Li Ji^1,2, Jiawei Mao^1,3, Ruixiang Li^1,*, Jiaqi Xu^1,*

Journal of Renewable Materials, Vol.13, No.9, pp. 1683-1706, 2025, DOI:10.32604/jrm.2025.02025-0043 - 22 September 2025

Abstract Primary diamines play an important role in the chemical industry, where they are widely used as raw materials for the manufacture of pharmaceuticals and polymers. Currently, primary diamines are mainly derived from petroleum, while harsh or toxic conditions are often needed. Biomass is abundant and renewable , which serves as a promising alternative raw material to produce primary diamines. This review primarily focuses on the synthesis of 2,5-bis(aminomethyl)furan (BAMF), a bio-based diamine with potential as a biomonomer for polyamides and polyureas. Specifically, this review emphasizes the synthesis of BAMF from three biomass-derived alcohols and aldehydes,… More > Graphic Abstract

Zhuoqun Xia¹, Hangyu Hu¹, Wenjing Li^2,3, Qisheng Jiang¹, Lan Pu¹, Yicong Shu¹, Arun Kumar Sangaiah^4,5,*

CMES-Computer Modeling in Engineering & Sciences, Vol.144, No.2, pp. 2683-2683, 2025, DOI:10.32604/cmes.2025.069871 - 31 August 2025

Abstract This article has no abstract. More >

Haniif Prasetiawan^1,2,*, Dewi Selvia Fardhyanti¹, Hadiyanto², Widya Fatriasari³

Journal of Renewable Materials, Vol.13, No.7, pp. 1347-1366, 2025, DOI:10.32604/jrm.2025.02024-0070 - 22 July 2025

Abstract Bio-oil is a renewable fuel that can be obtained from biomass waste, such as empty palm fruit bunches, sugarcane bagasse, and rice husks. Within a biorefinery framework, bio-oil had not met the standards as a fuel due to the presence of impurities like corrosive phenol. Therefore, the separation of phenol from bio-oil is essential and can be achieved using the extraction method. In this study, biomass wastes (empty fruit bunches of oil palm, sugarcane bagasse, and rice husk) were pyrolyzed in a biorefinery framework to produce bio-oil, which was then refined through liquid-liquid extraction with… More >

Md Shakhawat Hossain^1,2,#,*, Md Sahilur Rahman^2,#, Munim Ahmed², Anowar Hussen³, Zahid Ullah⁴, Mona Jamjoom⁵

CMC-Computers, Materials & Continua, Vol.84, No.2, pp. 3193-3215, 2025, DOI:10.32604/cmc.2025.065230 - 03 July 2025

Abstract One in every eight men in the US is diagnosed with prostate cancer, making it the most common cancer in men. Gleason grading is one of the most essential diagnostic and prognostic factors for planning the treatment of prostate cancer patients. Traditionally, urological pathologists perform the grading by scoring the morphological pattern, known as the Gleason pattern, in histopathology images. However, this manual grading is highly subjective, suffers intra- and inter-pathologist variability and lacks reproducibility. An automated grading system could be more efficient, with no subjectivity and higher accuracy and reproducibility. Automated methods presented previously… More >

Giuseppe Carota¹, Lucia Di Pietro^2,3, Vincenzo Cardaci⁴, Anna Privitera^1,2, Francesco Bellia¹, Valentina Di Pietro⁵, Giuseppe Lazzarino¹, Barbara Tavazzi⁶, Angela Maria Amorini¹, Giacomo Lazzarino⁶, Giuseppe Caruso^6,7,*

BIOCELL, Vol.49, No.4, pp. 563-578, 2025, DOI:10.32604/biocell.2025.062176 - 30 April 2025

Abstract Carnosine (β-alanyl-L-histidine) is a naturally occurring endogenous peptide widely distributed in excitable tissues, such as the heart and brain. Over the years, several beneficial effects of carnosine have been discussed well in scientific literature. In particular, this dipeptide is well-known for its antioxidant, anti-inflammatory, and anti-aggregation activities. It is of great interest in the context of numerous systemic and neurodegenerative diseases, besides performing important “side activities” such as metal chelation and pH-buffering. Despite a plethora of preclinical and clinical data supporting carnosine’s therapeutic potential, researchers are still searching for new pharmacological targets that better highlight More >

Tariq Mahmood^1,2, Tanzila Saba¹, Faten S. Alamri^3,*, Alishba Tahir⁴, Noor Ayesha⁵

CMC-Computers, Materials & Continua, Vol.83, No.1, pp. 1173-1193, 2025, DOI:10.32604/cmc.2025.061150 - 26 March 2025

Abstract Innovation in learning algorithms has made retinal vessel segmentation and automatic grading techniques crucial for clinical diagnosis and prevention of diabetic retinopathy. The traditional methods struggle with accuracy and reliability due to multi-scale variations in retinal blood vessels and the complex pathological relationship in fundus images associated with diabetic retinopathy. While the single-modal diabetic retinopathy grading network addresses class imbalance challenges and lesion representation in fundus image data, dual-modal diabetic retinopathy grading methods offer superior performance. However, the scarcity of dual-modal data and the lack of effective feature fusion methods limit their potential due to… More >

Snir Dekalo^1,2, Ohad Mazliah², Eyal Barkai^1,2, Yuval Bar-Yosef^1,2, Haim Herzberg^1,2, Tomer Bashi^1,2, Ibrahim Fahoum^2,3, Sophie Barnes^2,4, Mario Sofer^1,2, Ofer Yossepowitch^1,2, Gal Keren-Paz^1,2, Roy Mano^1,2

Canadian Journal of Urology, Vol.31, No.4, pp. 11955-11962, 2024

Abstract Introduction: Most men diagnosed with very-low and low-risk prostate cancer are candidates for active surveillance; however, there is still a misclassification risk. We examined whether PI-RADS category 4 or 5 combined with ISUP 1 on prostate biopsy predicts upgrading and/ or adverse pathology at radical prostatectomy.
Materials and methods: A total of 127 patients had ISUP 1 cancer on biopsy after multiparametric MRI (mpMRI) and then underwent radical prostatectomy. We then evaluated them for ISUP upgrading and/or adverse pathology on radical prostatectomy.
Results: Eight-nine patients (70%) were diagnosed with PI-RADS 4 or 5 lesions. ISUP upgrading was significantly… More >

GERHARD HAMILTON^*, MARIE-THERESE EGGERSTORFER, SANDRA STICKLER

Oncology Research, Vol.32, No.8, pp. 1257-1264, 2024, DOI:10.32604/or.2024.051653 - 17 July 2024

Abstract The Kirsten rat sarcoma virus—son of sevenless 1 (KRAS-SOS1) axis drives tumor growth preferentially in pancreatic, colon, and lung cancer. Now, KRAS G12C mutated tumors can be successfully treated with inhibitors that covalently block the cysteine of the switch II binding pocket of KRAS. However, the range of other KRAS mutations is not amenable to treatment and the G12C-directed agents Sotorasib and Adragrasib show a response rate of only approximately 40%, lasting for a mean period of 8 months. One approach to increase the efficacy of inhibitors is their inclusion into proteolysis-targeting chimeras (PROTACs), which… More > Graphic Abstract

Zhuoqun Xia¹, Hangyu Hu¹, Wenjing Li^2,3, Qisheng Jiang¹, Lan Pu¹, Yicong Shu¹, Arun Kumar Sangaiah^4,5,*

CMES-Computer Modeling in Engineering & Sciences, Vol.140, No.1, pp. 409-430, 2024, DOI:10.32604/cmes.2024.030052 - 16 April 2024

Abstract Early screening of diabetes retinopathy (DR) plays an important role in preventing irreversible blindness. Existing research has failed to fully explore effective DR lesion information in fundus maps. Besides, traditional attention schemes have not considered the impact of lesion type differences on grading, resulting in unreasonable extraction of important lesion features. Therefore, this paper proposes a DR diagnosis scheme that integrates a multi-level patch attention generator (MPAG) and a lesion localization module (LLM). Firstly, MPAG is used to predict patches of different sizes and generate a weighted attention map based on the prediction score and… More >

Junhui Li¹, Xuanzhong Luo^1,2, Changxing Ge³, Cuiping Li^1,*, Changrong Wang⁴

Energy Engineering, Vol.121, No.4, pp. 869-893, 2024, DOI:10.32604/ee.2024.029722 - 26 March 2024

Abstract Peak load and wind energy emission pressure rise more as wind energy penetration keeps growing, which affects the stabilization of the PS (power system). This paper suggests integrated optimal dispatching of thermal power generators and BESS (battery energy storage system) taking wind energy emission grading punishment and deep peak clipping into consideration. Firstly, in order to minimize wind abandonment, a hierarchical wind abandonment penalty strategy based on fuzzy control is designed and introduced, and the optimal grid-connected power of wind energy is determined as a result of minimizing the peak cutting cost of the system.… More > Graphic Abstract