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  • Open Access

    ARTICLE

    ZMIZ2/MCM3 Axis Participates in Triple-Negative Breast Cancer Progression

    Xiaopan Zou1,2, Meiyang Sun3, Xin Jiang1, Jingze Yu2, Xiaomeng Li4,*, Bingyu Nie1,*

    Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.066662 - 30 December 2025

    Abstract Objective: Triple-negative breast cancer (TNBC) is highly aggressive and lacks an effective targeted therapy. This study aimed to elucidate the functions and possible mechanisms of action of zinc finger miz-type containing 2 (ZMIZ2) and minichromosome maintenance complex component 3 (MCM3) in TNBC progression. Methods: The relationship between ZMIZ2 expression and clinical characteristics of TNBC was investigated. In vitro and in vivo experiments were performed to investigate the role of ZMIZ2 dysregulation in TNBC cell malignant behaviors. The regulatory relationship between ZMIZ2 and MCM3 was also explored. Transcriptome sequencing was performed to elucidate possible mechanisms underlying the ZMIZ2/MCM3… More >

  • Open Access

    ARTICLE

    Comprehensive Network Analysis of the Molecular Regulation Mechanism for Breast Cancer Metastasis

    Shaoguan Huang1, Rong Zhang2, Lizhen Liu3,*

    Oncologie, Vol.23, No.1, pp. 159-171, 2021, DOI:10.32604/Oncologie.2021.012489 - 30 March 2021

    Abstract Breast cancer is one of malignant severe diseases that cause cancer death in women. Although research about the pathogenesis and studies about treatment mechanisms in breast cancer have become clear focuses, we have no clear conclusion yet. Therefore, this research is based on a modular approach to explore key factors and molecular mechanisms that affect breast cancer metastasis. First of all, it is necessary to download breast cancer-related data on the GEO database, and we analyzed the difference between primary tumors and metastatic lesions to obtain differential gene expression profiles. On this basis, a series… More >

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