Chunya Hu, Yu He*
Oncologie, Vol.23, No.2, pp. 241-250, 2021, DOI:10.32604/Oncologie.2021.015828
- 22 June 2021
Abstract Objective: The aim of the present study was to investigate the anti-tumor effects of formononetin on human nonsmall cell lung cancer (NSCLC) and its potential molecular mechanism. Methods: A549 cells were treated with
different concentrations of formononetin, then detected the cell proliferation, apoptosis and the expression of
HIPK2 respectively by MTT assay, flow cytometry analysis and RT-qPCR. Then the interaction between miR-
27a-3p and its target gene HIPK2 was verified through luciferase reporter assay. The expression of miR-27a-
3p, HIPK2, and p53 was detected after being treated with different formononetin concentrations by RT-qPCR
and western blot. Results: More >
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