Sarra B. Shakartalla1,2,3, Iman M. Talaat1,2,4,*, Nival Ali1, Shahenaz S. Salih1,5, Zainab M. Al Shareef1,2, Noura Alkhayyal6, Riyad Bendardaf2,7,*, Sameh S. M. Soliman1,8,*
Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.070808
- 30 December 2025
Abstract Objectives: Breast cancer (BC) is the leading cause of cancer-related mortality in women, largely due to metastasis. This study aims to explore the role of purine nucleoside phosphorylase (PNP), a key enzyme in purine metabolism, in the aggressiveness and metastatic behavior of BC. Methods: A comprehensive analysis was performed using in silico transcriptomic data (n = 2509 patients), immunohistochemical profiling of BC tissues (n = 103), and validation through western blotting in multiple BC cell lines. Gene expression and survival analyses were conducted using Tumor Immune Estimation Resource (TIMER), Gene Expression Profiling Interactive Analysis 2 (GEPIA2), and… More >
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