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  • Open Access

    ABSTRACT

    Comparisons of Patient-specific Active and Passive Models for Left Ventricle in Hypertrophic Obstructive Cardiomyopathy

    Xueying Huang1,*, Long Deng2, Chun Yang3, Mary Lesperance4, Dalin Tang5

    Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 58-58, 2019, DOI:10.32604/mcb.2019.06969

    Abstract Hypertrophic cardiomyopathy (HCM) occurs in about 1 of every 500 adults in the general population. It has been reported that left ventricular outflow tract obstruction (LVOTO) is observed in 70% patients with HCM. Systolic anterior motion (SAM) of the mitral valve (MV) is the dominant cause of dynamic outflow tract obstruction in most patients with hypertrophic obstructive cardiomyopathy (HOCM). Currently, the hemodynamic mechanisms of SAM remain unclear. In this study, we developed 12 active and corresponding passive models based on 6 patients’ pre- and post-operative ECG-gated cardiac CT images of patients’ LV at the pre-SAM… More >

  • Open Access

    ARTICLE

    Angle of Attack Between Blood Flow and Mitral Valve Leaflets in Hypertrophic Obstructive Cardiomyopathy: An In Vivo Multi-patient CT-based FSI Study

    Long Deng1, Xueying Huang2,3,*, Heng Zuo4, Yuan Zheng2, Chun Yang5, Yunhu Song1, Dalin Tang6

    CMES-Computer Modeling in Engineering & Sciences, Vol.116, No.2, pp. 115-125, 2018, DOI:10.31614/cmes.2018.04076

    Abstract The mechanisms of systolic anterior motion (SAM) of the mitral valve in hypertrophic obstructive cardiomyopathy (HOCM) remain unclear. To investigate the angle of attack between blood flow and mitral valve leaflets at pre-SAM time point, patient-specific CT-based computational models were constructed for 5 patients receiving septal myectomy surgery to obtain pre- and post-operative 2D vector flow mapping. The comparisons between pre- and post-operative angles of attack based on 2D vector flow mapping of 5 patients were performed. It was found that there was no statistically significant difference between pre- and post-operative angles of attack (61.1±t More >

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