Peng Jing¹, Xiaolong Wang¹, Shigeho Noda², Xiaobo Gong^1,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 36-37, 2019, DOI:10.32604/mcb.2019.07111

Abstract The motion of circulating tumor cells (CTCs) in microcirculatory system is one of the critical steps during cancer metastasis. The moving behavior and stress distribution of circulating tumor cells under different geometry and flow conditions are important basis for studying the adhesion between circulating tumor cells and vessel walls. In the present work, the motion and deformation of circulating tumor cells in capillary tubes are numerically studied using the immersed boundary method (IBM). The membrane stress distribution of CTCs in confined tubes are investigated with under vessel diameters, hematocrit (Ht) values and capillary numbers (Ca). More >

Y. Gan¹, Z. Chen^2,3, S. Montgomery-Smith⁴

CMES-Computer Modeling in Engineering & Sciences, Vol.73, No.1, pp. 45-76, 2011, DOI:10.3970/cmes.2011.073.045

Abstract The material point method (MPM), which is an extension from computational fluid dynamics (CFD) to computational solid dynamics (CSD), is improved for the coupled CFD and CSD simulation of the zona failure response in piezo-assisted intracytoplasmic sperm injection (piezo-ICSI). To evaluate the stresses at any zona material point, a plane stress assumption is made in the local tangent plane of the membrane point, and a simple procedure is proposed to find the effective point connectivity for the orientation of the local tangent plane. With an iterative algorithm in each time step, the original MPM is More >