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  • Open Access

    ARTICLE

    Investigating Load Regulation Characteristics of a Wind-PV-Coal Storage Multi-Power Generation System

    Zhongping Liu1, Enhui Sun2,*, Jiahao Shi2, Lei Zhang2, Qi Wang1, Jiali Dong1

    Energy Engineering, Vol.121, No.4, pp. 913-932, 2024, DOI:10.32604/ee.2023.043973

    Abstract There is a growing need to explore the potential of coal-fired power plants (CFPPs) to enhance the utilization rate of wind power (wind) and photovoltaic power (PV) in the green energy field. This study developed a load regulation model for a multi-power generation system comprising wind, PV, and coal energy storage using real-world data. The power supply process was divided into eight fundamental load regulation scenarios, elucidating the influence of each scenario on load regulation. Within the framework of the multi-power generation system with the wind (50 MW) and PV (50 MW) alongside a CFPP (330 MW), a lithium-iron phosphate… More > Graphic Abstract

    Investigating Load Regulation Characteristics of a Wind-PV-Coal Storage Multi-Power Generation System

  • Open Access

    REVIEW

    Clinical implications of single cell sequencing for bladder cancer

    REZA YADOLLAHVANDMIANDOAB1,#, MEHRSA JALALIZADEH1,#, FRANCIELE APARECIDA VECHIA DIONATO1, KEINI BUOSI1, PATRÍCIA A. F. LEME1, LUCIANA S. B. DAL COL1, CRISTIANE F. GIACOMELLI1, ALEX DIAS ASSIS1, NASIM BASHIRICHELKASARI1, LEONARDO OLIVEIRA REIS1,2,*

    Oncology Research, Vol.32, No.4, pp. 597-605, 2024, DOI:10.32604/or.2024.045442

    Abstract Bladder cancer (BC) is the 10th most common cancer worldwide, with about 0.5 million reported new cases and about 0.2 million deaths per year. In this scoping review, we summarize the current evidence regarding the clinical implications of single-cell sequencing for bladder cancer based on PRISMA guidelines. We searched PubMed, CENTRAL, Embase, and supplemented with manual searches through the Scopus, and Web of Science for published studies until February 2023. We included original studies that used at least one single-cell technology to study bladder cancer. Forty-one publications were included in the review. Twenty-nine studies showed that this technology can identify… More > Graphic Abstract

    Clinical implications of single cell sequencing for bladder cancer

  • Open Access

    REVIEW

    LncRNAs unraveling their sponge role in glioblastoma and potential therapeutic applications

    CAIJUAN LIU, XINGHAO LI, YUXUAN WU, JINHUI YANG, MENGHAN WANG, YUNQI MA*

    BIOCELL, Vol.48, No.3, pp. 387-401, 2024, DOI:10.32604/biocell.2024.048791

    Abstract Glioblastoma multiforme (GBM), the most common and aggressive primary brain tumor in adults, is the most malignant and still has no cure. However, the novel role of long non-coding RNAs (lncRNAs) in the pathogenesis of glioblastoma is attracting extensive attention. LncRNAs are transcribed RNA molecules over 200 nucleotides long that do not encode proteins. Unlike small non-coding RNAs, such as microRNAs (miRNAs), lncRNAs have more complex secondary and tertiary structures that enable them to interact with DNA, RNA, and proteins and perform multiple regulatory functions. LncRNAs act as molecular sponges, absorbing and sequestering other biomolecules, particularly miRNAs, thereby preventing these… More > Graphic Abstract

    LncRNAs unraveling their sponge role in glioblastoma and potential therapeutic applications

  • Open Access

    REVIEW

    How aging affects bone health via the intestinal micro-environment

    HUAN HU1,2,*, YUE HUANG1, FANGZHOU LIU1, QIAN WANG1,2, YANZI YAO3,*

    BIOCELL, Vol.48, No.3, pp. 353-362, 2024, DOI:10.32604/biocell.2024.048311

    Abstract Increasing life expectancy and an aging population lead to age-related bone diseases like osteoporosis and low bone mass more prevalent. These conditions represent a common, costly and chronic burden, not only for elderly but also to society at large. Consequently, elucidating the pathophysiology and developing effective therapies for these diseases is of paramount importance. Recent advances in research have identified the gut as a novel and promising target for addressing bone disorders, giving rise to the concept of the “gut-bone axis”. An in-depth review of the latest insights into the effects of age-related physiological changes in the gastrointestinal tract on… More >

  • Open Access

    ARTICLE

    Security Monitoring and Management for the Network Services in the Orchestration of SDN-NFV Environment Using Machine Learning Techniques

    Nasser Alshammari1, Shumaila Shahzadi2, Saad Awadh Alanazi1,*, Shahid Naseem3, Muhammad Anwar3, Madallah Alruwaili4, Muhammad Rizwan Abid5, Omar Alruwaili4, Ahmed Alsayat1, Fahad Ahmad6,7

    Computer Systems Science and Engineering, Vol.48, No.2, pp. 363-394, 2024, DOI:10.32604/csse.2023.040721

    Abstract Software Defined Network (SDN) and Network Function Virtualization (NFV) technology promote several benefits to network operators, including reduced maintenance costs, increased network operational performance, simplified network lifecycle, and policies management. Network vulnerabilities try to modify services provided by Network Function Virtualization MANagement and Orchestration (NFV MANO), and malicious attacks in different scenarios disrupt the NFV Orchestrator (NFVO) and Virtualized Infrastructure Manager (VIM) lifecycle management related to network services or individual Virtualized Network Function (VNF). This paper proposes an anomaly detection mechanism that monitors threats in NFV MANO and manages promptly and adaptively to implement and handle security functions in order… More >

  • Open Access

    ARTICLE

    Optimizing Household Wastes (Rice, Vegetables, and Fruit) as an Environmentally Friendly Electricity Generator

    Deni Ainur Rokhim1,2, Isma Yanti Vitarisma1, Sumari Sumari1,*, Yudhi Utomo1, Muhammad Roy Asrori1

    Journal of Renewable Materials, Vol.12, No.2, pp. 275-284, 2024, DOI:10.32604/jrm.2023.043419

    Abstract The high consumption of electricity and issues related to fossil energy have triggered an increase in energy prices and the scarcity of fossil resources. Consequently, many researchers are seeking alternative energy sources. One potential technology, the Microbial Fuel Cell (MFC) based on rice, vegetable, and fruit wastes, can convert chemical energy into electrical energy. This study aims to determine the potency of rice, vegetable, and fruit waste assisted by Cu/Mg electrodes as a generator of electricity. The method used was a laboratory experiment, including the following steps: electrode preparation, waste sample preparation, incubation of the waste samples, construction of a… More >

  • Open Access

    ARTICLE

    Preparation of Environmentally Friendly Urea-Hexanediamine-Glyoxal (HUG) Resin Wood Adhesive

    Qianyu Zhang1,2,#, Shi Chen1,2,#, Long Cao1,2, Hong Lei3, Antonio Pizzi4, Xuedong Xi1,2,*, Guanben Du1,2

    Journal of Renewable Materials, Vol.12, No.2, pp. 235-244, 2024, DOI:10.32604/jrm.2023.029537

    Abstract Using non-toxic, low-volatile glyoxal to completely replace formaldehyde for preparing urea-glyoxal (UG) resin adhesive is a hot research topic that could be of great interest for the wood industry. However, urea-glyoxal (UG) resins prepared by just using glyoxal instead of formaldehyde usually yields a lower degree of polymerization. This results in a poorer bonding performance and water resistance of UG resins. A good solution is to pre-react urea to preform polyurea molecules presenting already a certain degree of polymerization, and then to condense these with glyoxal to obtain a novel UG resin. Therefore, in this present work, the urea was… More > Graphic Abstract

    Preparation of Environmentally Friendly Urea-Hexanediamine-Glyoxal (HUG) Resin Wood Adhesive

  • Open Access

    ARTICLE

    Differential Expression of Genes Related to Fruit Development and Capsaicinoids Synthesis in Habanero Pepper Plants Grown in Contrasting Soil Types

    Eduardo Burgos-Valencia1,#, Federico García-Laynes1,#, Ileana Echevarría-Machado1, Fatima Medina-Lara1, Miriam Monforte-González1, José Narváez-Zapata2,*, Manuel Martínez-Estévez1,*

    Phyton-International Journal of Experimental Botany, Vol.93, No.2, pp. 151-183, 2024, DOI:10.32604/phyton.2023.046943

    Abstract Habanero pepper (Capsicum chinense Jacq.) is a crop of economic relevance in the Peninsula of Yucatan. Its fruits have a high level of capsaicinoids compared to peppers grown in other regions of the world, which gives them industrial importance. Soil is an important factor that affects pepper development, nutritional quality, and capsaicinoid content. However, the effect of soil type on fruit development and capsaicinoid metabolism has been little understood. This work aimed to compare the effect of soils with contrasting characteristics, black soil (BS) and red soil (RS), on the expression of genes related to the development of fruits, and… More >

  • Open Access

    ARTICLE

    A novel oxaliplatin-resistant gene signatures predicting survival of patients in colorectal cancer

    QIOU GU1, CHUILIN LAI1, XIAO GUAN1, JING ZHU2, TIAN ZHAN1, JIANPING ZHANG1,*

    BIOCELL, Vol.48, No.2, pp. 253-269, 2024, DOI:10.32604/biocell.2023.028336

    Abstract Objectives: Colorectal cancer (CRC) is a serious threat to human health worldwide. Oxaliplatin is a platinum analog and is widely used to treat CRC. However, resistance to oxaliplatin restricts its effectiveness and application while its target recognition and mechanism of action also remain unclear. Therefore, we aimed to develop an oxaliplatin-resistant prognostic model to clarify these aspects. Methods: We first obtained oxaliplatin-resistant and parental cell lines, and identified oxaliplatin-resistant genes using RNA sequencing (RNA-seq) and differential gene analysis. We then acquired relevant data from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. Cox regression and Least Absolute… More > Graphic Abstract

    A novel oxaliplatin-resistant gene signatures predicting survival of patients in colorectal cancer

  • Open Access

    ARTICLE

    Glycogen metabolism-mediated intercellular communication in the tumor microenvironment influences liver cancer prognosis

    YANG ZHANG1,2,#, NANNAN QIN5,#, XIJUN WANG6,#, RUI LIANG7, QUAN LIU4, RUOYI GENG8, TIANXIAO JIANG8, YUNFEI LIU8,*, JINWEI LI3,4,*

    Oncology Research, Vol.32, No.3, pp. 563-576, 2024, DOI:10.32604/or.2023.029697

    Abstract Glycogen metabolism plays a key role in the development of hepatocellular carcinoma (HCC), but the function of glycogen metabolism genes in the tumor microenvironment (TME) is still to be elucidated. Single-cell RNA-seq data were obtained from ten HCC tumor samples totaling 64,545 cells, and 65 glycogen metabolism genes were analyzed by a nonnegative matrix factorization (NMF). The prognosis and immune response of new glycogen TME cell clusters were predicted by using HCC and immunotherapy cohorts from public databases. HCC single-cell analysis was divided into fibroblasts, NT T cells, macrophages, endothelial cells, and B cells, which were separately divided into new… More >

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