Ziying Huang¹, Ruikang Ma¹, Anning Li², Yufei Cheng¹, Xiaolin Lin², Mengzhi Li³, Yu Zhang², Liping Shi¹, Linlin Dong^1,*

Phyton-International Journal of Experimental Botany, Vol.95, No.1, 2026, DOI:10.32604/phyton.2025.074419 - 30 January 2026

Abstract Epimedium is commonly used to treat bone injury and kidney disease, with prenylated flavonol glycosides (PFGs) as its active ingredients. It has attracted much attention due to prominent healthcare and therapeutic effects, but faces problems of adulteration with closely related species and confusion about geographical origins. In this study, multiple technical approaches were employed to identify its genetic characteristics and metabolic differences. Based on DNA barcoding, 20 batches of samples were analyzed. The genetic distances of matK, ITS and psbA-trnH within species were all smaller than those between species, and psbA-trnH along with ITS + psbA-trnH proved most effective… More >

Dilfuza Jabborova^1,2,3,*, Khurshid Sulaymanov¹, Muzafar Jabborov⁴, Nayan Ahmed⁵, Tatiana Minkina⁶, Olga Biryukova⁶, Nasir Mehmood^6,*, Vishnu D. Rajput⁶

Phyton-International Journal of Experimental Botany, Vol.95, No.1, 2026, DOI:10.32604/phyton.2026.072577 - 30 January 2026

Abstract The combined effects of macronutrients (Nitrogen, Phosphorus, and Potassium-N, P, K) and micronutrient fertilization on turmeric yield, soil enzymatic activity, microbial biomass, and nutrient dynamics remains poorly understood, despite their significance for sustainable soil fertility management and optimizing crop productivity across diverse agroecosystems. To investigate, a net house experiment on sandy loam Haplic Chernozem was conducted to 03 fertilizer regimes, viz. N₇₅P₅₀K₅₀ kg ha⁻¹ (T-2), N₁₂₅P₁₀₀K₁₀₀ kg ha⁻¹ (T-3), and N₁₀₀P₇₅K₇₅ + B₃Zn₆Fe₆ kg ha⁻¹ (T-4). Furthermore, the influence of these treatments was systematically assessed on soil nutrient status (N, P, K), enzymatic activities (alkaline phosphomonoesterase, dehydrogenase, fluorescein diacetate… More >

Sana Shahab¹, Vladimir Simic^2,*, Ashit Kumar Dutta^3,4, Mohd Anjum^5,*, Dragan Pamucar^6,7,8

CMES-Computer Modeling in Engineering & Sciences, Vol.146, No.1, 2026, DOI:10.32604/cmes.2025.073945 - 29 January 2026

Abstract Environmental problems are intensifying due to the rapid growth of the population, industry, and urban infrastructure. This expansion has resulted in increased air and water pollution, intensified urban heat island effects, and greater runoff from parks and other green spaces. Addressing these challenges requires prioritizing green infrastructure and other sustainable urban development strategies. This study introduces a novel Integrated Decision Support System that combines Pythagorean Fuzzy Sets with the Advanced Alternative Ranking Order Method allowing for Two-Step Normalization (AAROM-TN), enhanced by a dual weighting strategy. The weighting approach integrates the Criteria Importance Through Intercriteria Correlation… More >

Miriam Di Matteo^*, Domiziana Vespasiano, Gianluigi Lo Basso, Costanza Vittoria Fiorini, Andrea Vallati

Energy Engineering, Vol.123, No.2, 2026, DOI:10.32604/ee.2025.064353 - 27 January 2026

Abstract Decarbonising the building sector, particularly residential heating, represents a critical challenge for achieving carbon-neutral energy systems. Efficient solutions must integrate both technological performance and renewable energy sources while considering operational constraints of existing systems. This study investigates a hybrid heating system combining a natural gas boiler (NGB) with an air-to-water heat pump (AWHP), evaluated through a combination of laboratory experiments and dynamic modelling. A prototype developed in the Electrical and Energy Engineering Laboratory enabled the characterization of both heat generators, the collection of experimental data, and the calibration of a MATLAB/Simulink model, including emissions and… More >

Yang Wu^1,#,*, Dong Xu^1,#, Run Shi¹, Mingwei Zhan², Shaohui Xu³, Xin Wang⁴, Jianpeng Zhang⁵, Zhaokai Zhou⁶, Weizhuo Wang⁷, Yongjie Wang⁸, Minglun Li⁹, Zihao Xu^10,*, Kaifeng Su^11,*

Oncology Research, Vol.34, No.2, 2026, DOI:10.32604/or.2025.073265 - 19 January 2026

Abstract Prostate cancer (PCa) remains a major cause of cancer-related mortality in men, largely due to therapy resistance and metastatic progression. Increasing evidence highlights the tumor microenvironment (TME), particularly cancer-associated fibroblasts (CAFs), as a critical determinant of disease behavior. CAFs constitute a heterogeneous population originating from fibroblasts, mesenchymal stem cells, endothelial cells, epithelial cells undergoing epithelial–mesenchymal transition (EMT), and adipose tissue. Through dynamic crosstalk with tumor, immune, endothelial, and adipocyte compartments, CAFs orchestrate oncogenic processes including tumor proliferation, invasion, immune evasion, extracellular matrix remodeling, angiogenesis, and metabolic reprogramming. This review comprehensively summarizes the cellular origins, phenotypic More >

Xinyang Li^1,2,3,#, Luyuan Ma^1,2,3,#, Chuan Shen^1,2,3, Ruolan Gu^1,2,3, Shilong Dong^1,2,3, Mingjie Liu^1,2,3, Ying Xiao^1,2,3, Wenpeng Liu^1,2,3, Yuexia Liu^1,2,3, Caiyan Zhao^1,2,3,*

Oncology Research, Vol.34, No.2, 2026, DOI:10.32604/or.2025.073179 - 19 January 2026

Abstract Background: Hepatocellular carcinoma (HCC) is an aggressive and lethal malignancy. Metabolic reprogramming dynamically remodels the tumor microenvironment (TME) and drives HCC progression. This study investigated the mechanism through which metabolic reprogramming remodels the TME in HCC. Methods: HCC patient transcriptome data were subjected to bioinformatics analysis to identify differentially expressed genes and immune infiltration status. Immunohistochemical analysis was performed to determine the correlation between succinate dehydrogenase complex subunit A (SDHA) expression and M2 macrophage infiltration. SDHA-knockdown or SDHA-overexpressing HCC cells were used for in vitro experiments, including co-culturing, flow cytometry, and enzyme-linked immunosorbent assay. Western blotting… More >

Bu Zou^1,#, Yi-En Xu^2,#, Hui-Chan He³, Zu-Lu Ye², Da-Lei Zhou², Cai-Yun He^2,*, Chan Huang^4,*

Oncology Research, Vol.34, No.2, 2026, DOI:10.32604/or.2025.069453 - 19 January 2026

Abstract Objectives: Gastric cancer (GC) remains a major global health concern, and Phosphoinositide-3-Kinase Regulatory Subunit 1 (PIK3R1), a regulatory subunit of the PI3K signaling pathway, may play a critical yet underexplored role in GC progression. This study aimed to investigate the prognostic significance of PIK3R1 in GC and its association with the tumor immune microenvironment. Methods: PIK3R1 expression and its clinical relevance were analyzed using datasets from GC patients who underwent gastrectomy, including cohorts from The Cancer Genome Atlas (TCGA) and the Sun Yat-sen University Cancer Center (SYSUCC). Prognostic models integrating PIK3R1 expression with clinical parameters… More >

Girish Hariharan¹, Vinyas¹, Gowrishankar Mandya Chennegowda¹, Nitesh Kumar¹, Shiva Kumar¹, Deepak Doreswamy², Subraya Krishna Bhat^1,*

CMC-Computers, Materials & Continua, Vol.86, No.3, 2026, DOI:10.32604/cmc.2025.073772 - 12 January 2026

Abstract This study presents a framework involving statistical modeling and machine learning to accurately predict and optimize the mechanical and damping properties of hybrid granite–epoxy (G–E) composites reinforced with cast iron (CI) filler particles. Hybrid G–E composite with added cast iron (CI) filler particles enhances stiffness, strength, and vibration damping, offering enhanced performance for vibration-sensitive engineering applications. Unlike conventional approaches, this work simultaneously employs Artificial Neural Networks (ANN) for high-accuracy property prediction and Response Surface Methodology (RSM) for in-depth analysis of factor interactions and optimization. A total of 24 experimental test data sets of varying input… More >

Lifu He¹, Zhongchu Huang¹, Haidong Shao^2,*, Zhangbo Hu¹, Yuting Wang¹, Jie Mei¹, Xiaofei Zhang³

CMC-Computers, Materials & Continua, Vol.86, No.3, 2026, DOI:10.32604/cmc.2025.073227 - 12 January 2026

Abstract Deep learning-based wind turbine blade fault diagnosis has been widely applied due to its advantages in end-to-end feature extraction. However, several challenges remain. First, signal noise collected during blade operation masks fault features, severely impairing the fault diagnosis performance of deep learning models. Second, current blade fault diagnosis often relies on single-sensor data, resulting in limited monitoring dimensions and ability to comprehensively capture complex fault states. To address these issues, a multi-sensor fusion-based wind turbine blade fault diagnosis method is proposed. Specifically, a CNN-Transformer Coupled Feature Learning Architecture is constructed to enhance the ability to More >

Sun Park^*, JongWon Kim

CMC-Computers, Materials & Continua, Vol.86, No.3, 2026, DOI:10.32604/cmc.2025.072865 - 12 January 2026

Abstract In real-world autonomous driving tests, unexpected events such as pedestrians or wild animals suddenly entering the driving path can occur. Conducting actual test drives under various weather conditions may also lead to dangerous situations. Furthermore, autonomous vehicles may operate abnormally in bad weather due to limitations of their sensors and GPS. Driving simulators, which replicate driving conditions nearly identical to those in the real world, can drastically reduce the time and cost required for market entry validation; consequently, they have become widely used. In this paper, we design a virtual driving test environment capable of More >