Prathap Sarma¹, Palesa Mogane^2,*, Katharina Vanderdonck³, Moses Kebalepile¹, Palesa Motshabi Chakane⁴

Congenital Heart Disease, Vol.20, No.1, pp. 41-53, 2025, DOI:10.32604/chd.2025.060382 - 18 March 2025

Abstract Background: Congenital cardiac diseases (CCD) are common congenital birth defects that require high-risk surgery. Outcomes following congenital cardiac surgery in children living in high-income countries (HIC) have been documented, but little is known from the African continent. This study aimed to determine factors associated with perioperative mortality in patients who underwent congenital cardiac surgery at our institution. Methods: This retrospective, cross-sectional study was conducted at Charlotte Maxeke Johannesburg Academic Hospital over 12 years (2006–2017). A multivariable regression analysis was performed for the factors which had a p-value of 0.1 and less in the univariable regression analysis. A… More >

Mohamad Amin Pourhoseingholi^11,, Amirreza Raffei Javazm^1,, Naghmeh Asadimanesh², Fatemeh Shojaeian³, Mehdi Azizmohammad Looha¹, Seyed Amir Ahmad Safavi-Naini¹, Benyamin Mohammadzadeh^1,4, Parnian Jamshidi^1,4, Fatemeh Gholampoor², Omid Yazdani², Nadia Zameni², Zahra Azizan², Amirhossein Sahebkar^5,6

European Cytokine Network, Vol.34, No.2, pp. 10-19, 2023, DOI:10.1684/ecn.2023.0485

Abstract Background: Coronavirus infection can induce the production of inflammatory cytokines leading to acute respiratory distress syndrome (ARDS) and death. It is well-established that interferons (IFNs) are essential in regulating the immune response, thus their effects of IFNs on COVID-19 patients should be subject to investigation. This study aimed to investigate the effects of IFN-α alone or in combination with remdesivir in hospitalized COVID-19 patients. Material and Methods: A multicentre, retrospective study was conducted on COVID-19 patients admitted to three hospitals in Tehran, Iran, from March 20, 2020, to March 18, 2021. The unadjusted and adjusted effects of… More >

Laortip Rattanapittayaporn, Maliwan Oofuvong^*, Jutarat Tanasansuttiporn, Thavat Chanchayanon

Congenital Heart Disease, Vol.18, No.1, pp. 23-39, 2023, DOI:10.32604/chd.2023.026026 - 09 January 2023

Abstract Background: Prolonged preoperative fasting can cause hypoglycemia, hyperglycemia, and intravascular volume depletion in children. We aimed to examine whether prolonged preoperative fasting is associated with in-hospital mortality and other morbidities in pediatric cardiothoracic surgery. Methods: This retrospective cohort study included children aged 0–3 years who underwent cardiac surgery between July 2014 and October 2020. The patient demographic data, surgery-related and anesthesia-related factors, and postoperative outcomes, including hypoglycemia, hyperglycemia, sepsis, length of intensive care unit stay, and in-hospital mortality, were recorded. The main exposure and outcome variables were prolonged fasting and time-to-death after surgery, respectively. The associations between… More > Graphic Abstract