Liqiong Chen¹, Kui Zhao¹, Kai Zhang^1,*, Duo Xv¹, Hongxvan Hu², Guoguang Ma¹, Wenwen Zhan³

Energy Engineering, Vol.121, No.8, pp. 2143-2165, 2024, DOI:10.32604/ee.2024.049362

Abstract The leakage gas from a buried natural gas pipelines has the great potential to cause economic losses and environmental pollution owing to the complexity of the mountainous environment. In this study, computational fluid dynamics (CFD) method was applied to investigate the diffusion law and hazard range of buried natural gas pipeline leakage in mountainous environment. Based on cloud chart, concentration at the monitoring site and hazard range of lower explosion limit (LEL) and upper explosion limit (UEL), the influences of leakage hole direction and shape, soil property, burial depth, obstacle type on the diffusion law… More >

ANA S. CVETANOVIC^1,2,*, MATTEO LAMBERTINI^3,4, KEVIN PUNIE⁵, GORANA G. MATOVINA BRKO⁶, NIKOLA D. ZIVKOVIC^7,8, MAJA J. POPOVIC^6,9, MARIJANA M. MILOVIC KOVACEVIC¹⁰, LAZAR S. POPOVIC^6,9

Oncology Research, Vol.32, No.8, pp. 1309-1322, 2024, DOI:10.32604/or.2024.049743

Abstract Oncofertility is an extremely significant topic that is increasingly being discussed owing to increased evidence indicating that fertility preservation does not affect the treatment outcomes of patients with cancer but significantly contributes to preserving life quality. The effect of chemotherapy can range from minimal effects to complete ovarian atrophy. Limited data are available on the effects of monoclonal antibodies and targeted therapies on the ovaries and fertility. Temporary ovarian suppression by administering a gonadotropin-releasing hormone agonist (GnRHa) during chemotherapy decreases the gonadotoxic effect of chemotherapy, thereby diminishing the chance of developing premature ovarian insufficiency (POI).… More > Graphic Abstract

Mahatir Ahmed Tusher¹, Saket Choudary Kongara¹, Sagar Dhanraj Pande², SeongKi Kim^3,*, Salil Bharany^4,*

CMC-Computers, Materials & Continua, Vol.79, No.3, pp. 4063-4080, 2024, DOI:10.32604/cmc.2024.049007

Abstract The challenging task of handwriting style synthesis requires capturing the individuality and diversity of human handwriting. The majority of currently available methods use either a generative adversarial network (GAN) or a recurrent neural network (RNN) to generate new handwriting styles. This is why these techniques frequently fall short of producing diverse and realistic text pictures, particularly for terms that are not commonly used. To resolve that, this research proposes a novel deep learning model that consists of a style encoder and a text generator to synthesize different handwriting styles. This network excels in generating conditional… More >

Widad Elbakri¹, Maheyzah Md. Siraj^1,*, Bander Ali Saleh Al-rimy¹, Sultan Noman Qasem², Tawfik Al-Hadhrami³

CMC-Computers, Materials & Continua, Vol.79, No.3, pp. 3725-3756, 2024, DOI:10.32604/cmc.2024.048105

Abstract Cloud computing environments, characterized by dynamic scaling, distributed architectures, and complex workloads, are increasingly targeted by malicious actors. These threats encompass unauthorized access, data breaches, denial-of-service attacks, and evolving malware variants. Traditional security solutions often struggle with the dynamic nature of cloud environments, highlighting the need for robust Adaptive Cloud Intrusion Detection Systems (CIDS). Existing adaptive CIDS solutions, while offering improved detection capabilities, often face limitations such as reliance on approximations for change point detection, hindering their precision in identifying anomalies. This can lead to missed attacks or an abundance of false alarms, impacting overall… More >

Dina Polosukhina^*, Harold D. Love^*†, Harold L. Moses^‡§¶#, Ethan Lee^**††, Roy Zent^{†§**‡‡}, Peter E. Clark^*‡

Oncology Research, Vol.25, No.9, pp. 1653-1664, 2017, DOI:10.3727/096504017X14992942781895

Abstract Wilms tumor (WT) is the most common renal malignancy in children and the fourth most common pediatric solid malignancy in the US. Although the mechanisms underlying the WT biology are complex, these tumors most often demonstrate activation of the canonical Wnt/β-catenin pathway. We and others have shown that constitutive activation of β-catenin restricted to the renal epithelium is sufficient to induce primitive renal epithelial tumors, which resemble human WT. Here we demonstrate that pharmacologic inhibition of β-catenin gene transcription with pyrvinium inhibits tumor growth and metastatic progression in a murine model of WT. Cellular invasion More >

Kazuyoshi Kawakami^*, Takashi Yokokawa^*, Kazuo Kobayashi^*, Takahito Sugisaki^*, Kenichi Suzuki^*, Mitsukuni Suenaga^†, Kensei Yamaguchi^†, Ayaka Inoue^‡, Yoshiaki Machida^‡, Toshiharu Yamaguchi^†, Toshihiro Hama^*

Oncology Research, Vol.25, No.9, pp. 1625-1631, 2017, DOI:10.3727/096504017X15012905098071

Abstract Adherence has become an important issue in modern oncology treatment. Most studies have included heterogeneous target tumor types, regimens, and therapy settings. Our study focused on capecitabine during capecitabine plus oxaliplatin (XELOX) treatment as an adjuvant therapy for colorectal cancer. The main aims of this study were to evaluate real-life adherence to capecitabine and to investigate candidate factors that might decrease adherence. We studied 338 consecutive patients who received XELOX treatment between December 1, 2011, and April 30, 2015, at the Cancer Institute Hospital of the Japanese Foundation for Cancer Research. Our study assessed adherence… More >

VIRAAJ VISHNU PRASAD, JENNIFER SALLY SAMSON, VENKATACHALAM DEEPA PARVATHI^*

BIOCELL, Vol.48, No.5, pp. 693-706, 2024, DOI:10.32604/biocell.2024.048776

Abstract Physical activity and exercise have several beneficial roles in enhancing both physiological and psychological well-being of an individual. In addition to aiding the regulation of aerobic and anaerobic metabolism, exercise can stimulate the synthesis of exerkine hormones in the circulatory system. Among several exerkines that have been investigated for their therapeutic potential, Brain-derived neurotrophic factor (BDNF) is considered the most promising candidate, especially in the management of neurodegenerative diseases. Owing to the ability of physical activity to enhance BDNF synthesis, several experimental studies conducted so far have validated this hypothesis and produced satisfactory results at More > Graphic Abstract

NIKHIL R. MENE¹, SARITA KALLA^1,*, Z.V.P. MURTHY^1,*

Journal of Polymer Materials, Vol.39, No.3-4, pp. 307-323, 2022, DOI:10.32381/JPM.2022.39.3-4.9

Abstract Membrane distillation-crystallization (MDC) is presented as a novel technique in the treatment of waste concentrated water which produces valuable crystals along with pure water. In the present study, multi-walled carbon nanotubes (MWCNT)/polyvinylidene fluoride (PVDF) flat sheet membranes were prepared via the wet phase inversion method and applied in MDC for the treatment of pharmaceutical waste. The pure and modified membrane surface properties are characterized with the help of SEM, FTIR, and contact angle measurement. The present work reported the effect of MWCNT content and feed temperature on the MDCperformance and measured pure water flux and More >

Chein-Shan Liu¹, Chung-Lun Kuo¹, Chih-Wen Chang^2,*

CMES-Computer Modeling in Engineering & Sciences, Vol.139, No.3, pp. 3189-3208, 2024, DOI:10.32604/cmes.2023.046002

Abstract To solve the Laplacian problems, we adopt a meshless method with the multiquadric radial basis function (MQ-RBF) as a basis whose center is distributed inside a circle with a fictitious radius. A maximal projection technique is developed to identify the optimal shape factor and fictitious radius by minimizing a merit function. A sample function is interpolated by the MQ-RBF to provide a trial coefficient vector to compute the merit function. We can quickly determine the optimal values of the parameters within a preferred rage using the golden section search algorithm. The novel method provides the More >

Ahmed Hassan Abdou^1,*, Omar Abdullah Alkhateeb², Hossam Eldin Hamed Mansour³, Hesham S. Ghazzawy⁴, Muayad Saud Albadrani⁵, Nadi Awad Al-harbi⁶, Wasimah B. Al-Shammari⁷, Khaled Abdelaal^8,*

Phyton-International Journal of Experimental Botany, Vol.92, No.12, pp. 3305-3321, 2023, DOI:10.32604/phyton.2023.044780

Abstract Plant growth-promoting bacteria (PGPB) play an important role in improving agricultural production under several abiotic stress factors. PGPB can be used to increase crop growth and development through hormonal balance and increase nutrient uptake. The positive effect of PGPB may be due to its pivotal role in morphophysiological and biochemical characteristics like leaf number, leaf area, and stem length. Furthermore, relative water content, chlorophyll content, carotenoids, antioxidant enzymes, and plant hormones were improved with PGPB treatment. Crop yield and yield components were also increased with PGPB treatment in numerous crops. The anatomical structure of plant… More >