Ivan Breslavsky1,*, Giulio Franchini2, Francesco Giovanniello3, Ali Kassab3,4, Gerhard A. Holzapfel5,6, Marco Amabili1,3
The International Conference on Computational & Experimental Engineering and Sciences, Vol.34, No.1, pp. 1-1, 2025, DOI:10.32604/icces.2025.012190
Abstract Despite the critical role of vascular smooth muscle (VSM) activation in the biomechanics of human aortas, comprehensive experimental data and corresponding active material models remain limited. This study addresses this gap by presenting a detailed mechanical characterisation of human descending thoracic aortas under both passive and VSM-activated conditions.
Specimens were obtained from thirteen heart-beating donors. Mechanical testing was conducted within hours of explantation. VSM activation was induced using potassium chloride and noradrenaline, and both isometric and quasistatic stress–strain responses were measured in circumferential and longitudinal tissue strips.
Dynamic mechanical testing under physiologically relevant cyclic loading and More >
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