ZHILI ZHUO^#, DONGNI ZHANG^#, WENPING LU^*, XIAOQING WU, YONGJIA CUI, WEIXUAN ZHANG, MENGFAN ZHANG

Oncology Research, Vol.32, No.6, pp. 1093-1107, 2024, DOI:10.32604/or.2024.047257 - 23 May 2024

Abstract Breast cancer is the leading cause of cancer-related deaths in women worldwide, with Hormone Receptor (HR)+ being the predominant subtype. Tamoxifen (TAM) serves as the primary treatment for HR+ breast cancer. However, drug resistance often leads to recurrence, underscoring the need to develop new therapies to enhance patient quality of life and reduce recurrence rates. Artemisinin (ART) has demonstrated efficacy in inhibiting the growth of drug-resistant cells, positioning art as a viable option for counteracting endocrine resistance. This study explored the interaction between artemisinin and tamoxifen through a combined approach of bioinformatics analysis and experimental… More > Graphic Abstract

JIAN TANG¹, CHENQIANG ZHU¹, YUN CHEN¹, YUNLONG WU¹, MING HE¹, YI ZHOU², MINGHUA XIE^2,*

BIOCELL, Vol.48, No.4, pp. 639-651, 2024, DOI:10.32604/biocell.2024.047562 - 09 April 2024

Abstract Background: The specific impact of sphingolipid metabolism on developing hepatocellular Carcinoma (HCC) remains unclear. This study aims to explore the relationship between sphingolipid metabolism and HCC prognosis, immune response, and drug sensitivity. Methods: Data were obtained from The Cancer Genome Atlas (TCGA)-Hepatocellular Carcinoma (LIHC) and Gene Expression Omnibus (GEO, GSE14520 datasets). 47 sphingolipid metabolism genes were obtained from the Kyoto Encyclopedia of Genes and Genomes (KEGG) database. After classifying HCC samples using the Non-negative Matrix Factorization (NMF) clustering method, differentially expressed genes were screened. Then, 8 risk genes were obtained by univariate analysis, survival random forest… More > Graphic Abstract

YANAN MA¹, SHANSHAN WANG^2,*, HUIGUO DING^1,*

BIOCELL, Vol.48, No.3, pp. 463-471, 2024, DOI:10.32604/biocell.2024.048244 - 15 March 2024

Abstract Background: Hepatocellular carcinoma (HCC) is a common malignant tumor with poor prognosis and high mortality worldwide. Although cystathionine-gamma-lyase (CSE) plays an important role in the development of multiple tumors, the clinical implication and potential mechanisms of CSE in HCC development remain elusive. Methods: In our study, the CSE expression in HCC was analyzed in Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) datasets and further confirmed by RT-qPCR and immunohistochemistry assays in HCC samples. Furthermore, the associations between CSE expression and HCC malignancy as well as survival were analyzed in GSE14520 and validated… More >

LIN QIU^1,#, ANQI TAO^1,#, XIAOQIAN SUN^4,5, FEI LIU¹, XIANPENG GE^2,3,*, CUIYING LI^1,*

Oncology Research, Vol.31, No.5, pp. 715-752, 2023, DOI:10.32604/or.2023.029443 - 21 July 2023

Abstract We analyzed RNA-sequencing (RNA-seq) and clinical data from head and neck squamous cell carcinoma (HNSCC) patients in The Cancer Genome Atlas (TCGA) Genomic Data Commons (GDC) portal to investigate the prognostic value of anoikis-related genes (ARGs) in HNSCC and develop new targeted drugs. Differentially expressed ARGs were screened using bioinformatics methods; subsequently, a prognostic model including three ARGs (CDKN2A, BIRC5, and PLAU) was constructed. Our results showed that the model-based risk score was a good prognostic indicator, and the potential of the three ARGs in HNSCC prognosis was validated by the TISCH database, the model’s… More >

WEI LIANG^1,2,*, ZONGWEI ZHANG^1,2, KEJU YANG^1,2,3, HONGTU HU^1,2, QIANG LUO^1,2, ANKANG YANG^1,2, LI CHANG⁴, YUANYUAN ZENG⁴

BIOCELL, Vol.47, No.6, pp. 1253-1263, 2023, DOI:10.32604/biocell.2023.027373 - 19 May 2023

Abstract Background: Diabetic nephropathy (DN) is the most common complication of type 2 diabetes mellitus and the main cause of end-stage renal disease worldwide. Diagnostic biomarkers may allow early diagnosis and treatment of DN to reduce the prevalence and delay the development of DN. Kidney biopsy is the gold standard for diagnosing DN; however, its invasive character is its primary limitation. The machine learning approach provides a non-invasive and specific criterion for diagnosing DN, although traditional machine learning algorithms need to be improved to enhance diagnostic performance. Methods: We applied high-throughput RNA sequencing to obtain the genes… More >

Zongying Fu¹, Yongdong Zhou¹, Tingguo Yan², Yun Lu^1,*

Journal of Renewable Materials, Vol.11, No.1, pp. 93-102, 2023, DOI:10.32604/jrm.2023.021808 - 10 August 2022

Abstract Drying crack is a common phenomenon occurring during moisture discharge from wood, reducing efficient wood utilization. Drying crack is primarily caused by drying stress, and the reasonable methods for determining drying stress are sparse. In this study, the initiation and propagation of cracks during wood discs drying were simulated using the extended finite element method (XFEM). The distribution of drying stress and displacement was analyzed at different crack conditions based on the simulation results. This study aimed to solve the problem of the limitation of drying stress testing methods and provide a new idea for More >

Salah K. Elsayed^1,*, Ahmed M. Agwa^2,3, Mahmoud A. El-Dabbah², Ehab E. Elattar¹

Intelligent Automation & Soft Computing, Vol.28, No.3, pp. 639-651, 2021, DOI:10.32604/iasc.2021.016464 - 20 April 2021

Abstract The problem of parameters identification for transformer equivalent circuit can be solved by optimizing a nonlinear formula. The objective function attempts to minimize the sum of squared relative errors amongst the accompanying calculated and actual points of currents, powers, and secondary voltage during the load test of the transformer subject to a set of parameters constraints. The authors of this paper propose applying a new and efficient stochastic optimizer called the slime mold optimization algorithm (SMOA) to identify parameters of the transformer equivalent circuit. The experimental measurements of load test of single- and three-phase transformers… More >

P. Pesante¹, K. Saavedra^2,*, G. Pincheira²

CMC-Computers, Materials & Continua, Vol.67, No.3, pp. 4061-4079, 2021, DOI:10.32604/cmc.2021.015268 - 01 March 2021

Abstract This work proposes to study the effective elastic properties (EEP) of a wood-plastic composite (WPC) made from polyethylene terephthalate (PET) and Chilean Radiate pine’s wood flour, using finite element simulations of a representative volume element (RVE) with periodic boundary conditions. Simulations are validated through a static 3-point bending test, with specimens obtained by extruding and injection. The effect of different weight fractions, space orientations and sizes of particles are here examined. Numerical predictions are empirically confirmed in the sense that composites with more wood flour content and bigger size, have higher elastic modulus. However, these More >

Patrick C. Doherty, Heather E. Dillon^† , Justin Roberts

Frontiers in Heat and Mass Transfer, Vol.9, pp. 1-6, 2017, DOI:10.5098/hmt.9.1

Abstract The onset of turbulence in natural convection systems is difficult to predict using traditional computational techniques. The flow patterns that occur before and after the onset of turbulence may be better understood with the help of visual techniques like Schlieren imaging. Schlieren imaging allows visualization of the density gradients of a fluid using collimated light and refractive properties. In this experiment, a device was designed to test the behavior of airflow with non-isothermal boundary conditions within a rectangular cavity. Previous computational fluid modeling suggested a period doubling route to chaos in a cavity with a… More >

Biswajit De^*, Rajsekhar Panua

Frontiers in Heat and Mass Transfer, Vol.6, pp. 1-6, 2015, DOI:10.5098/hmt.6.11

Abstract An incorporated arithmetical model has been urbanized and investigated for CFD replication of a solitary cylinder, four stroke, straight inoculation, compressed ignition diesel engine of 3.5 kW for in-cylinder combustion analysis and authenticated under engine simulations at full load functioning conditions with foundation fuel diesel and 10% JME (volume basis) blend with diesel at invariable speed of 1500 rpm. For advancing the exactness of the exertion, a number of sub models, such as species transport model explaining the actual biodiesel energy content and molecular structure as soon as fuel blend is initiated, spray break-up model, More >