Shidan Liu1, Jiaxi Luan1, Yan Ding
Oncology Research, Vol.26, No.5, pp. 683-690, 2018, DOI:10.3727/096504017X14982585511252
Abstract This study aimed to investigate the role of miR-144-3p in pancreatic cancer (PC) carcinogenesis and to explore
the mechanism of its function in PC. miR-144-3p was downregulated in PC tissues and cells. miR-144-3p
overexpression significantly inhibited PC cell proliferation, migration, and invasion. FosB proto-oncogene,
AP-1 transcription factor subunit (FOSB) was a target gene of miR-144-3p. miR-144-3p could repress PC
cell proliferation, migration, and invasion by inhibiting the expression of FOSB. In conclusion, miR-144-3p
plays an important role in PC cell proliferation, migration, and invasion by targeting FOSB. miR-144-3p may
provide a new target for the More >
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