Lei Ou*, Dazhong Wang†, Han Zhang*, Qian Yu*, Fangfang Hua‡
Oncology Research, Vol.26, No.3, pp. 401-410, 2018, DOI:10.3727/096504017X15017209042610
Abstract MicroRNAs (miRNAs) play important roles in the carcinogenesis of cervical cancer. However, the expression
and underlying mechanisms of miRNA in cervical cancer progression remain unclear. In the present study, our
data showed that the expression of miR-138-5p was significantly downregulated in cervical cancer tissues, and
decreased expression of miR-138-5p was correlated with advanced FIGO stage, poor differentiation, lymph
node metastasis, and poor overall survival of cervical cancer patients. Function assays showed that overexpression of miR-138-5p reduced cervical cancer cell proliferation, arrested cells in the G0
/G1 phase, and induced
cell apoptosis in vitro. Remarkably, SIRT1 was More >
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