WANG1, DENGKUI ZHANG1, XIAOXIAO ZHENG2, LI ZHENG2, XUEMEI LU2, WEI CHEN2, QUN XU1,*, WEIXIN YU1,*
BIOCELL, Vol.46, No.6, pp. 1493-1503, 2022, DOI:10.32604/biocell.2022.016962
- 07 February 2022
Abstract Although sorafenib has been found to prolong the survival time of patients with hepatocellular carcinoma (HCC), sorafenib resistance remains an important challenge. Increasing studies have demonstrated that long noncoding RNAs (lncRNAs) contribute to drug resistance in a wide number of cancers. Human periodontal ligament stem cell (PDLSC) osteogenesis impairment-related lncRNA (POIR) is a recently defined lncRNA for which little is known regarding its function. Our study aimed to reveal the role of POIR in the development of HCC cell sorafenib resistance. The level of POIR expression in patients and tumor cells was examined by Reverse… More >
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