Xuesong Wang*, Yong Lin†, Lei Peng‡, Ruifu Sun*, Xiaojin Gong*, Jinlong Du*, Xiugong Zhang*
Oncology Research, Vol.26, No.6, pp. 933-940, 2018, DOI:10.3727/096504017X15144741233346
Abstract Osteosarcoma is one of the most aggressive malignancies with poor prognosis rates. Many studies have demonstrated that miRNAs were involved in osteosarcoma, but the role of miR-103a in osteosarcoma remains elusive.
In this study, we detected the expression levels of miR-103 in osteosarcoma and non-osteosarcoma tissues
and cell lines. The binding effect of miR-103 on p57 was detected by luciferase reporter assay. After altering
expressions of miR-103 or p57, viability, migration, invasion, and apoptosis of MG63 cells and expressions
of proteins related with the JNK/STAT and mTOR pathways were all detected. We found the higher More >
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