SHIQIN JIANG^1,#, YICHUN TANG^2,#, FENG MA³, YUCHUN NIU^4,*, LEI SUN^5,*

Oncology Research, Vol.33, No.1, pp. 213-224, 2025, DOI:10.32604/or.2024.046895 - 20 December 2024

Abstract Objective: Small cell lung cancer (SCLC) is commonly recognized as the most fatal lung cancer type. Despite substantial advances in immune checkpoint blockade therapies for treating solid cancers, their benefits are limited to a minority of patients with SCLC. In the present study, novel indicators for predicting the outcomes and molecular targets for SCLC treatment were elucidated. Methods: We conducted bioinformatics analysis to identify the key genes associated with tumor-infiltrating lymphocytes in SCLC. The functional role of the key gene identified in SCLC was determined both in vitro and in vivo. Results: A significant correlation was observed between… More >

Adel Sabry Eesa^*

Intelligent Automation & Soft Computing, Vol.39, No.4, pp. 697-723, 2024, DOI:10.32604/iasc.2024.053192 - 06 September 2024

Abstract While many metaheuristic optimization algorithms strive to address optimization challenges, they often grapple with the delicate balance between exploration and exploitation, leading to issues such as premature convergence, sensitivity to parameter settings, and difficulty in maintaining population diversity. In response to these challenges, this study introduces the Chase, Pounce, and Escape (CPE) algorithm, drawing inspiration from predator-prey dynamics. Unlike traditional optimization approaches, the CPE algorithm divides the population into two groups, each independently exploring the search space to efficiently navigate complex problem domains and avoid local optima. By incorporating a unique search mechanism that integrates More >

RUI ZHANG^1,2,#, PENG ZHOU^1,3,#, XIA OU⁴, PEIZHU ZHAO², XIJING GUO², MIAN XI^5,*, CHEN QING^1,*

Oncology Research, Vol.31, No.6, pp. 887-897, 2023, DOI:10.32604/or.2023.030184 - 15 September 2023

Abstract Esophageal squamous cell carcinoma (ESCC) is among the most prevalent causes of cancer-related death in patients worldwide. Resistance to immunotherapy and chemotherapy results in worse survival outcomes in ESCC. It is urgent to explore the underlying molecular mechanism of immune evasion and chemoresistance in ESCC. Here, we conducted RNA-sequencing analysis in ten ESCC tissues from cisplatin-based neoadjuvant chemotherapy patients. We found that DMRTA1 was extremely upregulated in the non-pathologic complete response (non-pCR) group. The proliferation rate of esophageal squamous carcinoma cells was markedly decreased after knockdown of DMRTA1 expression, which could increase cisplatin sensitivity in More >

LAURA MARRONE¹, MASSIMO D’AGOSTINO¹, CAROLINA GIORDANO², VALERIA DI GIACOMO¹, SIMONA URZINI¹, CHIARA MALASOMMA¹, MARIA PAOLA GAMMELLA¹, MARTINA TUFANO¹, SIMONA ROMANO^1,*, MARIA FIAMMETTA ROMANO^1,*

Oncology Research, Vol.31, No.4, pp. 423-436, 2023, DOI:10.32604/or.2023.028392 - 25 June 2023

Abstract Scaffold proteins are crucial regulators of signaling networks, and their abnormal expression may favor the development of tumors. Among the scaffold proteins, immunophilin covers a unique role as ‘protein-philin’ (Greek ‘philin’ = friend) that interacts with proteins to guide their proper assembly. The growing list of human syndromes associated with the immunophilin defect underscores the biological relevance of these proteins that are largely opportunistically exploited by cancer cells to support and enable the tumor’s intrinsic properties. Among the members of the immunophilin family, the FKBP5 gene was the only one identified to have a splicing variant. More > Graphic Abstract

R. Mangalagowri^1,*, Revathi Venkataraman²

Intelligent Automation & Soft Computing, Vol.35, No.2, pp. 1565-1580, 2023, DOI:10.32604/iasc.2023.026360 - 19 July 2022

Abstract Cloud computing involves remote server deployments with public network infrastructures that allow clients to access computational resources. Virtual Machines (VMs) are supplied on requests and launched without interactions from service providers. Intruders can target these servers and establish malicious connections on VMs for carrying out attacks on other clustered VMs. The existing system has issues with execution time and false-positive rates. Hence, the overall system performance is degraded considerably. The proposed approach is designed to eliminate Cross-VM side attacks and VM escape and hide the server’s position so that the opponent cannot track the target… More >

Haolong Yang¹, Chunqiang Hu¹, Guwei Li^2,*, Jingchun Fan³

Computer Systems Science and Engineering, Vol.39, No.3, pp. 365-372, 2021, DOI:10.32604/csse.2021.016377 - 12 August 2021

Abstract Despite the support of all kinds of fire prevention measures and high-tech fire prevention equipment, fires still occur frequently because of both anthropogenic factors and natural disasters. This issue has drawn the attention of schools, all levels of government, and other organizations. Many types of organizations carry out fire drills throughout the year. Because this kind of drill cannot anticipate the specific circumstances of each fire, which are generally far more complicated than drills, most people cannot correctly choose the optimal escape route from real fires. Thus, a fire-scene virtual simulation system based on the More >

SAYEQUA DANDOTI^*

BIOCELL, Vol.45, No.4, pp. 863-884, 2021, DOI:10.32604/biocell.2021.013993 - 22 April 2021

Abstract Inactivation of apoptosis is the prime phenomenon in cancer development and cancer treatments. Mutations in the apoptotic pathway not only exert resistance to apoptosis and provide a survival advantage to cancer cells but also confer resistance to cancer therapies. Escaping apoptosis is the “hallmark” of cancer cells. Cancer cells can withstand many apoptotic stimuli, such as DNA damage, unfavorable environments, and cytotoxic therapies. Substantial research has been carried out and is in good progress on the various mechanisms adopted by cancer cells to evade apoptosis. This article reviews the apoptosis escape mechanisms by cancer cells, More >

Li Lei^*, Wukai Chen, Huiling Li, Shuai Shi

FDMP-Fluid Dynamics & Materials Processing, Vol.16, No.5, pp. 837-856, 2020, DOI:10.32604/fdmp.2020.09631 - 09 October 2020

Abstract Urban tunnels are generally narrow and fire smoke can hardly diffuse. In the present study, numerical simulation is used to analyze the diffusion of high temperature smoke produced by fire inside a specific tunnel (the Kaiyuan tunnel). The results are compared with similar data relating to other tests to determine the validity of the numerical method. Moreover, the critical velocity obtained by numerical simulation of 5 MW, 20 MW, and 50 MW fires in curved and linear sections of the considered tunnel is compared with the values obtained using empirical formulas. The results show that,… More >