Miguel Ángel Gómez-Luque^*, Guillermo Lendínez-Cano, Carmen Belén Congregado-Ruiz, Ignacio Osman-García, Rafael Antonio Medina-López

Canadian Journal of Urology, Vol.32, No.2, pp. 101-109, 2025, DOI:10.32604/cju.2025.063073 - 30 April 2025

Abstract Introduction: In recent years, significant advancements in the treatment of metastatic renal cell carcinoma (mRCC) have notably extended overall survival (OS) times, particularly with the introduction of tyrosine kinase inhibitors (TKIs) and combination immunotherapy. However, survival outcomes in mRCC remain highly variable. Materials and Methods: This study retrospectively analyzed clinical and demographic factors at diagnosis in patients treated for mRCC to identify predictors of long-term survival (defined as OS ≥ 48 months). Patients were categorized into long-term survivors (LTS) and non-long-term survivors (nLTS). Results: The analysis revealed that factors such as better Karnofsky Performance Status (KPS), More >

Sipawath Khamplod^1,2, Yodying Kaolawanich^1,2, Khemajira Karaketklang³, Nithima Ratanasit^1,2,*

Congenital Heart Disease, Vol.19, No.1, pp. 93-105, 2024, DOI:10.32604/chd.2024.048631 - 20 March 2024

Abstract Background: Atrial septal defect (ASD) is a common form of adult congenital heart disease that can lead to long-term adverse outcomes if left untreated. Early closure of ASD has been associated with excellent outcomes and lower complication rates. However, there is limited evidence regarding the prognosis of ASD closure in older adults. This study aims to evaluate the mortality rates in older ASD patients with and without closure. Methods: A retrospective cohort study was conducted on patients aged 40 years or older with ASD between 2001 and 2017. Patients were followed up to assess all-cause… More > Graphic Abstract

Frederick P. Mendiola, Kevin C. Zorn, Ofer N. Gofrit, Albert A. Mikhail, Marcelo A. Orvieto, Lambda P. Msezane, Gary D. Steinberg

Canadian Journal of Urology, Vol.14, No.4, pp. 3628-3634, 2007

Abstract Introduction: Radical cystectomy (RC) with urinary diversion remains as one of the more complex urological procedures despite considerable progress in surgical technique. Increasing patient age, along with associated age-related comorbidities, may portend a poor outcome in those undergoing such complicated surgical procedures. Herein, we report our experience with radical cystectomy in the elderly population.
Methods: We retrospectively reviewed our RC results from 1995 to 2003. Patients ≥80 years old were included in this analysis. Perioperative outcomes, as well as overall and disease-free survival were evaluated.
Results: A total of 517 patients underwent RC with urinary diversion during… More >