Miao Huang¹, Maedeh Lotfi¹, Heyang Wang⁴, Hayley Sussman⁵, Kevin Connell¹, Quang Vo¹, Malisa Sarntinoranont¹, Hitomi Yamaguchi¹, Juan Guan², Xin Tang^1,3,*

The International Conference on Computational & Experimental Engineering and Sciences, Vol.32, No.1, pp. 1-2, 2024, DOI:10.32604/icces.2024.011130

Abstract Mechanotransduction, i.e., living cells sense and transduce mechanical forces into intracellular biochemical signaling and gene expression, is ubiquitous across diverse organisms. Increasing evidence suggests that mechanotransduction significantly influences cell functions and its mis-regulation is at the heart of various pathologies. A quantitative characterization of the relationship between mechanical forces and resulted mechanotransduction is pivotal in understanding the rules of life and innovating new therapeutic strategies [1-3]. However, while such relationship on the cell surface membrane and cytoskeleton have been well studied, little is known about whether/how mechanical forces applied on the cell interior nucleus (“headquarter… More >

Chenyu Liang¹, Bo Zeng², Mai Tanaka³, Andrea Kannita Noy¹, Matthew Barrett¹, Erica Hengartner¹, Abygale Cochrane⁴, Laura Garzon¹, Mitchell Litvinov⁵, Dietmar Siemann³, Xin Tang^1,3,*

The International Conference on Computational & Experimental Engineering and Sciences, Vol.32, No.1, pp. 1-2, 2024, DOI:10.32604/icces.2024.011126

Abstract Cancer accounts for 12.6% of all human deaths worldwide and 90% of cancer-related deaths are due to metastasis: the dissemination of invasive tumor cells from the primary tumors to other vital organs [1-3]. However, how these invasive tumor cells coordinate with each other to achieve the dissemination remains unclear. Recently we discovered that human tumor cells can initiate and transmit previously unknown long-distance (~100s m) intercellular biochemical waves in a microenvironment-mechanics-regulated manner. [4-5] In this presentation, we will present our new results on (1) the 2D/3D spatial-temporal characterization of the long-distance and the intra-/inter-cellular Ca²⁺ signals; More >

Bingbing ZHANG^{1, 2}, Ying ZHANG^{1, 2}, Xiaomei ZHANG^{1, 2}, Yonggang LV^{1, 2}

BIOCELL, Vol.42, No.1, pp. 17-24, 2018, DOI:10.32604/biocell.2018.06115

Abstract Mechanical microenvironment can strongly affect the metastatic efficiency of circulating tumor cells. However, the effect of suspension state on their extravasation and the mechanisms involved are still unclear. To explore the influence of suspension state on extravasation (including adhesion, spreading and transendothelial migration) of breast tumor cells and its relevant molecular mechanism, MDA-MB-231 cells were cultured on poly (2-hydroxyethyl methacrylate) coated 6-well plates to minic the suspension state. Suspension state promoted adhesion, spreading and transendothelial migration of MDA-MB-231 cells to EAhy926 endothelial cells (ECs) monolayer under both the static condition and 0.5 dyne/cm² flow shear stress More >