BINGJIE LIN¹, XIAOBO YING², CHUANLING ZHANG^3,*, GUOJUN ZHANG^1,*

BIOCELL, Vol.48, No.11, pp. 1613-1623, 2024, DOI:10.32604/biocell.2024.053652 - 07 November 2024

Abstract Objectives: This study explores the protective effects of glycyrrhizic acid (GA) on sepsis-induced cellular damage and inflammation in acute lung injury (ALI), specifically through the modulation of the sirtuin 1 (SIRT1) and high mobility group box 1 (HMGB1) pathway. Methods: The study employed two experimental models: lipopolysaccharide (LPS)-induced BEAS-2B human lung epithelial cells and cecal ligation and puncture (CLP) rats, to simulate sepsis conditions. The cell model involved treatments with LPS, GA, control siRNA (si-NC), and SIRT1-specific siRNA (si-SIRT1). Evaluations included cell viability, apoptosis, and cytokine production. In the rat model, treatments included GA and… More >

Tahsin Shoala¹, Basma H. Amin², Ismail A. S. Rashid³, Fayz A. Abdel-Rahman³, Mohamed E. Khalil³, Khamis Youssef^3,*

Phyton-International Journal of Experimental Botany, Vol.92, No.4, pp. 1139-1152, 2023, DOI:10.32604/phyton.2023.026515 - 06 January 2023

Abstract Production of peaches (Prunus persica (L.) Batsch) for both local market and export is increasing each year in Egypt. Brown rot disease, caused by Monilinia laxa and Monilinia fructigena, is considered one of the most important postharvest rots affecting peaches in Egypt and economic losses are increasing. Antifungal activity of glycyrrhizic acid nanoparticles (GA-NPs) and glycyrrhizic acid (GA) at 0.2 and 0.4 mmol/L was investigated as a control for both these brown rot pathogens on peach fruits in both in vitro and in vivo studies. In the in vitro studies, GA-NPs were the most effective as shown by the ability to… More >

Zhang JT¹, B Xu¹, M Li²

Phyton-International Journal of Experimental Botany, Vol.80, pp. 161-166, 2011, DOI:10.32604/phyton.2011.80.161

Abstract The content of active compounds in Glycyrrhiza uralensis may vary among populations in different regions, and be influenced by environmental variables. We determined the effects of soil and climate on contents of glycyrrhizic acid and liquiritin in various populations of Glycyrrhiza uralensis. Fifty individuals from 5 rangeland populations in arid and semi-arid regions of North China were collected and analyzed. The contents of glycyrrhizic acid and liquiritin were determined using the HPLC method. Contents of glycyrrhizic acid and liquiritin varied significantly among populations as follows: Chifeng > Hangjinqi > Minqin > Aletai > Kashi. These contents were More >