Mengyi Huang, Xin Gong
Oncology Research, Vol.26, No.7, pp. 1103-1111, 2018, DOI:10.3727/096504018X15164123839400
Abstract As a member of the miRNA family, let-7c has been identified as a tumor suppressor in many cancers. However,
the molecular biological function of let-7c in glioma has not been elucidated. The aim of this study was to
explore let-7c expression levels and evaluate its function in glioma cells. We first measured the expression
of let-7c in four glioma cell lines and a normal cell line by quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR), and the results showed that let-7c was downregulated in glioma cells. By
applying gain-of-function and loss-of-function assays, the experiments suggested More >
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