QIN LIU^1,#, CHUNYAN NIU^2,#,*, QIANG ZHANG³, SHIQIN SUN⁴, YUE CHEN², YONGQIANG SHI²

BIOCELL, Vol.48, No.5, pp. 759-769, 2024, DOI:10.32604/biocell.2024.048551 - 06 May 2024

Abstract Background: Nonalcoholic fatty liver disease (NAFLD) is a global health concern with the acid sphingomyelinase (ASM)/ceramide (CE) pathway and the NOD-like receptor family, pyrin domain-containing protein 3 (NLRP3) inflammasome identified as pivotal players in lipid disorders and inflammation. This study explores the interaction mechanism between the ASM/CE pathway and NLRP3 in NAFLD cell models, aiming to understand the impact of amitriptyline (Ami), an ASM inhibitor, on lipid deposition and hepatocyte injury by regulating the ASM/CE-NLRP3 pathway. Methods: HepG2 and HL-7702 cells were exposed to free fatty acids (FFAs) to establish the NAFLD model. The cells… More >

Srilekha Muthukaruppankaruppiah^1,*, Shanker Rajendiran Nagalingam², Priya Murugasen³, Rajesh Nandaamarnath⁴

Intelligent Automation & Soft Computing, Vol.35, No.2, pp. 2309-2323, 2023, DOI:10.32604/iasc.2023.029598 - 19 July 2022

Abstract Malfunction of human liver happens due to non-alcoholic fatty liver. Fatty liver measurement is used for grading hepatic steatosis, fibrosis and cirrhosis. The various imaging techniques for measuring fatty liver are Magnetic Resonance Imaging, Ultrasound and Computed Tomography. Imaging modalities lead to the exposure of harmful radiation of electromagnetic waves because of frequent measurement. The continuous monitoring of fatty liver is never achieved through imaging techniques. In this paper, the human fatty liver measured through a Fatty Liver Sensor (FLS). The continuous monitoring of the fatty liver is achieved through the FLS. FLS is fabricated… More >

Mounita Ghosh¹, Md. Mohsin Sarker Raihan¹, M. Raihan², Laboni Akter¹, Anupam Kumar Bairagi³, Sultan S. Alshamrani⁴, Mehedi Masud^5,*

Intelligent Automation & Soft Computing, Vol.30, No.3, pp. 917-928, 2021, DOI:10.32604/iasc.2021.017989 - 20 August 2021

Abstract The liver is considered an essential organ in the human body. Liver disorders have risen globally at an unprecedented pace due to unhealthy lifestyles and excessive alcohol consumption. Chronic liver disease is one of the principal causes of death affecting large portions of the global population. An accumulation of liver-damaging factors deteriorates this condition. Obesity, an undiagnosed hepatitis infection, alcohol abuse, coughing or vomiting blood, kidney or hepatic failure, jaundice, liver encephalopathy, and many more disorders are responsible for it. Thus, immediate intervention is needed to diagnose the ailment before it is too late. Therefore,… More >

Pushpendra Kumar^1,2,*, Ramjeevan Singh Thakur³

CMC-Computers, Materials & Continua, Vol.68, No.3, pp. 3513-3529, 2021, DOI:10.32604/cmc.2021.016957 - 06 May 2021

Abstract The aim of this research is to develop a mechanism to help medical practitioners predict and diagnose liver disease. Several systems have been proposed to help medical experts by diminishing error and increasing accuracy in diagnosing and predicting diseases. Among many existing methods, a few have considered the class imbalance issues of liver disorder datasets. As all the samples of liver disorder datasets are not useful, they do not contribute to learning about classifiers. A few samples might be redundant, which can increase the computational cost and affect the performance of the classifier. In this… More >

Yuguo YI, Jiamin ZHENG, Yang ZHOU, Zhiqin LIU, Dan WENG^*

BIOCELL, Vol.44, No.1, pp. 7-11, 2020, DOI:10.32604/biocell.2020.08686 - 01 March 2020

Abstract Nonalcoholic fatty liver disease (NAFLD) represents a huge threat to public health of the whole world. Around 25% of NAFLD patients will progress to nonalcoholic steatohepatitis (NASH), which has been predicted to be the main reason for liver transplantation in the United States in 2020. Extensive effort has been devoted to investigating the underlying molecular mechanisms of NASH pathogenesis and developing new promising treatments. Recent studies have demonstrated that pyroptosis, an inflammatory programmed cell death mediated by inflammasome and gasdermin-D (GSDMD), is involved in the development and progression of NASH. This review aims to summarize More >

Jose A. Silva‐Sepulveda¹, Yudy Fonseca², Irine Vodkin³, Gabrielle Vaughn¹, Robert Newbury⁴, Vera Vavinskaya⁵, Jerry Dwek⁶, James C. Perry¹, Preeti Reshamwala⁷, Cynthia Baehling⁸, James Lyon⁹, Christopher Davis¹, Jesse W. Lee¹, Hannah El‐Sabrout¹⁰, Doaa Shahbah¹¹, Laith Alshawabkeh¹², John W Moore¹, Howaida El‐Said¹

Congenital Heart Disease, Vol.14, No.4, pp. 600-608, 2019, DOI:10.1111/chd.12770

Abstract Introduction: Liver fibrosis and cirrhosis are late complications in Fontan palliation. Liver biopsy is the gold standard. The goal of this study is to correlate transjugular liver biopsy (TJLB) in the setting of Fontan palliation with noninvasive testing and hemodynamics.
Methods: Between August 2014 and July 2017, 49 Fontan patients underwent TJLB. All the patients had hemodynamic evaluation, 28 patients had MRE (magnetic reso‐ nance elastography) and 40 patients had cardiopulmonary exercise test. Histologic liver fibrosis was quantitated using traditional histologic scoring systems and a modi‐ fied Ishak congestive hepatic fibrosis score.
Results: Median age 17.8 years, median… More >

Alexander Lemmer¹, Lisa VanWagner^1,2, Zaira Gasanova³, Steve Helmke^4,5, Gregory T. Everson^4,5, Daniel Ganger¹

Congenital Heart Disease, Vol.14, No.6, pp. 978-986, 2019, DOI:10.1111/chd.12831

Abstract Background & Aims: Fontan surgery for single ventricle congenital heart disease leads to Fontan‐associated liver disease (FALD). Typical laboratory tests, imaging, and histopathology cannot predict clinical severity in FALD. HepQuant SHUNT is a proprietary serum test of hepatic function and physiology that has not yet been evaluated in FALD.
Methods: Fourteen adult FALD patients at a single urban tertiary care center who underwent a Fontan procedure in childhood received HepQuant SHUNT testing between September 2015 and April 2018. The HepQuant SHUNT disease severity index (DSI) assesses global liver function and physiology from systemic and portal hepatic filtration… More >

Jessica L. Schachter¹, Manisha Patel², Samuel R. Horton³, A. Mike Devane⁴, Alex Ewing⁵, Gary A. Abrams⁶

Congenital Heart Disease, Vol.13, No.5, pp. 764-770, 2018, DOI:10.1111/chd.12650

Abstract Objective: As the population of patients with Fontan circulation surviving into adult‐ hood increases, hepatic cirrhosis has grown to be a significant cause of morbidity and mortality. Early detection of advanced hepatic fibrosis is imperative for proper inter‐ vention and consideration for heart or combined heart/liver transplantation. Noninvasive biomarkers and elastography have been evaluated for their diagnostic utility with variable results in the Fontan population.
Design: The cohort included 14 patients age 26.4 SD 7.5 who underwent Fontan surgery. All patients were evaluated with FibroSURE, shear wave elastography (SWE), hepatic duplex sonography, and liver biopsy. Liver fibrosis… More >

Michael V. Di Maria¹, Lindsey Silverman², Adel K. Younoszai¹, Mariana L. Meyers³, Kelley E. Capocelli⁴, Michael R. Narkewicz⁵

Congenital Heart Disease, Vol.13, No.3, pp. 444-449, 2018, DOI:10.1111/chd.12594

Abstract Background: The current management paradigm for children with single ventricle heart disease involves a series of palliative surgeries, culminating in the Fontan operation. This physiology results in a high central venous pressure, and in the setting of single ventricle heart disease, results in hepatic injury and fibrosis over time. Fontan-associated liver disease (FALD) is universally present in this cohort, and the current gold standard for diagnosis remains biopsy. Noninvasive assessments of liver fibrosis, such as ultrasound with elastography or acoustic radiation force impulse (ARFI), has been utilized in this cohort. The effect of poor cardiovascular efficiency,… More >