ZHEN WANG¹, JUN FU¹, SAISAI ZHU¹, HAODONG TANG², KUI SHI¹, JIHUA YANG³, MENG WANG³, MENGGE WU¹, DUNFENG QI^1,*

Oncology Research, Vol.32, No.12, pp. 1851-1866, 2024, DOI:10.32604/or.2024.055286 - 13 November 2024

Abstract Background: Pancreatic ductal adenocarcinoma (PDAC) has a rich and complex tumor immune microenvironment (TIME). M2 macrophages are among the most extensively infiltrated immune cells in the TIME and are necessary for the growth and migration of cancers. However, the mechanisms and targets mediating M2 macrophage infiltration in pancreatic cancer remain elusive. Methods: The M2 macrophage infiltration score of patients was assessed using the xCell algorithm. Using weighted gene co-expression network analysis (WGCNA), module genes associated with M2 macrophages were identified, and a predictive model was designed. The variations in immunological cell patterns, cancer mutations, and… More > Graphic Abstract

A. NOEL GRAVINA^1,2, NOELIA D´ELÍA^1,2, LUCIANO A. BENEDINI^2,3,*, PAULA MESSINA^1,2

BIOCELL, Vol.48, No.11, pp. 1517-1520, 2024, DOI:10.32604/biocell.2024.055513 - 07 November 2024

Abstract This article navigates the relationship between biomaterials and osteogenic cell adhesion, highlighting the importance of mimicking the physiological response for bone tissue regeneration. Within this spirit is an initial description of the interaction between osteoblasts and osteoprogenitor cells with the extracellular matrix, explaining the leading role of integrins and cadherins in cell adhesion, and the intracellular signaling pathways elicited. Additionally, there is a focus on the strategies of advanced biomaterials that foster osteogenesis by replicating the native environment, taking advantage of these known specific signaling pathways. The final remarks lay on the need for careful More >

KURT SARTORIUS^1,2,3,*, BENN SARTORIUS⁴, CHERIE WINKLER⁵, ANIL CHUTURGOON², ANNA KRAMVIS¹, PING AN⁵, WEIGANG ZHANG⁶, YUNJIE LU^3,6,7,*

BIOCELL, Vol.48, No.11, pp. 1543-1567, 2024, DOI:10.32604/biocell.2024.055505 - 07 November 2024

Abstract Hepatitis B-associated hepatocellular carcinoma (HBV-HCC) remains an intractable high-mortality solid tumor cancer that accounted for 42% of global HCC cases in 2019. Despite some developments in systemic therapy, only a small subset of late-stage HCC patients responds positively to recently developed therapeutic innovations. MicroRNAs (miRNAs) act as an ancillary epigenetic system that can regulate genome expression in all cancer pathways including HCC. The molecular mechanisms of miRNA regulation in cancer pathogenesis offered researchers a new approach that was widely hoped would translate into miRNA-based drugs and diagnostics. Thirty years on, miRNA-based diagnostic and therapeutic agents… More >

Dongxue Su¹, Jiarui Zheng¹, Yuwei Yi¹, Shuyuan Zhang¹, Luxin Feng¹, Danzeng Quzhen², De Qiong³, Weiwei Zhang¹, Qijian Wang¹, Feng Xu^1,*

Phyton-International Journal of Experimental Botany, Vol.93, No.9, pp. 2317-2337, 2024, DOI:10.32604/phyton.2024.055350 - 30 September 2024

Abstract The multifaceted roles of MYB transcriptional regulators are pivotal in orchestrating the complex processes of secondary metabolism, stress tolerance mechanisms, and life cycle progression and development. This study extensively examined the JrMYB genes using whole genome and transcriptomic data, focusing on identifying putative MYB genes associated with fatty acid metabolism. 126 MYB genes were identified within the walnut genome, characterized by hydrophilic proteins spanning lengths ranging from 78 to 1890 base pairs. Analysis of cis-acting elements within the promoter regions of MYB genes revealed many elements linked to cell development, environmental stress, and phytohormones. Transcriptomic data was utilized… More > Graphic Abstract

Jun Yuan¹, Rongpeng Liu⁴, Xiaoyun Wang^3,*, Haihui Fu^2,*

Phyton-International Journal of Experimental Botany, Vol.93, No.9, pp. 2267-2284, 2024, DOI:10.32604/phyton.2024.055338 - 30 September 2024

Abstract Cadmium (Cd) has seriously affected the quality of traditional Chinese medicinal material Salvia miltiorrhiza in recent years, threatening human health. The physiological and metabolic profiles of S. miltiorrhiza in response to Cd stress have been revealed in previous studies. However, transcriptional and post-transcriptional regulation in response to different degrees of Cd (0, 25, 50, and 100 mg/kg) stress in S. miltiorrhiza remains unclear. Here, transcriptome atlas in S. miltiorrhiza under different degrees of Cd Stress was unveiled using RNA sequencing (RNA-seq). These results showed that the profiles of gene expression were different in the response to Cd treatment. Defense More >

Esra Arslan Yuksel^*

Phyton-International Journal of Experimental Botany, Vol.93, No.9, pp. 2189-2207, 2024, DOI:10.32604/phyton.2024.055053 - 30 September 2024

Abstract Heavy metal contamination in the environment, resulting from human activities or natural processes, poses a significant and widespread challenge. L-glutamic (L-glu) and L-aspartic acid (L-asp) treatments have been reported to improve plant metabolism of heavy metal-exposed plants, but the role of these amino acids in the resistance to lead (Pb²⁺), cadmium (Cd²⁺), arsenic (As³⁺) and nickel (Ni²⁺) treated-bean are unclear when applied together. This study investigated the L-glu and L-asp supplementation-induced changes in some physio-biochemical parameters and some stress-related gene expression levels in Pb²⁺, Cd²⁺, As³⁺, and Ni²⁺-stressed Phaseolus vulgaris (Elkoca and Gina) grown in nutrient solution. The combination of… More >

YI LI¹, TIANYI WANG¹, HAORAN DING¹, SHIYONG ZHUANG¹, XIAOBO DAI¹, BING YAN^1,2,*

Oncology Research, Vol.32, No.10, pp. 1623-1635, 2024, DOI:10.32604/or.2024.048191 - 18 September 2024

Abstract Background: Oral cancer, a malignancy that is prevalent worldwide, is often diagnosed at an advanced stage. MicroRNAs (miRNAs) in circulating exosomes have emerged as promising cancer biomarkers. The role of miRNA let-7c-5p in oral cancer remains underexplored, and its potential involvement in tumorigenesis warrants comprehensive investigation. Methods: Serum samples from 30 patients with oral cancer and 20 healthy controls were used to isolate exosomes and quantify their RNA content. Isolation of the exosomes was confirmed through transmission electron microscopy. Quantitative PCR was used to assess the miRNA profiles. The effects of let-7c-5p and TAGLN overexpression… More >

CHUN-HUA WANG^1,2, LU-KAI WANG³, RONG-YAUN SHYU⁴, FU-MING TSAI^5,*

BIOCELL, Vol.48, No.9, pp. 1285-1297, 2024, DOI:10.32604/biocell.2024.053746 - 04 September 2024

Abstract Tazarotene-induced gene 1 (TIG1) is induced by a derivative of vitamin A and is known to regulate many important biological processes and control the development of cancer. TIG1 is widely expressed in various tissues; yet in many cancer tissues, it is not expressed because of the methylation of its promoter. Additionally, the expression of TIG1 in cancer cells inhibits their growth and invasion, suggesting that TIG1 acts as a tumor suppressor gene. However, in some cancers, poor prognosis is associated with TIG1 expression, indicating its protumor growth characteristics, especially in promoting the invasion of inflammatory breast cancer More >

Abdul Karim Amin¹, Yan He¹, Xianglong Wang¹, Pengwei Li¹, Muhammad Ahmad Hassan², Mohammad Yousof Soltani³, Yiling Zhang¹, Mohammad Alem Amin⁴, Ahmad Shah Ahmadzai⁵, Yajing Liu^1,3,*, Songhu Wang^1,3,*

Phyton-International Journal of Experimental Botany, Vol.93, No.8, pp. 2075-2093, 2024, DOI:10.32604/phyton.2024.054641 - 30 August 2024

Abstract Tomato (Solanum lycopersicum) is a perishable fruit because of its fast water loss and susceptibility to pathogens in the post-harvest stage, which leads to huge economic losses every year. In this study, firstly from 19 tomato cultivars, we screened out two cultivars, Riogrand and SalarF1, having long and short shelf-life spans, respectively. Secondly, shelf-life analysis was carried out for both cultivars at room temperature. Results exhibited that Riogrand showed higher firmness and less weight loss than SalarF1. The ethylene production was higher in SalarF1, compared with Riogrand during post-harvest storages. We performed transcriptomic analysis of both… More >

Lijun Zhang, Ying Liu^*, Yushou Ma^*, Xinyou Wang

Phyton-International Journal of Experimental Botany, Vol.93, No.8, pp. 1913-1941, 2024, DOI:10.32604/phyton.2024.052621 - 30 August 2024

Abstract Perennial grasses have developed intricate mechanisms to adapt to diverse environments, enabling their resistance to various biotic and abiotic stressors. These mechanisms arise from strong natural selection that contributes to enhancing the adaptation of forage plants to various stress conditions. Methods such as antisense RNA technology, CRISPR/Cas9 screening, virus-induced gene silencing, and transgenic technology, are commonly utilized for investigating the stress response functionalities of grass genes in both warm-season and cool-season varieties. This review focuses on the functional identification of stress-resistance genes and regulatory elements in grasses. It synthesizes recent studies on mining functional genes, regulatory More >