Wanjun Yu*, Weidong Peng*, Hanyun Sha†, Jipeng Li‡
Oncology Research, Vol.27, No.5, pp. 623-628, 2019, DOI:10.3727/096504018X15420734828058
Abstract Circular RNAs (circRNAs) represent a new class of noncoding RNAs that is involved in the development
of cancer. However, little is known about their role in chemoresistance. In the present study, we found that
hsa_circ_0003998 expression levels in lung adenocarcinoma (LAD) tissues and docetaxel-resistant cell lines
(A549/DTX and H1299/DTX) were upregulated. Knockdown of hsa_circ_0003998 decreased chemoresistance, inhibited proliferation, and enhanced apoptosis in docetaxel-resistant LAD cells. Moreover, by using
bioinformatics and luciferase reporter assays, we found that miR-326 was a direct target of hsa_circ_0003998.
Functional analysis revealed that miR-326 mediated the effect of hsa_circ_0003998 on chemosensitivity. Our
findings provide a molecular… More >
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