Xinshan Cao*, Ling Xu†, Quanyuan Liu*, Lijuan Yang‡, Na Li§, Xiaoxiao Li*
Oncology Research, Vol.27, No.3, pp. 301-309, 2019, DOI:10.3727/096504018X15213058045841
Abstract Our study aimed to investigate the roles and possible regulatory mechanism of miR-1277 in the development
of hepatocellular carcinoma (HCC). HCC patients were identified from patients who were diagnosed with focal
liver lesions using magnetic resonance imaging (MRI). The expression levels of miR-1277 in the serum of
HCC patients and HepG2 cells were measured. Then miR-1277 mimic, miR-1277 inhibitor, or scramble RNA
was transfected into HepG2 cells. The effects of miR-1277 overexpression and suppression on HepG2 cell
proliferation, migration, and invasion were then investigated. Additionally, the expression levels of epithelial–
mesenchymal transition (EMT)-related markers, including… More >
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