Hui Li^*1, Huicheng Chen^†1, Haibin Wang^‡, Yilong Dong^†, Min Yin^†, Liang Zhang^§, Jia Wei^*

Oncology Research, Vol.26, No.4, pp. 557-563, 2018, DOI:10.3727/096504017X15000784459799

Abstract Hepatocellular carcinoma (HCC) is a disease with poor prognosis rates and ineffective therapeutic options. Previous studies have reported the involvement of mitogen-inducible gene 6 (MIG-6) as a negative regulator in tumor formation. MicroRNAs (miRNAs) play crucial roles in the development of different types of cancer. However, the underlying mechanisms of miRNAs in HCC are poorly understood. This study was aimed to investigate the role of miR-374a in HCC and its role in the regulation of expression of MIG-6. The results showed that MIG-6 overexpression significantly inhibited cell viability of HepG2 cells after 4 days posttransfection. More >

Ping Zhang¹, Zhiyou Kong², Junna Liu¹, Yongjiang Liu¹, Qianchao Wang¹, Xiuju Huan¹, Li Li¹, Yunfeng Jiang³, Peng Qin^1,*

Phyton-International Journal of Experimental Botany, Vol.91, No.2, pp. 375-394, 2022, DOI:10.32604/phyton.2022.016358

Abstract Drought is the main abiotic stress that restricts wheat production. The rapid development of sequencing technology and its widespread application to various fields have revealed the structural characteristics and regulation of related genes through gene expression analysis. Here, we studied responses of wheat plants under drought and re-watering conditions, using morphological and physiological indicators. Moreover, a transcriptome analysis was conducted on Jingmai 12, a drought-resistant wheat strain, to explore the mechanism underlying the response of drought-resistant wheat seedlings to drought stress at the transcriptome level. Drought stress caused morphological and physiological changes in both drought-resistant… More >