Vladimir Ya. Modorskii, Ivan E. Cherepanov^*

FDMP-Fluid Dynamics & Materials Processing, Vol.20, No.5, pp. 1031-1043, 2024, DOI:10.32604/fdmp.2024.048494

Abstract A transition to clean hydrogen energy will not be possible until the issues related to its production, transportation, storage, etc., are adequately resolved. Currently, however, it is possible to use methane-hydrogen mixtures. Natural gas can be transported using a pipeline system with the required pressure being maintained by gas compression stations. This method, however, is affected by some problems too. Compressors emergency stops can be induced by vibrations because in some cases, mechanical methods are not able to reduce the vibration amplitude. As an example, it is known that a gas-dynamic flow effect in labyrinth… More >

Yueli Gu^*, Jinchun Si^†, Xichun Xiao^*, Ying Tian^*, Shuo Yang^*

Oncology Research, Vol.25, No.7, pp. 1069-1079, 2017, DOI:10.3727/096504016X14829256525028

Abstract Aberrant expression of microRNA-92a (miR-92a) has been investigated in various cancers. However, the function and mechanism of miR-92a in acute myeloid leukemia (AML) remain to be elucidated. Our data showed that miR-92a was evidently downregulated and methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) was remarkably upregulated in AML cell lines HL-60 and THP-1. Dual luciferase reporter assay revealed that MTHFD2 was a direct target of miR-92a. Gain- and loss-of-function analysis demonstrated that MTHFD2 knockdown or miR-92a overexpression notably inhibited proliferation and promoted apoptosis of AML cell lines. Restoration of MTHFD2 expression reversed proliferation inhibition and apoptosis induction of More >

Wei Lei¹, Wang Kang¹, Yang Nan, Zhang Lei, Li Zhongdong, Li Demin, Sun Lei, Huang Hairong

Oncology Research, Vol.26, No.7, pp. 1015-1022, 2018, DOI:10.3727/096504018X15151486241153

Abstract This study was aimed to investigate the function and mechanism of microRNA-200c (miR-200c) in the progression of non-small cell lung cancer (NSCLC). A total of 76 patients diagnosed as having NSCLC were enrolled in this study. The expression level of miR-200c in NSCLC tissues and cell lines was investigated using the quantitative real-time polymerase chain reaction (RT-qPCR) method. We found that the expression of miR- 200c was significantly reduced in NSCLC tissues and cell lines compared with normal lung tissues and the human bronchial epithelial cell line. Overexpression of miR-200c using the miR-200c mimic significantly… More >

Liang Li^*1, Huijuan Liu^*1, Lianjiang Du^†, Pan Xi^*, Qian Wang^*, Yanqin Li^‡, Di Liu^§

Oncology Research, Vol.26, No.4, pp. 547-556, 2018, DOI:10.3727/096504017X15016337254605

Abstract MicroRNA dysregulation contributes to malignant progression, dissemination, and profound treatment resistance in multiple cancers. miR-449a is recognized as a tumor suppresser. However, the roles of miR-449a in lung cancer initiation and progression are largely unknown. Our study aims to investigate the roles and underlying mechanism of miR-449a in modulating sensitivity to ionizing radiation (IR) in non-small cell lung cancer (NSCLC). Lung cancer cells were transfected with miR-449a mimics or negative control and exposed to IR; the levels of target protein, glycolysis, cell viability, apoptosis, and DNA damage were examined. miR-449a was suppressed in lung cancer… More >

MAHER KURDI^1,*, ALAA ALKHOTANI², ABDULRAHMAN SABBAGH³, EYAD FAIZO⁴, AHMED I. LARY⁵, AHMED K. BAMAGA⁶, MAJID ALMANSOURI⁷, BADR HAFIZ⁸, THAMER ALSHARIF⁹, SALEH BAEESA⁸

Oncology Research, Vol.32, No.6, pp. 1037-1045, 2024, DOI:10.32604/or.2024.051112

Abstract Background: The dysregulation of Isocitrate dehydrogenase (IDH) and the subsequent production of 2-Hydroxyglutrate (2HG) may alter the expression of epigenetic proteins in Grade 4 astrocytoma. The interplay mechanism between IDH, O-6-methylguanine-DNA methyltransferase (MGMT)-promoter methylation, and protein methyltransferase proteins-5 (PRMT5) activity, with tumor progression has never been described. Methods: A retrospective cohort of 34 patients with G4 astrocytoma is classified into IDH-mutant and IDH-wildtype tumors. Both groups were tested for MGMT-promoter methylation and PRMT5 through methylation-specific and gene expression PCR analysis. Inter-cohort statistical significance was evaluated. Results: Both IDH-mutant WHO grade 4 astrocytomas (n = 22, 64.7%) and IDH-wildtype… More > Graphic Abstract

Aneel Kumar¹, Mahesh Kumar¹, Amir Mahmood Soomro¹, Laveet Kumar^2,*

Energy Engineering, Vol.121, No.6, pp. 1439-1457, 2024, DOI:10.32604/ee.2024.049977

Abstract Electric vehicles (EVs) are the most interesting and innovative technology in the 21st century because of their enormous advantages, both technically and economically. Their emissions rate compared to fuel-based vehicles is negligible as they do not consume fuel and hence do not emit any harmful gases. However, their bulk production, adoption and lack of charging stations increase the stress of power stations due to modern-day lifestyles. If Electric vehicles demand increases drastically then conventional power stations will not bear their demand and if they generate electricity by conventional means it will be very costly and… More >

Yuanjun Dai, Haonan Li, Baohua Li^*

Energy Engineering, Vol.121, No.6, pp. 1607-1636, 2024, DOI:10.32604/ee.2024.047255

Abstract This paper addresses the micro wind-hydrogen coupled system, aiming to improve the power tracking capability of micro wind farms, the regulation capability of hydrogen storage systems, and to mitigate the volatility of wind power generation. A predictive control strategy for the micro wind-hydrogen coupled system is proposed based on the ultra-short-term wind power prediction, the hydrogen storage state division interval, and the daily scheduled output of wind power generation. The control strategy maximizes the power tracking capability, the regulation capability of the hydrogen storage system, and the fluctuation of the joint output of the wind-hydrogen… More >

Nugroho Agung Pambudi^1,2,4,*, Andrew Chapman, Alfan Sarifudin^1,3, Desita Kamila Ulfa⁴, Iksan Riva Nanda⁵

Energy Engineering, Vol.121, No.5, pp. 1143-1159, 2024, DOI:10.32604/ee.2024.047555

Abstract One of the impacts of the Fukushima disaster was the shutdown of all nuclear power plants in Japan, reaching zero production in 2015. In response, the country started importing more fossil energy including coal, oil, and natural gas to fill the energy gap. However, this led to a significant increase in carbon emissions, hindering the efforts to reduce its carbon footprint. In the current situation, Japan is actively working to balance its energy requirements with environmental considerations, including the utilization of hydrogen fuel. Therefore, this paper aims to explore the feasibility and implications of using… More >

Yang Li^1,2, Jianjun Zhao², Xiaolong Yang², He Wang^1,*, Yuyan Wang¹

Energy Engineering, Vol.121, No.5, pp. 1263-1289, 2024, DOI:10.32604/ee.2024.046784

Abstract Distributed photovoltaic (PV) is one of the important power sources for building a new power system with new energy as the main body. The rapid development of distributed PV has brought new challenges to the operation of distribution networks. In order to improve the absorption ability of large-scale distributed PV access to the distribution network, the AC/DC hybrid distribution network is constructed based on flexible interconnection technology, and a coordinated scheduling strategy model of hydrogen energy storage (HS) and distributed PV is established. Firstly, the mathematical model of distributed PV and HS system is established,… More >

Yashan Feng¹, Yafang Tian¹, Yongxin Yang¹, Yufang Zhang¹, Haiwei Guo¹, Jing’an Li^2,*

CMC-Computers, Materials & Continua, Vol.79, No.1, pp. 263-278, 2024, DOI:10.32604/cmc.2024.047004

Abstract Electroactive anticorrosion coatings are specialized surface treatments that prevent or minimize corrosion. The study employs strategic thermodynamic equilibrium calculations to pioneer a novel factor in corrosion protection. A first-time proposal, the total acidity (TA) potential of the hydrogen (pH) concept significantly shapes medical magnesium alloys. These coatings are meticulously designed for robust corrosion resistance, blending theoretical insights and practical applications to enhance our grasp of corrosion prevention mechanisms and establish a systematic approach to coating design. The groundbreaking significance of this study lies in its innovative integration of the TA/pH concept, which encompasses the TA/pH… More >