KUN FENG^1,#, HAO PENG^2,#, QINGPENG LV¹, YEWEI ZHANG^1,*

Oncology Research, Vol.32, No.6, pp. 1063-1078, 2024, DOI:10.32604/or.2024.047078

Abstract Hepatocellular carcinoma (HCC) is a malignancy known for its unfavorable prognosis. The dysregulation of the tumor microenvironment (TME) can affect the sensitivity to immunotherapy or chemotherapy, leading to treatment failure. The elucidation of PHLDA2’s involvement in HCC is imperative, and the clinical value of PHLDA2 is also underestimated. Here, bioinformatics analysis was performed in multiple cohorts to explore the phenotype and mechanism through which PHLDA2 may affect the progression of HCC. Then, the expression and function of PHLDA2 were examined via the qRT-PCR, Western Blot, and MTT assays. Our findings indicate a substantial upregulation of… More >

VRINDA GOEL¹, RUCHIKA TANWAR¹, AJOY KUMAR SAIKIA², UTTAM KUMAR MANDAL^1,*

Journal of Polymer Materials, Vol.39, No.3-4, pp. 283-305, 2022, DOI:10.32381/JPM.2022.39.3-4.8

Abstract The commercially available Polysulfone (PSF) membrane surface was modified by solution polymerization of aniline using different oxidation catalysts i.e., FeCl₃, CuCl₂, and APS. Modified membranes were then characterized with respect to physio-chemical properties like surface chemistry, porosity, wettability, surface roughness, morphology, etc. It was observed that the hydrophilicity/ wettability of membranes was increased upon surface modification by polyaniline which again depended on the nature of the oxidation catalyst used. Membranes developed using FeCl₃ and CuCl₂ as oxidants exhibit improved permeation, protein rejection, and antifouling properties, whereas decrement was observed in modified membrane performance using APS as an More >

NIKITA GUPTA, SARITA KALLA, Z.V.P. MURTHY^*

Journal of Polymer Materials, Vol.40, No.3-4, pp. 317-328, 2023, DOI:10.32381/JPM.2023.40.3-4.12

Abstract Tetramethylurea (TMU) is a good solvent for organic substances and has received little attention as compared to other solvents. The TMU is a polar solution and is one of the molecules with an amphiphilic character. In the present work, an attempt has been made to use TMU as an additive in the preparation of nanofiltration membranes to improve the hydrophilicity of the membrane. The polysulfone membrane has been modified by incorporating different concentrations of TMU (0, 0.5, and 1 wt.%) in order to check the rejection of atrazine in water. This study aim is to More >

V. S. MAMTANI, A. K. GHOSH^*, R. C. BINDAL

Journal of Polymer Materials, Vol.39, No.1-2, pp. 137-149, 2022, DOI:10.32381/JPM.2022.39.1-2.9

Abstract In this study, polysulfone based capillary ultrafiltration membranes with desired characteristics were indigenously developed and their performance was evaluated with respect to turbidity removal from raw sea water. Capillary membranes were spun with in-house fabricated spinneret using polymer casting solution (dope solution) of different compositions having different viscosity using polyvinyl pyrrolidone (PVP) as pore-forming agent. Different experimental conditions namely dope pressure, bore fluid flow rate and air gap distance are optimized to get membranes of desired properties. Test results of individual capillaries in terms of pure water permeability (PWP), separation of single uncharged solutes like… More >

XIAOFENG GAO^1,2,3,4, JUANJUAN GE³, XUZHENG GAO^1,3, NA MEI^1,3, YANTING SU³, SHIGANG SHAN³, WENBIN QIAN³, JIANGHENG GUAN⁵, ZHENWANG ZHANG^1,3,*, LONG WANG^2,3,4,*

Oncology Research, Vol.32, No.4, pp. 659-678, 2024, DOI:10.32604/or.2023.046712

Abstract Background: IQGAP3 plays a crucial role in regulating cell proliferation, division, and cytoskeletal organization. Abnormal expression of IQGAP3 has been linked to various tumors, but its function in glioma is not well understood. Methods: Various methods, including genetic differential analysis, single-cell analysis, ROC curve analysis, Cox regression, Kaplan-Meier analysis, and enrichment analysis, were employed to analyze the expression patterns, diagnostic potential, prognostic implications, and biological processes involving IQGAP3 in normal and tumor tissues. The impact of IQGAP3 on immune infiltration and the immune microenvironment in gliomas was evaluated using immunofluorescence. Additionally, the cBioPortal database was used… More > Graphic Abstract

QIOU GU¹, CHUILIN LAI¹, XIAO GUAN¹, JING ZHU², TIAN ZHAN¹, JIANPING ZHANG^1,*

BIOCELL, Vol.48, No.2, pp. 253-269, 2024, DOI:10.32604/biocell.2023.028336

Abstract Objectives: Colorectal cancer (CRC) is a serious threat to human health worldwide. Oxaliplatin is a platinum analog and is widely used to treat CRC. However, resistance to oxaliplatin restricts its effectiveness and application while its target recognition and mechanism of action also remain unclear. Therefore, we aimed to develop an oxaliplatin-resistant prognostic model to clarify these aspects. Methods: We first obtained oxaliplatin-resistant and parental cell lines, and identified oxaliplatin-resistant genes using RNA sequencing (RNA-seq) and differential gene analysis. We then acquired relevant data from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases.… More > Graphic Abstract

QI XIA¹, XING CHEN², QINGHUA MA³, XIANXIU WEN^2,*

BIOCELL, Vol.48, No.2, pp. 217-228, 2024, DOI:10.32604/biocell.2023.027414

Abstract Background: Breast cancer (BC) is the most common cancer and the leading cause of cancer death in women. Immune features play an important role in improving the prognosis prediction of BC. However, while previous immune signatures consisted mainly of immune genes, immune cell-based signatures have been rarely reported. Methods: In this study, we report that a novel immune cell signature is effective in improving prognostic prediction by combining M2 macrophages. We identified 17 differentially infiltrating immune cells between cancer and normal groups. Prognostic features of the four immune cells identified by LASSO COX analysis showed… More >

JIECHUAN QIU¹, TIANMIN YANG¹, YANNING SUN², KAI SUN², YINGKUN XU³, QINGHUA XIA^1,*

Oncology Research, Vol.32, No.3, pp. 545-561, 2024, DOI:10.32604/or.2023.030462

Abstract This research aims to identify the key fatty acid beta-oxidation (FAO) genes that are altered in kidney renal clear cell carcinoma (KIRC) and to analyze the role of these genes in KIRC. The Gene Expression Omnibus (GEO) and FAO datasets were used to identify these key genes. Wilcoxon rank sum test was used to assess the levels of acyl-CoA dehydrogenase medium chain (ACADM) between KIRC and non-cancer samples. The logistic regression and Wilcoxon rank sum test were used to explore the association between ACADM and clinical features. The diagnostic performance of ACADM for KIRC was… More >

Yuxuan Ying¹, Wei Huang^1,*, Yu-E Ma¹, Fan Peng¹

The International Conference on Computational & Experimental Engineering and Sciences, Vol.27, No.4, pp. 1-3, 2023, DOI:10.32604/icces.2023.010572

Abstract Intensive dynamic loadings are the main threats to the structural damage of protective structures and inner equipment, which has attracted a lot of attention in the field of advance impulsive resistance. Nanofluidic liquid foam (NLF) has become a novel and efficient energy absorption system due to its reusable energy absorption, ultra-high load transfer, and high energy absorption ratio. In order to solve the current problem that the energy absorption mechanism of NLF is still unclear, this paper conducted a systematic experimental study on the dynamic compression and energy absorption behaviours of NLF. The quasi-static cyclic… More >

Haiqi Feng¹, Wei Huang^1,*

The International Conference on Computational & Experimental Engineering and Sciences, Vol.27, No.3, pp. 1-2, 2023, DOI:10.32604/icces.2023.09347

Abstract Intensive dynamic loadings are the main threats to the structural damage of protective structures and inner equipment, which has attracted a lot of attention in the field of advance impulsive resistance. Nanofluidic liquid foam (NLF) has become a novel and efficient energy absorption system due to its reusable energy absorption, ultra-high load transfer, and high energy absorption ratio [1-7]. In order to solve the current problem that the energy absorption mechanism of NLF is still unclear, this paper conducted a systematic experimental study on the dynamic compression and energy absorption behaviours of NLF. The quasi-static… More >