MARÍA J. RICO*1,2, PABLO MATAR*1,2, O. GRACIELA SCHAROVSKY1,3
BIOCELL, Vol.36, No.2, pp. 91-95, 2012, DOI:10.32604/biocell.2012.36.091
Abstract We have already shown that IL-10 plays an important role in immunosuppression and metastatic dissemination in the rat B-cell lymphoma L-TACB model. It was suggested that the up-regulation of IL10 production and IL-10 receptor (IL-10R) expression would be part of the transition from primary tumor to metastatic phenotype and that IL-10, besides its immunosuppressive activity, may act as a growth factor for metastatic L-TACB cells. The treatment of L-TACB-bearing rats with a single low-dose cyclophosphamide decreased IL-10 production, reverted immunosuppression and induced the immunologic rejection of tumor metastasis without any effect on primary tumor growth.… More >
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