Erdong Shen¹, Ting Pan¹, Pan Guo¹, Ke Chen¹, Rui Xu¹, Mei Yang¹, Dahe Zhan¹, Fang Fang¹, Qinghui Wu^1,*, Jianbing Hu^1,*

The International Conference on Computational & Experimental Engineering and Sciences, Vol.30, No.4, pp. 1-3, 2024, DOI:10.32604/icces.2024.012772

Abstract Objective
This study investigates the synergistic effects of a novel multifunctional nanoparticle on gastric cancer treatment through photothermal therapy, chemotherapy, and immunotherapy.

Method
Synthesize hollow mesoporous Prussian blue nanoparticles and load them with luteolin. Use exosomes to encapsulate the nanoparticles and modify the surface of the targeted peptide GX1. Detect the morphology of nanoparticles using a nanoparticle size analyzer and transmission electron microscopy. Use Coomassie Brilliant Blue to detect the effect of extracellular vesicle encapsulation. Detect the thermal conversion efficiency of nanoparticles under specific laser irradiation through infrared and ultraviolet spectroscopy, as well as the release rate… More >

Fuxin Li¹, Enyan Chen¹, Xinxin Chen¹, Jingyu Jia¹, Hemin Wang¹, Jie Zhang¹, Jianrui Sun¹, Xin Li^1,2,3,*

Phyton-International Journal of Experimental Botany, Vol.93, No.8, pp. 2095-2113, 2024, DOI:10.32604/phyton.2024.054231 - 30 August 2024

Abstract Salt stress inhibits plant growth and affects the biosynthesis of its secondary metabolites. Flavonoids are natural compounds that possess many important biological activities, playing a significant role in the medicinal activity of Eucommia ulmoides (E. ulmoides). To investigate the mechanism by which salt stress affects the biosynthesis of flavonoids in E. ulmoides, a comprehensive analysis of metabolomics and transcriptomics was conducted. The results indicated that salt stress led to the wilting and darkening of E. ulmoides leaves, accompanied by a decrease in chlorophyll levels, and significantly induced malondialdehyde (MDA) and relative electrical conductivity. During salt stress, most metabolites in… More >

Teng Liu^*, Juan Xu^†, Hong Li Yan^‡, Feng Chun Cheng^*, Xi Jie Liu^*

Oncology Research, Vol.27, No.7, pp. 773-778, 2019, DOI:10.3727/096504018X15208986577685

Abstract Luteolin, which is found in plant foods, has a range of therapeutic applications. In order to examine the potential roles of luteolin in ovarian teratocarcinoma, the human ovarian teratocarcinoma cell line PA-1 was selected for functional experiments in vitro and in vivo. We demonstrated that luteolin inhibited the proliferation and colony formation of PA-1 cells in vitro. The flow cytometry results suggested that luteolin induced apoptosis of PA-1 cells in a dose-dependent manner. Immunofluorescence and qRT-PCR results showed that the expression of B-cell lymphoma-2 (Bcl-2) was decreased in luteolin-treated cells, whereas the expression of Bcl-2- More >

Hapon MV^1,2, JJ Boiteux^1,2, MA Fernández¹, G Lucero^1,2, MF Silva¹, PH Pizzuolo^1,2

Phyton-International Journal of Experimental Botany, Vol.86, pp. 270-277, 2017, DOI:10.32604/phyton.2017.86.270

Abstract The polyphagous plant pathogen Botrytis cinerea has the ability of growing fast under several conditions, and producing grey moulds in different plant tissues. Because of its adaptive plasticity, resistant strains have made difficult their chemical control. Therefore, new strategies of management and the use of natural compounds could be important control alternatives. The aim of this work was to study the potential value of four Argentine native plant extracts and some of its phenolic compounds as biodrugs on B. cinerea. Aqueous plant extracts of Larrea divaricata, Prosopis strombulifera, Tessaria absinthioides and Schinus molle var. areira, were used. The More >