Yongtao Li*, Fanyu Chen*, Jiancheng Chu*, Chao Wu*, Yuan Li†, Heng Li†, Hongxin Ma*
Oncology Research, Vol.27, No.8, pp. 911-921, 2019, DOI:10.3727/096504019X15516966905337
Abstract To date, miR-148-3p and DNMT1–recombinant human runt-related transcription factor 3 (RUNX3) axis have
been linked to cell proliferation, migration, and invasion; however, their roles and relationships in human glioblastoma multiforme (GBM) are still not clear. Here we found that the expression of miR-148-3p in glioma
tissues was decreased compared with adjacent nontumor tissues and correlated with WHO grade, tumor size,
and prognosis as well as DNMT1 and RUNX3 expressions. Compared with NHA cells, the expression of miR-
148-3p in U87 and U251 cells was also downregulated and accompanied with upregulation of DNMT1 and
hypermethylation level of RUNX3 promoter region. miR-148-3p… More >
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