CHAOQUN WANG¹, TING ZHANG², CHAOHE ZHANG^3,*

Oncology Research, Vol.32, No.12, pp. 1867-1879, 2024, DOI:10.32604/or.2024.044547 - 13 November 2024

Abstract Background: Drug resistance is the main factor contributing to cancer recurrence and poor prognosis. Exploration of drug resistance-related mechanisms and effective therapeutic targets are the aim of molecular targeted therapy. In our study, the role of long non-coding RNA (lncRNA) AFAP1-AS1 in gemcitabine resistance and related mechanisms were explored in cervical cancer cells. Methods: Gemcitabine-resistant cervical cancer cell lines HT-3-Gem and SW756-Gem were constructed using the gemcitabine concentration gradient method. The overall survival rates and recurrence-free survival rates were evaluated by Kaplan-Meier analysis. The interaction was verified through a Dual-luciferase reporter gene assay and a… More > Graphic Abstract

Cheng Hou¹, Xiaochao Jin², Xueling Fan^2,*

The International Conference on Computational & Experimental Engineering and Sciences, Vol.30, No.4, pp. 1-1, 2024, DOI:10.32604/icces.2024.012325

Abstract The over-deterministic method (ODM) is dedicated to calculate a small set of unknown coefficients from a large system of equations, by making use of a large number of data points. A displacement over-deterministic method (DODM) developed by Ayatollahi et al. [1] has been employed by for calculating the stress intensity factors (SIFs) as well as the coefficients of the higher-order terms in the Williams’ series expansions for cracked bodies. The ODM provides a great idea to easily obtain fracture parameters, combine with finite element method (FEM).
In our work, a stress over-deterministic method (SODM) has been… More >

Lixiang Wang¹, Longfei Wen^2,3, Rong Tian^2,3,*, Chun Feng^1,4,*

The International Conference on Computational & Experimental Engineering and Sciences, Vol.30, No.3, pp. 1-2, 2024, DOI:10.32604/icces.2024.011137

Abstract The extended finite element method (XFEM) has been successful in crack analysis but faces challenges in modeling multiple cracks. One challenge is the linear dependence and ill-conditioning of the global stiffness matrix, while another is the geometric description for multiple cracks. To address the first challenge, the Improved XFEM (IXFEM) [1–9] is extended to handle multiple crack problems, effectively eliminating issues of linear dependence and ill-conditioning. Additionally, to overcome the second challenge, a novel level set templated cover cutting method (LSTCCM) [10] is proposed, which combines the advantages of the level set method and cover More >

Yanhuan Lin^1,#, Jiaxin Feng^2,#, Hao Fang², Wei Huang², Kanglie Guo², Xiyan Liu², Shuqi Wang², Xiaojuan Liu^2,*

Phyton-International Journal of Experimental Botany, Vol.93, No.10, pp. 2583-2596, 2024, DOI:10.32604/phyton.2024.055616 - 30 October 2024

Abstract Heat shock transcription factor (HSF) are essential regulators of heat shock protein (HSP) gene expression in plants and algae, contributing to their resilience against biotic and abiotic stresses. However, the localization, structure, phylogenetic relationship, and characteristics of PtHSF genes in microalgae, especially in diatom Phaeodactylum tricornutum, remain largely unexplored. This study presents a comprehensive analysis of the PtHSF gene family in P. tricornutum. A genome-wide analysis identified 68 PtHSF genes, which were classified into two distinct subfamilies: traditional and untraditional. Motif and structure analyses revealed evidence of multiple duplication events within the PtHSF gene family. Expression profiling revealed diurnal… More >

Fan Yang^1,2,*, Honggang Mi^1,2, Jian Wu^1,2, Qi Yang^1,2

FDMP-Fluid Dynamics & Materials Processing, Vol.20, No.11, pp. 2637-2656, 2024, DOI:10.32604/fdmp.2024.048574 - 28 October 2024

Abstract The gas production of deep coalbed methane wells in Linxing-Shenfu block decreases rapidly, the water output is high, the supporting effect is poor, the effective supporting fracture size is limited, and the migration mechanism of proppant in deep coal reservoir is not clear at present. To investigate the migration behavior of proppants in complex fractures during the volume reconstruction of deep coal and rock reservoirs, an optimization test on the conductivity of low-density proppants and simulations of proppant migration in complex fractures of deep coal reservoirs were conducted. The study systematically analyzed the impact of… More >

JINXIA CHEN^1,2,3,#, SULI DAI^1,2,#, GENG ZHANG^4,5, SISI WEI^1,2, XUETAO ZHAO³, YANG ZHENG^1,2, YAOJIE WANG^1,2, XIAOHAN WANG^1,2, YUNJIANG LIU^4,5,*, LIANMEI ZHAO^1,2,*

Oncology Research, Vol.32, No.11, pp. 1791-1802, 2024, DOI:10.32604/or.2024.049348 - 16 October 2024

Abstract Background: Triple-negative breast cancer (TNBC) is a heterogeneous, recurring cancer characterized by a high rate of metastasis, poor prognosis, and lack of efficient therapies. KBU2046, a small molecule inhibitor, can inhibit cell motility in malignant tumors, including breast cancer. However, the specific targets and the corresponding mechanism of its function remain unclear. Methods: In this study, we employed (3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H tetrazolium) (MTS) assay and transwell assay to investigate the impact of KBU2046 on the proliferation and migration of TNBC cells in vitro. RNA-Seq was used to explore the targets of KBU2046 that inhibit the motility of TNBC.… More > Graphic Abstract

Qianqian Zhang¹, Yingmei Li^1,*, Jianjun Zhan^2,*, Shan Chen¹

CMC-Computers, Materials & Continua, Vol.81, No.1, pp. 1251-1273, 2024, DOI:10.32604/cmc.2024.053892 - 15 October 2024

Abstract This research focuses on improving the Harris’ Hawks Optimization algorithm (HHO) by tackling several of its shortcomings, including insufficient population diversity, an imbalance in exploration vs. exploitation, and a lack of thorough exploitation depth. To tackle these shortcomings, it proposes enhancements from three distinct perspectives: an initialization technique for populations grounded in opposition-based learning, a strategy for updating escape energy factors to improve the equilibrium between exploitation and exploration, and a comprehensive exploitation approach that utilizes variable neighborhood search along with mutation operators. The effectiveness of the Improved Harris Hawks Optimization algorithm (IHHO) is assessed by… More >

Yangjian Si^1,2, Yujie Wei^1,2,*

The International Conference on Computational & Experimental Engineering and Sciences, Vol.29, No.1, pp. 1-1, 2024, DOI:10.32604/icces.2024.011974

Abstract Edge cracking represents one of the most prominent damage modes in engineering practice and hence receives immense attention from academic societies. When branched cracks or multiple cracks are present at the edge, their propagation may be affected by the interaction between the cracks. In this talk, we may cover the elasticity of a cracked half-plane with two typical scenarios: a double branched crack with two rays emanating from one point on the edge and two edge cracks spaced by a certain distance (Kalthoff–Winkler cracks). By adopting the combination of the Schwartz-Christoffel conformal mapping and the… More >

Jun Yuan¹, Rongpeng Liu⁴, Xiaoyun Wang^3,*, Haihui Fu^2,*

Phyton-International Journal of Experimental Botany, Vol.93, No.9, pp. 2267-2284, 2024, DOI:10.32604/phyton.2024.055338 - 30 September 2024

Abstract Cadmium (Cd) has seriously affected the quality of traditional Chinese medicinal material Salvia miltiorrhiza in recent years, threatening human health. The physiological and metabolic profiles of S. miltiorrhiza in response to Cd stress have been revealed in previous studies. However, transcriptional and post-transcriptional regulation in response to different degrees of Cd (0, 25, 50, and 100 mg/kg) stress in S. miltiorrhiza remains unclear. Here, transcriptome atlas in S. miltiorrhiza under different degrees of Cd Stress was unveiled using RNA sequencing (RNA-seq). These results showed that the profiles of gene expression were different in the response to Cd treatment. Defense More >

HEYI LIU^1,#, WENHAO CHENG^2,#, JINGLIANG HE², LUYAO ZHANG², KADIRYA ASAN², YULU CHEN², JIAYUN WANG², QI GAO², SENG WANG², ZIEN YU², SHAOJIE MA², LAN ZHU^3,*, JING JI^2,3,*

BIOCELL, Vol.48, No.10, pp. 1465-1473, 2024, DOI:10.32604/biocell.2024.052670 - 02 October 2024

Abstract Background: Osteosarcoma is the most common primary bone malignancy, with a strong tendency towards local invasion and metastasis. The SRY-Box Transcription Factor 1 (SOX1) gene, a member of the HMG-box family of DNA-binding transcription factors, plays a crucial role in embryogenesis and tumorigenesis. However, its role in osteosarcoma, particularly in relation to metastatic potential, is not well understood. Methods: The GSE14359 dataset containing five samples of conventional osteosarcoma and four samples of lung metastatic osteosarcoma was obtained from the Gene Expression Omnibus (GEO) database and analyzed for differential gene expression using the R language. Gene… More >