Jian-Wei Wang, Xiao-Feng Wu, Xiao-Juan Gu, Xing-Hua Jiang
Oncology Research, Vol.27, No.9, pp. 979-986, 2019, DOI:10.3727/096504018X15336368805108
Abstract Cancer-associated fibroblasts (CAFs) play a predominant role in regulating tumor progression. Understanding
how CAFs communicate with osteosarcoma is crucial for developing novel approaches for osteosarcoma therapy. Exosomes are able to transmit messages between cells. In this study, we demonstrated that CAFs transfer
exosomes to osteosarcoma cells, which promotes osteosarcoma cell migration and invasion. Using a miRNA
microarray analysis, we identified 13 miRNAs that are significantly increased in exosomes derived from
cancer-associated fibroblasts (CAFs) and corresponding paracancer fibroblasts (PAFs). In vitro studies further validated that the levels of microRNA-1228 (miR-1228) were increased in CAFs, its secreted exosomes,
and in recipient osteosarcoma… More >
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