Pengcheng Zhang*, Fang Yang†, Qin Luo‡, Daxue Yan§, Shengrong Sun*
Oncology Research, Vol.27, No.2, pp. 253-260, 2019, DOI:10.3727/096504018X15242763477504
Abstract miR-1284 has been reported to inhibit tumor growth in some human cancers, including lung cancer, ovarian
cancer, and gastric cancer. Whether it regulates breast cancer progression remains elusive. In this study, we
found that miR-1284 was downregulated in breast cancer tissues and cell lines compared to normal control
cells. Moreover, we showed that overexpression of miR-1284 significantly inhibited the proliferation, migration, and invasion of breast cancer cells while promoting apoptosis. In terms of mechanism, we found that
transcription factor ZIC2 was a target of miR-1284 in breast cancer cells. Through the luciferase reporter assay,
we demonstrated their direct interaction. RT-qPCR… More >
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