XIANG LI^1,#, WENKE JIN^2,#, LIFENG WU², HUAN WANG¹, XIN XIE¹, WEI HUANG^1,*, BO LIU^2,*

Oncology Research, Vol.33, No.1, pp. 67-81, 2025, DOI:10.32604/or.2024.055921 - 20 December 2024

Abstract Background: Triple-negative breast cancer (TNBC), characterized by its lack of traditional hormone receptors and HER2, presents a significant challenge in oncology due to its poor response to conventional therapies. Autophagy is an important process for maintaining cellular homeostasis, and there are currently autophagy biomarkers that play an effective role in the clinical treatment of tumors. In contrast to targeting protein activity, intervention with protein-protein interaction (PPI) can avoid unrelated crosstalk and regulate the autophagy process with minimal interference pathways. Methods: Here, we employed Naive Bayes, Decision Tree, and k-Nearest Neighbors to elucidate the complex PPI… More >

Zhao-Jun Zhang¹, Wen-Wei Wang^1,2,*, Jing-Shui Zhen¹, Bo-Cheng Li¹, De-Cheng Cai¹, Yang-Yang Du¹, Hui Huang²

Structural Durability & Health Monitoring, Vol.19, No.1, pp. 105-123, 2025, DOI:10.32604/sdhm.2024.052506 - 15 November 2024

Abstract This study aimed to investigate the moment redistribution in continuous glass fiber reinforced polymer (GFRP)-concrete composite slabs caused by concrete cracking and steel bar yielding in the negative bending moment zone. An experimental bending moment redistribution test was conducted on continuous GFRP-concrete composite slabs, and a calculation method based on the conjugate beam method was proposed. The composite slabs were formed by combining GFRP profiles with a concrete layer and supported on steel beams to create two-span continuous composite slab specimens. Two methods, epoxy resin bonding, and stud connection, were used to connect the composite… More >

Kithmini Godewatte Arachchige¹, Mohsin Murtaza², Chi-Tsun Cheng², Bader M. Albahlal^3,*, Cheng-Chi Lee^4,5,*

CMC-Computers, Materials & Continua, Vol.81, No.3, pp. 3679-3705, 2024, DOI:10.32604/cmc.2024.059378 - 19 December 2024

Abstract Information security has emerged as a crucial consideration over the past decade due to escalating cyber security threats, with Internet of Things (IoT) security gaining particular attention due to its role in data communication across various industries. However, IoT devices, typically low-powered, are susceptible to cyber threats. Conversely, blockchain has emerged as a robust solution to secure these devices due to its decentralised nature. Nevertheless, the fusion of blockchain and IoT technologies is challenging due to performance bottlenecks, network scalability limitations, and blockchain-specific security vulnerabilities. Blockchain, on the other hand, is a recently emerged information… More >

Xin Qi^1,2, Xingtao Shi¹, Yingwen Liu^1,*

Frontiers in Heat and Mass Transfer, Vol.22, No.6, pp. 1661-1678, 2024, DOI:10.32604/fhmt.2024.058959 - 19 December 2024

Abstract After optimizing the compressor design, condenser tube diameter, and tube row arrangement, air supply volumetric flow rate, and refrigerant charge of the domestic dehumidifier. The optimized design schemes were obtained from the original combinations by non-dominated sorting, and the optimized design schemes were experimentally verified under three environmental conditions according to the test method of T/CAS 342-2020 to obtain a complete idea of dehumidifier multi-component improvement. The results show that the dehumidifying capacity of Scheme 5 is slightly increased by 2.5% at 27°C/60% RH, and its energy factor is significantly increased by 24.6%. When the… More >

Miao Huang¹, Maedeh Lotfi¹, Heyang Wang⁴, Hayley Sussman⁵, Kevin Connell¹, Quang Vo¹, Malisa Sarntinoranont¹, Hitomi Yamaguchi¹, Juan Guan², Xin Tang^1,3,*

The International Conference on Computational & Experimental Engineering and Sciences, Vol.32, No.1, pp. 1-2, 2024, DOI:10.32604/icces.2024.011130

Abstract Mechanotransduction, i.e., living cells sense and transduce mechanical forces into intracellular biochemical signaling and gene expression, is ubiquitous across diverse organisms. Increasing evidence suggests that mechanotransduction significantly influences cell functions and its mis-regulation is at the heart of various pathologies. A quantitative characterization of the relationship between mechanical forces and resulted mechanotransduction is pivotal in understanding the rules of life and innovating new therapeutic strategies [1-3]. However, while such relationship on the cell surface membrane and cytoskeleton have been well studied, little is known about whether/how mechanical forces applied on the cell interior nucleus (“headquarter… More >

Yuan Xu^1,*, Govind Gour², Manuela Galati³, Abdollah Saboori³, Antonio Pellegrino⁴

The International Conference on Computational & Experimental Engineering and Sciences, Vol.31, No.2, pp. 1-1, 2024, DOI:10.32604/icces.2024.013220

Abstract The dynamic behaviour of Ti-6Al-2Sn-4Zr-2Mo additively manufactured by electron beam melting (EBM) is presented in this study considering synchronised tension-torsion loading. A bespoke spilt Hopkinson Tension-Torsion bar is used to generate combined tensile and torsional stress pulses that interact simultaneously with a novel specimen geometry. High-speed digital imaging correlation techniques are employed to assess the high-rate deformation and crack propagation of the specimen. The material's dynamic response was analysed across a spectrum of stress states, including uniaxial tension, shear, and combinations of tension and shear at strain rates ranging between 500 s^-1 and 2000 s^-1. Comparable More >

Zhengyuan Pei¹, Yasushi Koito^2,*

Frontiers in Heat and Mass Transfer, Vol.22, No.5, pp. 1381-1397, 2024, DOI:10.32604/fhmt.2024.056624 - 30 October 2024

Abstract Extended experiments were conducted on the oscillation characteristics of merged liquid slugs in a horizontally oriented polymer pulsating heat pipe (PHP). The PHP’s serpentine channel comprised 14 parallel channels with a width of 1.3 and a height of 1.1 . The evaporator and condenser sections were 25 and 50 long, respectively, and the adiabatic section in between was 75 mm long. Using a plastic 3D printer and semi-transparent filament made from acrylonitrile butadiene styrene, the serpentine channel was printed directly onto a thin polycarbonate sheet to form the PHP. The PHP was charged with hydrofluoroether-7100.… More >

Alexei Vjatkin^*, Svyatoslav Petukhov, Victor Kozlov

FDMP-Fluid Dynamics & Materials Processing, Vol.20, No.11, pp. 2475-2488, 2024, DOI:10.32604/fdmp.2024.052377 - 28 October 2024

Abstract A genuine technological issue–the thermal convection of liquid in a rotating cavity–is investigated experimentally. The experiments are conducted within a horizontal annulus with isothermal boundaries. The inner boundary of the annulus has a higher temperature, thus exerting a stabilising influence on the system. It is shown that when the layer rotation velocity diminishes, two-dimensional azimuthally periodic convective rolls, rotating together with the cavity, emerge in a threshold manner. The development of convection is accompanied by a significant intensification of heat transfer through the layer. It is shown that the averaged thermal convection excitation in the… More > Graphic Abstract

Kai Yang^1,2, Qinwen Yao^1,2, Yingshan Li^1,2, Wanchang Chen^1,2, Saleh Khorasani³, Hua Wang^1,2, Qingtai Xiao^1,2,4,*

FDMP-Fluid Dynamics & Materials Processing, Vol.20, No.11, pp. 2585-2602, 2024, DOI:10.32604/fdmp.2024.050704 - 28 October 2024

Abstract Particle suspension and deposition dynamics are significant factors affecting the level of mixing quality in solid-liquid two-phase stirring processes. In general, the ability to increase the suspension rate and minimize deposition effects is instrumental in improving the uniformity of particle mixing, accelerating the reaction of involved solid-liquid two-phase, and improving the efficiency of production operations. In this work, suspension and deposition indicator based on the Betti number and a uniformity indicator are introduced and obtained by means of image analysis. The influence of the blade type, rotation speed, blade diameter and blade bottom height on… More > Graphic Abstract

Martha L. Sánchez^1,*, G. Capote²

Journal of Renewable Materials, Vol.12, No.10, pp. 1791-1810, 2024, DOI:10.32604/jrm.2024.055122 - 23 October 2024

Abstract The construction sector is one of the main sources of pollution, due to high energy consumption and the toxic substances generated during the processing and use of traditional materials. The production of cement, steel, and other conventional materials impacts both ecosystems and human health, increasing the demand for ecological and biodegradable alternatives. In this paper, we analyze the properties of panels made from a combination of plant fibers and castor oil resin, analyzing the viability of their use as construction material. For the research, orthogonal fabrics made with waste plant fibers supplied by a company… More >