MIN LIU^1,*, XIA LI², JUN LIU¹, YU LIU¹

BIOCELL, Vol.48, No.10, pp. 1475-1487, 2024, DOI:10.32604/biocell.2024.053227 - 02 October 2024

Abstract Background: Alveolar macrophage pyroptosis exacerbates inflammatory lung diseases, and tanshinone IIA is known for its anti-inflammatory properties. Thus, understanding how tanshinone IIA affects alveolar macrophage pyroptosis is essential. Methods: NR8383 cells were exposed to lipopolysaccharide (LPS) and adenosine triphosphate (ATP). We assessed cell viability, pyroptosis, and the expression of triggering receptors expressed on myeloid cells 2 (TREM2), p-β-catenin, β-catenin, and pyroptosis-related factors. We also examined the interaction between tanshinone IIA and TREM2. Results: Co-stimulation with LPS and ATP significantly reduced NR8383 cell viability, increased pyroptosis, and upregulated pyroptosis-associated factors. Treatment with tanshinone IIA mitigated these effects.… More >

Hassen Louati^1,2, Ali Louati^3,*, Elham Kariri³, Slim Bechikh²

CMES-Computer Modeling in Engineering & Sciences, Vol.138, No.3, pp. 2519-2547, 2024, DOI:10.32604/cmes.2023.030806 - 15 December 2023

Abstract Recent developments in Computer Vision have presented novel opportunities to tackle complex healthcare issues, particularly in the field of lung disease diagnosis. One promising avenue involves the use of chest X-Rays, which are commonly utilized in radiology. To fully exploit their potential, researchers have suggested utilizing deep learning methods to construct computer-aided diagnostic systems. However, constructing and compressing these systems presents a significant challenge, as it relies heavily on the expertise of data scientists. To tackle this issue, we propose an automated approach that utilizes an evolutionary algorithm (EA) to optimize the design and compression More >

AN-SOO JANG^*

BIOCELL, Vol.47, No.8, pp. 1703-1708, 2023, DOI:10.32604/biocell.2023.028975 - 28 August 2023

Abstract Exposure to air pollutants such as PM₁₀, PM_2.5, PM_0.1, O₃, CO, NO₂, and SO₂, and biological pollutants are important factors causing the evolution and furtherance of obstructive lung diseases (OLD), including asthma and chronic obstructive pulmonary disease (COPD). Asthma is the most frequent chronic inflammatory airway disease, characterized by breathlessness, wheezing, chest tightness, and cough, together with the presence of exaggerated expiratory airflow fluctuation that varies over time. COPD is a heterogeneous lung condition characterized by chronic respiratory symptoms such as dyspnea, cough, expectoration, and/or exacerbations due to abnormalities of the airways and/or alveoli that cause persistent, often… More >

J. Prabakaran^1,*, P. Selvaraj²

Computer Systems Science and Engineering, Vol.46, No.2, pp. 2141-2157, 2023, DOI:10.32604/csse.2023.034210 - 09 February 2023

Abstract In healthcare systems, the Internet of Things (IoT) innovation and development approached new ways to evaluate patient data. A cloud-based platform tends to process data generated by IoT medical devices instead of high storage, and computational hardware. In this paper, an intelligent healthcare system has been proposed for the prediction and severity analysis of lung disease from chest computer tomography (CT) images of patients with pneumonia, Covid-19, tuberculosis (TB), and cancer. Firstly, the CT images are captured and transmitted to the fog node through IoT devices. In the fog node, the image gets modified into… More >

Yurananatul Mangalmurti, Naruemon Wattanapongsakorn^*

Intelligent Automation & Soft Computing, Vol.34, No.2, pp. 733-752, 2022, DOI:10.32604/iasc.2022.025073 - 03 May 2022

Abstract This paper presents effective techniques for automatic detection/classification of COVID-19 and other lung diseases using machine learning, including deep learning with convolutional neural networks (CNN) and classical machine learning techniques. We had access to a large number of chest X-ray images to use as input data. The data contains various categories including COVID-19, Pneumonia, Pneumothorax, Atelectasis, and Normal (without disease). In addition, chest X-ray images with many findings (abnormalities and diseases) from the National Institutes of Health (NIH) was also considered. Our deep learning approach used a CNN architecture with VGG16 and VGG19 models which… More >

Mujeeb Ur Rehman^1,*, Maha Driss^2,3, Abdukodir Khakimov⁴, Sohail Khalid¹

CMC-Computers, Materials & Continua, Vol.72, No.3, pp. 5681-5697, 2022, DOI:10.32604/cmc.2022.025840 - 21 April 2022

Abstract Lungs are a vital human body organ, and different Obstructive Lung Diseases (OLD) such as asthma, bronchitis, or lung cancer are caused by shortcomings within the lungs. Therefore, early diagnosis of OLD is crucial for such patients suffering from OLD since, after early diagnosis, breathing exercises and medical precautions can effectively improve their health state. A secure non-invasive early diagnosis of OLD is a primordial need, and in this context, digital image processing supported by Artificial Intelligence (AI) techniques is reliable and widely used in the medical field, especially for improving early disease diagnosis. Hence,… More >

Kazuhiro Yamamoto^*, Takeshi Ioroi^*, Kazuaki Shinomiya^†, Ayaka Yoshida^*, Kenichi Harada^‡, Masato Fujisawa^‡, Tomohiro Omura^*, Yasuaki Ikemi^§, Shunsaku Nakagawa^§, Atsushi Yonezawa^§, Osamu Ogawa^¶, Kazuo Matsubara^§, Takuya Iwamoto^#, Kohei Nishikawa^**, Sayaka Hayashi^††, Daichi Tohara^††, Yoji Murakami^‡‡, Takanobu Motoshima^‡‡, Hirofumi Jono^††, Ikuko Yano^*§

Oncology Research, Vol.29, No.1, pp. 11-23, 2021, DOI:10.3727/096504022X16418911579334

Abstract We evaluated the association of signal transducer and activator of transcription 3 (STAT3) polymorphisms with the incidence of mammalian target of rapamycin (mTOR) inhibitor-induced interstitial lung disease (ILD) in patients with renal cell carcinoma (RCC). We also used lung-derived cell lines to investigate the mechanisms of this association. Japanese patients with metastatic RCC who were treated with mTOR inhibitors were genotyped for the STAT3 polymorphism, rs4796793 (−1697C/G). We evaluated the association of the STAT3 genotype with the incidence of ILD and therapeutic outcome. In the 57 patients included in the primary analysis, the ILD rate… More >

Katie E. Cohen¹, Matthew W. Buelow¹, Jennifer Dixon¹, Ruta Brazauskas², Scott B. Cohen³, Michael G. Earing^1,3, Salil Ginde¹

Congenital Heart Disease, Vol.12, No.4, pp. 435-440, 2017, DOI:10.1111/chd.12470

Abstract Objective: Abnormal lung function characterized by a reduced forced vital capacity (FVC) is common in adults with repaired tetralogy of Fallot (TOF) and is associated with previous thoracotomies and sternotomies. The impact of abnormal lung function on clinical outcomes in adult patients with repaired TOF is unclear. The aim of this study was to determine the impact of abnormal lung function on the outcome of hospitalization and death in adults with repaired TOF when analyzed with other traditional cardiac risk factors.
Design: Retrospective study of adults with repaired TOF, who underwent spirometry between 2000 and 2014. FVC… More >