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    ARTICLE

    An Intelligent Prediction Model for Target Protein Identification in Hepatic Carcinoma Using Novel Graph Theory and ANN Model

    G. Naveen Sundar1, Stalin Selvaraj2, D. Narmadha1, K. Martin Sagayam3, A. Amir Anton Jone3, Ayman A. Aly4, Dac-Nhuong Le5,6,*

    CMES-Computer Modeling in Engineering & Sciences, Vol.133, No.1, pp. 31-46, 2022, DOI:10.32604/cmes.2022.019914

    Abstract Hepatocellular carcinoma (HCC) is one major cause of cancer-related mortality around the world. However, at advanced stages of HCC, systematic treatment options are currently limited. As a result, new pharmacological targets must be discovered regularly, and then tailored medicines against HCC must be developed. In this research, we used biomarkers of HCC to collect the protein interaction network related to HCC. Initially, DC (Degree Centrality) was employed to assess the importance of each protein. Then an improved Graph Coloring algorithm was used to rank the target proteins according to the interaction with the primary target More >

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