VINíCIUS AUGUSTO SIMãO¹, LUIZ GUSTAVO DE ALMEIDA CHUFFA¹, LEóN FERDER², FELIPE INSERRA², WALTER MANUCHA^3,4,*

BIOCELL, Vol.48, No.10, pp. 1429-1442, 2024, DOI:10.32604/biocell.2024.053478 - 02 October 2024

Abstract The interplay between mitochondria, epigenetics, and the microbiota is intricately linked to both health and disease. Within our cells, a complex molecular dance occurs, where these components intertwine in a mesmerizing ballet that plays a decisive role in our health. Mitochondria, beyond being energy powerhouses, modulate nuclear gene expression through messengers like reactive oxidative stress (ROS) and calcium. Epigenetics, acting as the molecular conductor, regulates the expression of both nuclear and mitochondrial genes through modifications like DNA methylation. The intestinal microbiota itself produces short-chain fatty acids (SCFAs) that influence mitochondrial activity. SCFA-induced epigenetic modifications, like… More >

SHAN OU^#, YUN XU^#, QINGLAN LIU, TIANWEN YANG, WEI CHEN, XIU YUAN, XIN ZUO, PENG SHI^*, JIE YAO^*

BIOCELL, Vol.48, No.3, pp. 415-429, 2024, DOI:10.32604/biocell.2024.046178 - 15 March 2024

Abstract Background: The interrelation between intestinal polyps, metabolic syndrome (MetS), and colorectal cancer (CRC) is a critical area of study. This research focuses on pinpointing potential molecular targets to understand the link between intestinal polyp formation, metabolic irregularities, and CRC progression. Methods: We examined clinical samples from patients with intestinal polyps coexisting with MetS and compared them with samples from patients with standard intestinal polyps. Transcriptome sequencing and public database analysis were employed to identify significant pathways and genes. These targets were then validated through immunohistochemistry (IHC). Following the RNA interference of key target expression, a… More > Graphic Abstract

Abdullah B. Alansare^*

International Journal of Mental Health Promotion, Vol.26, No.1, pp. 11-20, 2024, DOI:10.32604/ijmhp.2023.044656 - 05 February 2024

Abstract Emerging evidence suggests the existence of ‘paradoxical’ relationships between domain-specific sedentary behavior (SB) and health outcomes. This study assessed the associations of total and domain-specific SB, by pattern, with symptoms of mental disorders in Saudi adults. Participants (n = 554) completed a web-based survey between January 18th, 2023 and February 5th, 2023. Total SB was measured by using the Sedentary Behavior Questionnaire. Total SB was then partitioned into leisure, occupational, and commuting SB during weekdays and on weekend days. Symptoms of mental disorders including symptoms of depression, anxiety, and stress were evaluated by using the… More >

Yiteng Zang¹, Biyun Xu², Sizhen Chen¹, Grace Mutale¹, Qiuyun Cao^3,*, Bingwei Chen^1,*

International Journal of Mental Health Promotion, Vol.25, No.12, pp. 1287-1302, 2023, DOI:10.32604/ijmhp.2023.042584 - 29 December 2023

Abstract Psychosis has increasingly become a social problem, emphasizing the need to understand the relationship between mental disorders and personality. This study aimed to investigate the relationship between mental disorders and personality among psychiatric outpatients based on real-world data. Symptom Checklist 90 (SCL-90) and Eysenck Personality Questionnaire (EPQ) were used to evaluate the personality and psychopathological symptoms of patients (n = 8409) in the Psychiatric Outpatient Department at Nanjing Drum Tower Hospital. t-test was used to compare scores between patients and national norms. Pearson’s correlation coefficient and path analysis were used to explore the relationship between mental… More >

Yichi Zhang^#, Yuxiang Feng^#, Shan Hu^*, Huiyong Fan^*

International Journal of Mental Health Promotion, Vol.25, No.12, pp. 1323-1341, 2023, DOI:10.32604/ijmhp.2023.029096 - 29 December 2023

Abstract Theoretical models have predicted a positive association between anxiety and Internet use disorders. However, the findings of previous studies are conflicting, with some reporting a positive association and others proposing no relationship between the two. To explore the true relationship between the two and analyze the reasons for the differences, 100 primary studies involving 108,539 subjects were entered into a meta-analysis. The results showed that (1) there was a significant positive correlation between students’ anxiety and Internet use disorder (r = 0.330); (2) the moderating effect of anxiety type was significant. (3) The moderating effects of More >

Namyun Kil^1,*, Jin Gun Kim², Emily Thornton¹, Amy Jeranek³

International Journal of Mental Health Promotion, Vol.25, No.10, pp. 1117-1125, 2023, DOI:10.32604/ijmhp.2023.022981 - 03 November 2023

Abstract

Mental health conditions in children and adolescents can be improved by slow mindful nature connection known as forest therapy or bathing. Forest therapy has recently received growing attention as an enabler of relaxation and preventive health care with demonstrated clinical efficacy. However, it is not well-known that forest therapy also decreases mental health issues among individuals with mental health disorders. This study explored the psychological and physiological health benefits of structured forest therapy programs for children and adolescents with mental health disorders. A one-group pre-test-posttest design was employed for our study participants. Twelve participants (aged 9–14

… More >

WAYEZ NAQVI, ANANYA SINGH, PREKSHI GARG, PRACHI SRIVASTAVA^*

BIOCELL, Vol.47, No.8, pp. 1675-1687, 2023, DOI:10.32604/biocell.2023.029624 - 28 August 2023

Abstract Biological entities are involved in complicated and complex connections; hence, discovering biological information using network biology ideas is critical. In the past few years, network biology has emerged as an integrative and systems-level approach for understanding and interpreting these complex interactions. Biological network analysis is one method for reducing enormous data sets to clinically useful knowledge for disease diagnosis, prognosis, and treatment. The network of biological entities can help us predict drug targets for several diseases. The drug targets identified through the systems biology approach help in targeting the essential biological pathways that contribute to More >

YAN ZHENG^1,2, SIHUI MA^3,4,*, KATSUHIKO SUZUKI⁴, HISANORI KATO³, HUIJUAN JIA^3,*

BIOCELL, Vol.47, No.8, pp. 1897-1906, 2023, DOI:10.32604/biocell.2023.027632 - 28 August 2023

Abstract Mental disorders such as depression and anxiety inflict significant burdens on individuals and society. Commonly prescribed treatments often involve cognitive therapy and medications. However, for patients resistant to these conventional methods, alternative therapies like the Ketogenic Diet (KD) offer a promising avenue. KD and its key metabolite, β-hydroxybutyrate (BHB), have been hypothesized to alleviate mental disorders through anti-inflammatory actions, a crucial pathway in the pathophysiology of depression. This mini-review examines 15 clinical trials exploring the influence of KD and BHB on inflammation and their potential roles in managing mental disorders. Both human and animal studies More >

Yali Qiang^*

International Journal of Mental Health Promotion, Vol.25, No.5, pp. 627-637, 2023, DOI:10.32604/ijmhp.2023.025746 - 28 April 2023

Abstract Speech disorders are a common type of childhood disease. Through experimental intervention, this study aims to improve the vocabulary comprehension levels and language ability of children with speech disorders through the language cognition and emotional speech community method. We also conduct a statistical analysis of the interventional effect. Among children with speech disorders in Dongguan City, 224 were selected and grouped according to their receptive language ability and IQ. The 112 children in the experimental group (EG) received speech therapy with language cognitive and emotional speech community, while the 112 children in the control group… More >

Mohsin Ghani, Ghulam Gilanie^*

Intelligent Automation & Soft Computing, Vol.36, No.3, pp. 2835-2847, 2023, DOI:10.32604/iasc.2023.034857 - 15 March 2023

Abstract The lungs are the main fundamental part of the human respiratory system and are among the major organs of the human body. Lung disorders, including Coronavirus (Covid-19), are among the world’s deadliest and most life-threatening diseases. Early and social distance-based detection and treatment can save lives as well as protect the rest of humanity. Even though X-rays or Computed Tomography (CT) scans are the imaging techniques to analyze lung-related disorders, medical practitioners still find it challenging to analyze and identify lung cancer from scanned images. unless COVID-19 reaches the lungs, it is unable to be… More >