Padmini Rangamani1,*
Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 22-22, 2019, DOI:10.32604/mcb.2019.08513
Abstract Endocytosis is the process of uptake of cargo and fluid from the extracellular space to inside the cell; defects in endo- cytosis contribute to a wide spectrum of diseases including cancer, neurodegeneration, and heart disease. Clathrin- mediated endocytosis (CME) is an archetypal example of a membrane deformation process where multiple variables such as pre-existing membrane curvature, membrane bending due to the protein machinery, membrane tension regulation, and actin-mediated forces govern the progression of vesiculation. My group has been working for the past few years on deciphering the biophysical determinants of CME using multiscale modeling. We… More >
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