STEPHEN E. LANGABEER^*

Oncology Research, Vol.32, No.9, pp. 1423-1427, 2024, DOI:10.32604/or.2024.051218 - 23 August 2024

Abstract Hairy cell leukemia (HCL) is an uncommon mature B-cell malignancy characterized by a typical morphology, immunophenotype, and clinical profile. The vast majority of HCL patients harbor the canonical BRAF V600E mutation which has become a rationalized target of the subsequently deregulated RAS-RAF-MEK-MAPK signaling pathway in HCL patients who have relapsed or who are refractory to front-line therapy. However, several HCL patients with a classical phenotype display non-canonical BRAF mutations or rearrangements. These include sequence variants within alternative exons and an oncogenic fusion with the IGH gene. Care must be taken in the molecular diagnostic work-up of patients More >

LITING WEN^#, XIAOXIA ZENG^#, PEIXIONG CHEN, DAPENG ZHAO, YANGYANG LI, XIANHAI ZENG^*

BIOCELL, Vol.48, No.6, pp. 991-999, 2024, DOI:10.32604/biocell.2024.050219 - 10 June 2024

Abstract Background: Cochlear hair cell injury is a common pathological feature of hearing loss. The basic helix-loop-helix family, member e40 (Bhlhe40), a gene belonging to the basic helix-loop-helix (bHLH) family, exhibits strong transcriptional repression activity. Methods: Oxidative damage, in House Ear Institute-Organ of Corti 1 (HEI‑OC1) cells, was caused using hydrogen peroxide (HO). The Ad-Bhlhe40 particles were constructed to overexpress Bhlhe40 in HEI-OC1 cells. Various assays including cell counting kit-8 (CCK-8), terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling assay (TUNEL), flow cytometry, immunofluorescence, and corresponding commercial kits were employed to investigate the impacts of Bhlhe40 on cell viability, apoptosis,… More > Graphic Abstract

Lei Zhu^1,#, Lihe Hou^1,3,#, Yu Zhang¹, Yang Jiang¹, Yi Wang^1,2, Meiping Zhang^1,2, Mingzhu Zhao^1,2,*, Kangyu Wang^1,2,*

Phyton-International Journal of Experimental Botany, Vol.93, No.2, pp. 313-327, 2024, DOI:10.32604/phyton.2024.047938 - 27 February 2024

Abstract Panax ginseng C. A. Mey. is an important plant species used in traditional Chinese medicine, whose primary active ingredient is a ginsenoside. Ginsenoside biosynthesis is not only regulated by transcription factors but also controlled by a variety of structural genes. Nonetheless, the molecular mechanism underlying ginsenoside biosynthesis has always been a topic in the discussion of ginseng secondary metabolites. Squalene epoxidase (SQE) is a key enzyme in the mevalonic acid pathway, which affects the biosynthesis of secondary metabolites such as terpenoid. Using ginseng transcriptome, expression, and ginsenoside content databases, this study employed bioinformatic methods to systematically… More >

FU-MING TSAI¹, PING-HSUN LU^2,3, LU-KAI WANG⁴, CHAN-YEN KUO¹, MAO-LIANG CHEN¹, CHUN-HUA WANG^5,6,*

BIOCELL, Vol.47, No.8, pp. 1793-1802, 2023, DOI:10.32604/biocell.2023.030093 - 28 August 2023

Abstract Background: Cisplatin is a chemotherapeutic agent commonly used clinically for the treatment of various human cancers. Patients often reduce the use of cisplatin due to its side effects, which in turn affects its treatment. This study explored the mechanism of action of safflower extract as an adjuvant traditional Chinese medicine for chemotherapy. Methods: Primary human follicle dermal papilla cells (HFDPCs) were used as target cells for cisplatin-induced damage to hair cells. Western blotting was used to investigate the molecular targets of cisplatin and safflower extract in causing HFDPCs damage. Cell survival and cell cycle were… More >

Saleh Naif Almuayqil¹, Reham Arnous^2,*, Noha Sakr³, Magdy M. Fadel³

CMC-Computers, Materials & Continua, Vol.75, No.3, pp. 5177-5192, 2023, DOI:10.32604/cmc.2023.038625 - 29 April 2023

Abstract Skin segmentation participates significantly in various biomedical applications, such as skin cancer identification and skin lesion detection. This paper presents a novel framework for segmenting the skin. The framework contains two main stages: The first stage is for removing different types of noises from the dermoscopic images, such as hair, speckle, and impulse noise, and the second stage is for segmentation of the dermoscopic images using an attention residual U-shaped Network (U-Net). The framework uses variational Autoencoders (VAEs) for removing the hair noises, the Generative Adversarial Denoising Network (DGAN-Net), the Denoising U-shaped U-Net (D-U-NET), and… More >

Sahar Saleh^1,2, Mohd Haizal Jamaluddin^1,*, Bader Alali^3,4, Ayman A. Althuwayb⁴

CMC-Computers, Materials & Continua, Vol.74, No.3, pp. 5983-5999, 2023, DOI:10.32604/cmc.2023.035585 - 28 December 2022

Abstract Compact fifth-generation (5G) low-frequency band filtering antennas (filtennas) with stable directive radiation patterns, improved bandwidth (BW), and gain are designed, fabricated, and tested in this research. The proposed filtennas are achieved by combining the predesigned compact 5G (5.975 – 7.125 GHz) third-order uniform and non-uniform transmission line hairpin bandpass filters (UTL and NTL HPBFs) with the compact ultrawide band Vivaldi tapered slot antenna (UWB VTSA) in one module. The objective of this integration is to enhance the performance of 5.975 – 7.125 GHz filtennas which will be suitable for modern mobile communication applications by exploiting the benefits… More >

Chyi-Yeu Lin^1,2,3, Bahrudin¹, Salman Masroor^1,*

CMC-Computers, Materials & Continua, Vol.74, No.3, pp. 4881-4900, 2023, DOI:10.32604/cmc.2023.032837 - 28 December 2022

Abstract Functionally impaired people always have difficulty accomplishing activities of daily living. In this regard, tasks including toileting and bathing have a higher prevalence rate of injuries and greater risk of falling. In this study, a body-transfer wheelchair was developed to assist people in transferring from bed to wheelchair for bathing, and toileting. The body-transfer wheelchair is a semi-automatic wheelchair that has features such as a controlled leg and backrest, linkage commode slot, and height adjustment. The wheelchair consists of a seat and a main frame that can be detached to enable bathtub transfer. This mechanism… More >

Oliver Tusevski^1,*, Marija Todorovska¹, Jasmina Petreska Stanoeva², Marina Stefova², Sonja Gadzovska Simic¹

Phyton-International Journal of Experimental Botany, Vol.92, No.3, pp. 921-941, 2023, DOI:10.32604/phyton.2023.024995 - 29 November 2022

Abstract Three Hypericum perforatum hairy root lines (HR B, HR F and HR H) along with non-transformed roots were analyzed for phenolic compounds composition and in vitro enzyme inhibitory properties. In silico molecular modeling was performed to predict the interactions of the most representative phenolic compounds in HR clones with enzymes related to depression, neurodegeneration and diabetes. Chromatographic analyses revealed that HR clones represent an efficient source of quinic acid and hydroxybenzoic acids, epicatechin and procyanidin derivatives, quercetin and kaempferol glycosides, as well numerous xanthones. In vitro antidepressant activity of HR extracts through monoamine oxidase A (MAO-A) inhibition was attributed… More >

Mohsen Bakouri^1,2,*

CMC-Computers, Materials & Continua, Vol.73, No.2, pp. 2441-2456, 2022, DOI:10.32604/cmc.2022.025106 - 16 June 2022

Abstract In this work, we developed and implemented a voice control algorithm to steer smart robotic wheelchairs (SRW) using the neural network technique. This technique used a network in network (NIN) and long short-term memory (LSTM) structure integrated with a built-in voice recognition algorithm. An Android Smartphone application was designed and configured with the proposed method. A Wi-Fi hotspot was used to connect the software and hardware components of the system in an offline mode. To operate and guide SRW, the design technique proposed employing five voice commands (yes, no, left, right, no, and stop) via… More >

Qazwan Abdullah^1,2,*, Ömer Aydoĝdu², Adeeb Salh³, Nabil Farah⁴, Md Hairul Nizam Talib⁴, Taha Sadeq⁵, Mohammed A. A. Al-Mekhalfi³, Abdu Saif⁶

CMC-Computers, Materials & Continua, Vol.69, No.3, pp. 4025-4042, 2021, DOI:10.32604/cmc.2021.018798 - 24 August 2021

Abstract The multilayer structure is a promising technique used to minimize the size of planar microstrip filters. In the flexible design and incorporation of other microwave components, multilayer band-pass filter results in better and enhanced dimensions. This paper introduces a microstrip fifth-generation (5G) low-frequency band of 2.52–2.65 GHz using a parallel-coupled line (PCL) Bandpass filter and multilayer (ML) hairpin Bandpass filter. The targeted four-pole resonator has a center frequency of 2.585 GHz with a bandwidth of 130 MHz. The filters are designed with a 0.1 dB passband ripple with a Chebyshev response. The hairpin-line offers compact… More >