Maheen Anwar¹, Saima Farhan¹, Yasin Ul Haq², Waqar Azeem³, Muhammad Ilyas⁴, Razvan Cristian Voicu^5,*, Muhammad Hassan Tanveer⁵

CMC-Computers, Materials & Continua, Vol.84, No.2, pp. 3477-3502, 2025, DOI:10.32604/cmc.2025.065141 - 03 July 2025

Abstract Glaucoma, a chronic eye disease affecting millions worldwide, poses a substantial threat to eyesight and can result in permanent vision loss if left untreated. Manual identification of glaucoma is a complicated and time-consuming practice requiring specialized expertise and results may be subjective. To address these challenges, this research proposes a computer-aided diagnosis (CAD) approach using Artificial Intelligence (AI) techniques for binary and multiclass classification of glaucoma stages. An ensemble fusion mechanism that combines the outputs of three pre-trained convolutional neural network (ConvNet) models–ResNet-50, VGG-16, and InceptionV3 is utilized in this paper. This fusion technique enhances… More >

Jahanzaib Latif ¹, Ahsan Wajahat¹, Alishba Tahir², Anas Bilal^3,*, Mohammed Zakariah⁴, Abeer Alnuaim⁴

CMES-Computer Modeling in Engineering & Sciences, Vol.143, No.1, pp. 539-567, 2025, DOI:10.32604/cmes.2025.062301 - 11 April 2025

Abstract Glaucoma, a leading cause of blindness, demands early detection for effective management. While AI-based diagnostic systems are gaining traction, their performance is often limited by challenges such as varying image backgrounds, pixel intensity inconsistencies, and object size variations. To address these limitations, we introduce an innovative, nature-inspired machine learning framework combining feature excitation-based dense segmentation networks (FEDS-Net) and an enhanced gray wolf optimization-supported support vector machine (IGWO-SVM). This dual-stage approach begins with FEDS-Net, which utilizes a fuzzy integral (FI) technique to accurately segment the optic cup (OC) and optic disk (OD) from retinal images, even More >

Khursheed Aurangzeb^*, Syed Irtaza Haider, Musaed Alhussein

CMC-Computers, Materials & Continua, Vol.80, No.1, pp. 1381-1405, 2024, DOI:10.32604/cmc.2024.048987 - 18 July 2024

Abstract In this work, we aim to introduce some modifications to the Anam-Net deep neural network (DNN) model for segmenting optic cup (OC) and optic disc (OD) in retinal fundus images to estimate the cup-to-disc ratio (CDR). The CDR is a reliable measure for the early diagnosis of Glaucoma. In this study, we developed a lightweight DNN model for OC and OD segmentation in retinal fundus images. Our DNN model is based on modifications to Anam-Net, incorporating an anamorphic depth embedding block. To reduce computational complexity, we employ a fixed filter size for all convolution layers… More >

Hela Elmannai^1,*, Monia Hamdi¹, Souham Meshoul¹, Amel Ali Alhussan², Manel Ayadi³, Amel Ksibi³

CMES-Computer Modeling in Engineering & Sciences, Vol.140, No.2, pp. 1429-1457, 2024, DOI:10.32604/cmes.2024.048557 - 20 May 2024

Abstract Glaucoma disease causes irreversible damage to the optical nerve and it has the potential to cause permanent loss of vision. Glaucoma ranks as the second most prevalent cause of permanent blindness. Traditional glaucoma diagnosis requires a highly experienced specialist, costly equipment, and a lengthy wait time. For automatic glaucoma detection, state-of-the-art glaucoma detection methods include a segmentation-based method to calculate the cup-to-disc ratio. Other methods include multi-label segmentation networks and learning-based methods and rely on hand-crafted features. Localizing the optic disc (OD) is one of the key features in retinal images for detecting retinal diseases,… More >

D. Dorathy Prema Kavitha¹, L. Francis Raj¹, Sandeep Kautish^2,#, Abdulaziz S. Almazyad³, Karam M. Sallam⁴, Ali Wagdy Mohamed^5,6,*

CMES-Computer Modeling in Engineering & Sciences, Vol.139, No.1, pp. 801-816, 2024, DOI:10.32604/cmes.2023.030902 - 30 December 2023

Abstract The intuitive fuzzy set has found important application in decision-making and machine learning. To enrich and utilize the intuitive fuzzy set, this study designed and developed a deep neural network-based glaucoma eye detection using fuzzy difference equations in the domain where the retinal images converge. Retinal image detections are categorized as normal eye recognition, suspected glaucomatous eye recognition, and glaucomatous eye recognition. Fuzzy degrees associated with weighted values are calculated to determine the level of concentration between the fuzzy partition and the retinal images. The proposed model was used to diagnose glaucoma using retinal images… More >

Jahanzaib Latif¹, Shanshan Tu^1,*, Chuangbai Xiao¹, Anas Bilal², Sadaqat Ur Rehman³, Zohaib Ahmad⁴

CMC-Computers, Materials & Continua, Vol.76, No.1, pp. 1151-1172, 2023, DOI:10.32604/cmc.2023.040152 - 08 June 2023

Abstract Glaucoma is a progressive eye disease that can lead to blindness if left untreated. Early detection is crucial to prevent vision loss, but current manual scanning methods are expensive, time-consuming, and require specialized expertise. This study presents a novel approach to Glaucoma detection using the Enhanced Grey Wolf Optimized Support Vector Machine (EGWO-SVM) method. The proposed method involves preprocessing steps such as removing image noise using the adaptive median filter (AMF) and feature extraction using the previously processed speeded-up robust feature (SURF), histogram of oriented gradients (HOG), and Global features. The enhanced Grey Wolf Optimization More >

Krishna Santosh Naidana, Soubhagya Sankar Barpanda^*

Computer Systems Science and Engineering, Vol.47, No.1, pp. 699-720, 2023, DOI:10.32604/csse.2023.036744 - 26 May 2023

Abstract Glaucoma is a group of ocular atrophy diseases that cause progressive vision loss by affecting the optic nerve. Because of its asymptomatic nature, glaucoma has become the leading cause of human blindness worldwide. In this paper, a novel computer-aided diagnosis (CAD) approach for glaucomatous retinal image classification has been introduced. It extracts graph-based texture features from structurally improved fundus images using discrete wavelet-transformation (DWT) and deterministic tree-walk (DTW) procedures. Retinal images are considered from both public repositories and eye hospitals. Images are enhanced with image-specific luminance and gradient transitions for both contrast and texture improvement.… More >

Somasundaram Devaraj^*, Senthil Kumar Arunachalam

Intelligent Automation & Soft Computing, Vol.36, No.2, pp. 1283-1299, 2023, DOI:10.32604/iasc.2023.033200 - 05 January 2023

Abstract Retinal fundus images are used to discover many diseases. Several Machine learning algorithms are designed to identify the Glaucoma disease. But the accuracy and time consumption performance were not improved. To address this problem Max Pool Convolution Neural Kuan Filtered Tobit Regressive Segmentation based Radial Basis Image Classifier (MPCNKFTRS-RBIC) Model is used for detecting the Glaucoma and Stargardt’s disease by early period using higher accuracy and minimal time. In MPCNKFTRS-RBIC Model, the retinal fundus image is considered as an input which is preprocessed in hidden layer 1 using weighted adaptive Kuan filter. Then, preprocessed retinal… More >

A. Geetha, N. B. Prakash^*

Computer Systems Science and Engineering, Vol.43, No.3, pp. 1041-1055, 2022, DOI:10.32604/csse.2022.023680 - 09 May 2022

Abstract Today, many eye diseases jeopardize our everyday lives, such as Diabetic Retinopathy (DR), Age-related Macular Degeneration (AMD), and Glaucoma. Glaucoma is an incurable and unavoidable eye disease that damages the vision of optic nerves and quality of life. Classification of Glaucoma has been an active field of research for the past ten years. Several approaches for Glaucoma classification are established, beginning with conventional segmentation methods and feature-extraction to deep-learning techniques such as Convolution Neural Networks (CNN). In contrast, CNN classifies the input images directly using tuned parameters of convolution and pooling layers by extracting features.… More >

Anisha Rebinth^1,*, S. Mohan Kumar²

Computer Systems Science and Engineering, Vol.42, No.3, pp. 867-880, 2022, DOI:10.32604/csse.2022.022955 - 08 February 2022

Abstract In this study, a Discriminator Model for Glaucoma Diagnosis (DMGD) using soft computing techniques is presented. As the biomedical images such as fundus images are often acquired in high resolution, the Region of Interest (ROI) for glaucoma diagnosis must be selected at first to reduce the complexity of any system. The DMGD system uses a series of pre-processing; initial cropping by the green channel’s intensity, Spatially Weighted Fuzzy C Means (SWFCM), blood vessel detection and removal by Gaussian Derivative Filters (GDF) and inpainting algorithms. Once the ROI has been selected, the numerical features such as More >