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    ARTICLE

    An AI-Enabled Framework for Transparency and Interpretability in Cardiovascular Disease Risk Prediction

    Isha Kiran1, Shahzad Ali2,3, Sajawal ur Rehman Khan4,5, Musaed Alhussein6, Sheraz Aslam7,8,*, Khursheed Aurangzeb6,*

    CMC-Computers, Materials & Continua, Vol.82, No.3, pp. 5057-5078, 2025, DOI:10.32604/cmc.2025.058724 - 06 March 2025

    Abstract Cardiovascular disease (CVD) remains a leading global health challenge due to its high mortality rate and the complexity of early diagnosis, driven by risk factors such as hypertension, high cholesterol, and irregular pulse rates. Traditional diagnostic methods often struggle with the nuanced interplay of these risk factors, making early detection difficult. In this research, we propose a novel artificial intelligence-enabled (AI-enabled) framework for CVD risk prediction that integrates machine learning (ML) with eXplainable AI (XAI) to provide both high-accuracy predictions and transparent, interpretable insights. Compared to existing studies that typically focus on either optimizing ML… More >

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