Rohan Suresh Daniel^1,2, Georgia K. Schmidt^1,2, Hayato Nakanishi^1,2, Karen Smayra^1,2, Mariah N. Mascara^1,2, Dilip K. Vankayalapati^1,2, Reem H. Matar^1,2,3, Christian A. Than^1,2,4, George Shiakos⁵, Ioannis Tzanavaros^2,5,*

Congenital Heart Disease, Vol.18, No.2, pp. 245-265, 2023, DOI:10.32604/chd.2023.027596 - 15 March 2023

Abstract Background: Persistent patent ductus arteriosus (pPDA) is a common condition in preterm infants. This meta-analysis aimed to assess the safety and efficacy of transcatheter closure (TC) when compared to surgical ligation (SL) in preterm infants with pPDA. Methods: A literature search of Ovid Cochrane Library, Medline, Embase, Epub, Scopus, PMC Preprints, and was conducted from inception to May 06, 2022. Eligible studies reported infants diagnosed with pPDA born at ≤2000 g birth weight or at ≤37 weeks’ who underwent TC or SL as treatment. This review was registered in PROSPERO (CRD42022325944). Results: From 97 studies screened, 8… More >

Shibin Sun^1,#, Geoffrey J. Changwe^1,2,#, Zeeshan Farhaj¹, Hongxin Li^1,*, Yuekun Sun¹, Zhongzheng Kong¹

Congenital Heart Disease, Vol.17, No.4, pp. 437-445, 2022, DOI:10.32604/chd.2022.019943 - 04 July 2022

Abstract Background: Closure of large patent ductus arteriosus (PDA) in older children has been accomplished using surgical and percutaneous techniques with remarkable outcomes. However, outcomes amongst infants have been variable with several drawbacks. Here we describe a novel minimally invasive technique, a product of mini-thoracotomy and traditional percutaneous technique skills, accomplished exclusively under echocardiography guidance. Methods: Symptomatic infants with a significant left-to-right shunt from PDA measuring more than 4 mm were selected. The symptoms were varying degrees of tachypnea, tachycardia, heart failure, failure to thrive, recurrent respiratory tract infections, or intensive care unit treatment for a longer duration.… More >

Annina Dietrich^1,2, Daniel Quandt^1,2, Oliver Kretschmar^1,2, Walter Knirsch^1,2,*

Congenital Heart Disease, Vol.17, No.2, pp. 215-230, 2022, DOI:10.32604/CHD.2021.017232 - 26 January 2022

Abstract Objectives: To determine immediate and long-term follow-up of transcatheter closure of patent ductus arteriosus (PDA) in children. Background: National antibiotic prophylaxis (AP) guideline for infective endocarditis changed after 2009, the effect on practice of PDA closure is unknown. Methods: Observational single center study analyzing follow-up of PDA closure comparing two time periods before (2002–2009) and after (2010–2019) changes in AP guideline. Results: 332 patients (68.1% female), median (interquartile range) age 3.0 years (1.5–5.7) and body weight 14.0 kg (10.0–19.3), were enrolled. PDA morphology was conical type A (50.3%), window type B (1.2%), tubular type C (40.1%), complex type… More >

Sibao Wang, Silin Pan^*, Gang Luo, Zhixian Ji, Na Liu

Congenital Heart Disease, Vol.17, No.1, pp. 45-60, 2022, DOI:10.32604/CHD.2022.016332 - 26 October 2021

Abstract The aim of this study was to perform a systematic review and meta-analysis to evaluate the safety and efficacy of ductus arteriosus stent (DAS) compared with surgical systemic-pulmonary artery shunt (SPS) in patients with ductal-dependent pulmonary blood flow. A literature search was conducted in PubMed, Embase, and the Cochrane Library databases from their inception to December 2020. Two reviewers independently screened the articles, evaluated the quality of the articles, and collected the data. Meta-analyses were conducted using fixed and random effects models. We used the I-square (I² ) test to examine heterogeneity and the funnel plot… More >

Alessia Callegari¹, Barbara Burkhardt¹, Christa Relly², Walter Knirsch¹, Martin Christmann¹

Congenital Heart Disease, Vol.14, No.4, pp. 671-677, 2019, DOI:10.1111/chd.12830

Abstract Background: Since routine clinical use of antibiotics as well as surgical and catheter‐ based closure of a patent arterial duct (PDA), PDA‐associated infective endarteritis (PDA‐IE) is rare but can still occur when the ductus is still open or as it closes. Thus, clinicians should maintain a high index of concern for patients with unexplained fever.
Methods: We report on a PDA‐IE in a young infant shortly after potentially delayed obliteration of a PDA. We discuss this case report by reviewing the literature in regard to the pathogenesis (infection primary or secondary to PDA thrombus formation), clinical (new… More >

Jesse Lee^1,2, Kanishka Ratnayaka¹, John Moore¹, Howaida El‐Said¹

Congenital Heart Disease, Vol.14, No.5, pp. 791-796, 2019, DOI:10.1111/chd.12786

Abstract Background/Objective: Stenting the ductus arteriosus (DAS) has become an alternative to surgical systemic to pulmonary artery shunts in neonates with ductal‐ dependent pulmonary blood flow (PBF). Femoral approach for a vertical ductus can be difficult secondary to the acute angle and tortuous course, thus alternative ac‐ cess sites have been explored. Carotid access complications have been reported in 5%‐10%. The extensive use of an axillary arterial approach in the United States has not been reported. The aim of this study is to describe our experience with DAS using the axillary approach.
Methods: We reviewed all patients with… More >

Regan E. Giesinger¹, Adrianne R. Bischoff³, Patrick J. McNamara^1,2

Congenital Heart Disease, Vol.14, No.2, pp. 311-316, 2019, DOI:10.1111/chd.12738

Abstract Ligation of a hemodynamically significant ductus arteriosus results in significant changes in loading conditions which have predictable consequences. Postligation cardiac syndrome, defined as hypotension requiring inotropic support and failure of oxygenation and ventilation, may occur 6‐12 hours following ligation due to left ven‐ tricular systolic and diastolic failure, respectively. Afterload is the primary driver of this decompensation. In this review, we describe the pathophysiological changes in loading conditions associated with postligation cardiac syndrome and other contrib‐ utors to cardiovascular dysfunction following ductal ligation. We present strategies for perioperative optimization and a physiology‐based algorithm for postoperative More >

Shyam Sathanandam¹, Stephanie Whiting¹, Jorden Cunningham¹, David Zurakowski², Leah Apalodimas¹, B. Rush Waller¹, Ranjit Philip¹, Athar M. Qureshi³

Congenital Heart Disease, Vol.14, No.1, pp. 6-14, 2019, DOI:10.1111/chd.12729

Abstract Background: Patent ductus arteriosus (PDA) is highly prevalent in extremely low birth weight (ELBW), preterm infants. There are diverse management approaches for the PDA in ELBW infants. The objectives of this research were to identify current PDA management practices among cardiologists and neonatologists in the United States, describe any significant differences in management, and describe areas where practices align.
Methods: A survey of 10 questions based on the management of PDA in ELBW infants was conducted among 100 prominent neonatologists from 74 centers and 103 prominent cardiologists from 75 centers. Among the cardiologists, approximately 50% were interventionists… More >

Jason Nathaniel Johnson^1,2, Shyam Sathanandam¹, Ronak Naik¹, Ranjit Philip¹

Congenital Heart Disease, Vol.14, No.1, pp. 74-78, 2019, DOI:10.1111/chd.12725

Abstract Echocardiographic imaging provides real‐time guidance during transcatheter patent ductus arteriosus (PDA) closure in extremely low birth weight (ELBW) infants. Transthoracic echocardiogram provides detailed assessment of the PDA and sur‐ rounding structures prior to, during, and after transcatheter closure. This article aims to review the different echocardiographic techniques and concepts utilized during transcatheter PDA closure in ELBW infants. More >

Anthony Merlocco

Congenital Heart Disease, Vol.14, No.1, pp. 100-104, 2019, DOI:10.1111/chd.12719

Abstract The ductus arteriosus (DA) has been studied since Galen. Initially after birth in neo‐ nates with obstruction to pulmonary blood flow, DA patency is integral to ensure out‐ put and oxygenation. While DA stenting dates back 25 years, there is emerging interest in better understanding how and when to utilize this strategy as an alternative to surgi‐ cal shunt placement or ongoing prostaglandin administration. Understanding the nor‐ mal fetal circulation and the perturbations that affect flow and oxygenation is integral to comprehending how normal DA anatomy and morphology may change and how this may influence… More >