Dongchi Cai^1,2,#, Jialin Ji^3,#, Chunhui Yang^1,*, Hong Cai^1,*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.071152 - 30 December 2025

Abstract Metabolic reprogramming involving branched-chain amino acids (BCAAs)—leucine, isoleucine, and valine—is increasingly recognized as pivotal in cancer progression, metastasis, and immune modulation. This review comprehensively explores how cancer cells rewire BCAA metabolism to enhance proliferation, survival, and therapy resistance. Tumors manipulate BCAA uptake and catabolism via high expression of transporters like L-type amino acid transporter 1 (LAT1) and enzymes including branched chain amino acid transaminase 1(BCAT1), branched chain amino acid transaminase 2 (BCAT2), branched-chain alpha-keto acid dehydrogenase (BCKDH), and branched chain alpha-keto acid dehydrogenase kinase (BCKDK). These alterations sustain energy production, biosynthesis, redox homeostasis, and oncogenic… More >

Nikhil S. Mane¹, Sheetal Kumar Dewangan^2,*, Sayantan Mukherjee³, Pradnyavati Mane⁴, Deepak Kumar Singh¹, Ravindra Singh Saluja⁵

CMC-Computers, Materials & Continua, Vol.86, No.1, pp. 1-16, 2026, DOI:10.32604/cmc.2025.072090 - 10 November 2025

Abstract The thermal conductivity of nanofluids is an important property that influences the heat transfer capabilities of nanofluids. Researchers rely on experimental investigations to explore nanofluid properties, as it is a necessary step before their practical application. As these investigations are time and resource-consuming undertakings, an effective prediction model can significantly improve the efficiency of research operations. In this work, an Artificial Neural Network (ANN) model is developed to predict the thermal conductivity of metal oxide water-based nanofluid. For this, a comprehensive set of 691 data points was collected from the literature. This dataset is split More >

Misbah Anwer^1,*, Ghufran Ahmed¹, Maha Abdelhaq², Raed Alsaqour³, Shahid Hussain⁴, Adnan Akhunzada^5,*

CMC-Computers, Materials & Continua, Vol.86, No.1, pp. 1-15, 2026, DOI:10.32604/cmc.2025.068673 - 10 November 2025

Abstract The exponential growth of the Internet of Things (IoT) has introduced significant security challenges, with zero-day attacks emerging as one of the most critical and challenging threats. Traditional Machine Learning (ML) and Deep Learning (DL) techniques have demonstrated promising early detection capabilities. However, their effectiveness is limited when handling the vast volumes of IoT-generated data due to scalability constraints, high computational costs, and the costly time-intensive process of data labeling. To address these challenges, this study proposes a Federated Learning (FL) framework that leverages collaborative and hybrid supervised learning to enhance cyber threat detection in… More >

Wufan Jia¹, Seung Hee Yoo², Hye Eun Lee^3,*

International Journal of Mental Health Promotion, Vol.27, No.12, pp. 1897-1906, 2025, DOI:10.32604/ijmhp.2025.071572 - 31 December 2025

Abstract Background: With growing concerns about the abuse of prescription and over-the-counter (OTC) medications, such as medications for attention-deficit/hyperactivity disorder (ADHD), diet pills, and sleep aids, among adolescents in South Korea, this study aimed to investigated how these substances affect key aspects of adolescent well-being, specifically school satisfaction, body image, and sleep quality, and their association with mental health outcomes. Methods: A two-wave longitudinal survey was conducted with Korean female high school students (Wave 1: n = 494; Wave 2: n = 189). Linear regression analyses were used to evaluate the effects of ADHD medications, diet pills, and… More >

Oleh Koshovyi¹, Amal D. Premarathna², Rando Tuvikene², Valdas Jakštas^3,4, Vaidotas Žvikas³, Yurii Hrytsyk⁵, Lyubov Grytsyk⁵, Andriy Grytsyk⁵, Jaan Liira⁶, Ain Raal^1,*

Phyton-International Journal of Experimental Botany, Vol.94, No.12, pp. 3991-4019, 2025, DOI:10.32604/phyton.2025.074153 - 29 December 2025

Abstract Gilia capitata Sims (Polemoniaceae) is an annual herbaceous plant widely distributed in western North America and cultivated as an ornamental flower. The detailed chemical composition and pharmacological properties of this plant have not been previously reported. This study aimed to investigate the chemical composition and pharmacological activity of aqueous-ethanolic extracts derived from different plant parts (herb, flowers, stems, roots, and fruits). HPLC analysis identified 12 phenolic compounds and 16 amino acids in the aqueous-ethanolic extracts obtained from these plant parts. The biological effects of the extracts were evaluated in vitro, including cytotoxicity, anti-inflammatory response, and wound-healing potential.… More >

Mustansar Mubeen¹, Yasir Iftikhar^1,*, Ganesan Vadamalai^2,3, Muhammad Aasim⁴, Muhammad Faiq⁵, Uthman Balgith Algopishi⁶, Ahmed Ezzat Ahmed^6,7

Phyton-International Journal of Experimental Botany, Vol.94, No.12, pp. 3827-3843, 2025, DOI:10.32604/phyton.2025.071555 - 29 December 2025

Abstract Citrus viroids are small non-coding RNA pathogens that pose a significant threat to global citrus production by reducing fruit yield, quality, and tree longevity. Several viroids, including Citrus exocortis viroid (CEVd), Hop stunt viroid (HSVd), Citrus bent leaf viroid (CBLVd), and newly identified members such as Citrus Viroid VI (CVd-VI) and Citrus Viroid VII (CVd-VII) have been reported from diverse citrus-growing regions. These pathogens are transmitted mainly through vegetative propagation, contaminated tools, and occasionally via seed or pollen, making their management complex. This review synthesizes current knowledge on the biology, structural diversity, transmission, symptomatology, detection,… More >

Luke Patrick O’Connor¹, Alexander Jordan Henry², Wendy Michelle Novicoff³, Marwan Ali², Adam Seth Baumgarten⁴, Nicolas Martin Ortiz^2,*

Canadian Journal of Urology, Vol.32, No.6, pp. 621-626, 2025, DOI:10.32604/cju.2025.065217 - 30 December 2025

Abstract Background: Postoperative pain management after penile prosthesis (PP) has traditionally required opioid medication. Recently, urologic prosthetic surgeons have sought to establish opioid-free protocols (OFP) and/or opioid-reduced protocols (ORP) for PP postoperative pain management. We sought to investigate the adoption patterns of OFP/ORP among surgeons who perform PP surgery and identify barriers to implementation. Methods: A 13-question confidential survey was sent to members of the Sexual Medicine Society of North America (SMSNA) and the Society of Urologic Prosthetic Surgeons (SUPS) via email. The survey was administered via Qualtrics. A t-test was used to analyze survey responses. Results:… More >

Wenjun Hu, Liquan Zhang^*

Journal of Polymer Materials, Vol.42, No.4, pp. 1159-1179, 2025, DOI:10.32604/jpm.2025.072450 - 26 December 2025

Abstract Addressing the persistent challenge of shale hydration and swelling in water-based drilling fluids (WBDFs), this study developed a smart thermo-responsive shale inhibitor, Hyperbranched Polyethyleneimine-Propylene Oxide-N-isopropylacrylamide (HPN). It was synthesized by grafting hyperbranched polyethyleneimine (HPEI) with propylene oxide (PO) and N-isopropylacrylamide (NIPAM), creating a synergistic hydration barrier through hydrophobic association and temperature-triggered pore plugging. Structural characterization by Fourier-Transform Infrared (FTIR) spectroscopy and gel permeation chromatography (GPC) confirmed the successful formation of the HPN terpolymer, revealing a unique “cationic–nonionic” amphiphilic architecture with temperature-responsive properties. Performance evaluation demonstrated that HPN significantly outperforms conventional inhibitors, including potassium chloride (KCl),… More >

Asgar Ali^1,*, Nayan Sardar², Poly Karmakar³, Sanatan Das⁴

CMES-Computer Modeling in Engineering & Sciences, Vol.145, No.3, pp. 3563-3626, 2025, DOI:10.32604/cmes.2025.074082 - 23 December 2025

Abstract Hybrid nanofluids have gained significant attention for their superior thermal and rheological characteristics, offering immense potential in energy conversion, biomedical transport, and electromagnetic flow control systems. Understanding their dynamic behavior under coupled magnetic, rotational, and reactive effects is crucial for the development of efficient thermal management technologies. This study develops a neuro-fuzzy computational framework to examine the dynamics of a reactive Cu–TiO₂–H₂O hybrid nanofluid flowing through a squarely elevated Riga tunnel. The governing model incorporates Hall and ion-slip effects, thermal radiation, and first-order chemical reactions under ramped thermo-solutal boundary conditions and rotational electromagnetic forces. Closed-form analytical… More >

Arshad Riaz^1,*, Misbah Ilyas¹, Muhammad Naeem Aslam², Safia Akram³, Sami Ullah Khan⁴, Ghaliah Alhamzi⁵

CMES-Computer Modeling in Engineering & Sciences, Vol.145, No.3, pp. 3481-3509, 2025, DOI:10.32604/cmes.2025.072513 - 23 December 2025

Abstract Peristaltic transport of non-Newtonian nanofluids with double diffusion is essential to biological engineering, microfluidics, and manufacturing processes. The authors tackle the key problem of Sisko nanofluids under double diffusion convection with thermal radiations and electroosmotic effects. The study proposes a solution approach by using Morlet-Wavelet Neural Networks that can effectively solve this complex problem by their superior ability in the capture of nonlinear dynamics. These convergence analyses were calculated across fifty independent runs. Theil’s Inequality Coefficient and the Mean Squared Error values range from 10⁻⁷ to 10⁻⁵ and 10⁻⁷ to 10⁻¹⁰, respectively. These values showed the proposed More >