MINGZHI LUO^#,*, CHANGYU SUN^#, JIA GUO, XIANGRONG ZHANG, JING ZHANG, XUANYU SHI, LEI LIU, YAN PAN, JINGJING LI, LINHONG DENG^*

BIOCELL, Vol.49, No.5, pp. 833-855, 2025, DOI:10.32604/biocell.2025.063869 - 27 May 2025

Abstract Background: Mechanical ventilation (MV) provides life support for patients with severe respiratory distress but can simultaneously cause ventilator-induced lung injury (VILI). However, due to a poor understanding of its mechanism, there is still a lack of effective remedies for the often-deadly VILI. Recent studies indicate that the stretch associated with MV can enhance the secretion of extracellular vesicles (EVs) and induce endoplasmic reticulum (ER) stress in airway smooth muscle cells (ASMCs), both of which can contribute to VILI. But whether MV-associated stretch enhances the secretion of EVs via ER stress in ASMCs as an underlying… More > Graphic Abstract

Giovanni Miracco^1,*, Francesco Nicoletti¹, Vittorio Ferraro², Dimitrios Kaliakatsos¹

Energy Engineering, Vol.122, No.3, pp. 861-883, 2025, DOI:10.32604/ee.2025.060750 - 07 March 2025

Abstract Indoor air quality (IAQ) is often overlooked, yet a poorly maintained environment can lead to significant health issues and reduced concentration and productivity in work or educational settings. This study presents an innovative control system for mechanical ventilation specifically designed for university classrooms, with the dual goal of enhancing IAQ and increasing energy efficiency. Two classrooms with distinct construction characteristics were analyzed: one with exterior walls and windows, and the other completely underground. For each classroom, a model was developed using DesignBuilder software, which was calibrated with experimental data regarding CO₂ concentration, temperature, and relative… More >

Lei Ren¹, Jing Hu², Mei Li^1,*, Ling Zhang², Jinyue Xia³

Computer Systems Science and Engineering, Vol.40, No.1, pp. 139-150, 2022, DOI:10.32604/csse.2022.018640 - 26 August 2021

Abstract Lung rehabilitation is safe and feasible, and it has positive benefits in weaning the machine as soon as possible, shortening the time of hospitalization and improving the prognosis of children with mechanical ventilation. However, at present, the traditional medical concept is deep-rooted, and doctors' understanding of early rehabilitation is inadequate. It is necessary to make in-depth exploration in the relevant guidelines and expert consensus to formulate standardized early rehabilitation diagnosis and treatment procedures and standards for mechanically ventilated children. In the paper, a structured graded lung rehabilitation program is constructed for children with mechanical ventilation… More >

Dongkai Shen^1,2,+, Qian Zhang¹, Yixuan Wang^1,*, Huiqing Ge^3,*, Zujin Luo^4,+

CMES-Computer Modeling in Engineering & Sciences, Vol.114, No.2, pp. 117-139, 2018, DOI:10.3970/cmes.2018.114.117

Abstract A pressure controlled mechanical ventilator with an automatic secretion clearance function can improve secretion clearance safely and efficiently. Studies on secretion clearance by pressure controlled systems show that these are suited for clinical applications. However, these studies are based on a single lung electric model and neglect the coupling between the two lungs. The research methods applied are too complex for the analysis of a multi-parameter system. In order to understand the functioning of the human respiratory system, this paper develops a dimensionless mathematical model of double-lung mechanical ventilation system with a secretion clearance function. More >

Ramana M. Pidaparti^∗,†, Kittisak Koombua^∗,‡

Molecular & Cellular Biomechanics, Vol.8, No.2, pp. 149-168, 2011, DOI:10.3970/mcb.2011.008.149

Abstract Better understanding of the stress/strain environment in airway tissues is very important in order to avoid lung injuries for patients undergoing mechanical ventilation for treatment of respiratory problems. Airway tissue strains responsible for stressing the lung's fiber network and rupturing the lung due to compliant airways are very difficult to measure experimentally. A computational model that incorporates the heterogeneity of the airways was developed to study the effects of airway tissue material properties on strain distributions within each layer of the airway wall. The geometry and boundary conditions of the tissue strain analysis were obtained More >

Kittisak Koombua^*, Ramana M. Pidaparti^∗,†,‡, P. Worth Longest^∗,‡, Kevin R. Ward^‡,§

Molecular & Cellular Biomechanics, Vol.6, No.4, pp. 203-216, 2009, DOI:10.3970/mcb.2009.006.203

Abstract Without proper knowledge of mechanical ventilation effects, physicians can aggravate an existing lung injury. A better understanding of the interaction between airflow and airway tissue during mechanical ventilation will be helpful to physicians so that they can provide appropriate ventilator parameters for intubated patients. In this study, a computational model incorporating the interactions between airflow and airway walls was developed to investigate the effects of airway tissue flexibility on airway pressure and stress. Two flow rates, 30 and 60 l/min, from mechanical ventilation were considered. The transient waveform was active inhalation with a constant flow… More >