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  • Open Access

    PROCEEDINGS

    Towards High-Fidelity and Efficient Computation for Diagnosis and Treatment of Cardiovascular Disease

    Lei Wang1,*, Blanca Rodriguez2, Xiaoyu Luo3, Charles Augarde4

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.30, No.4, pp. 1-2, 2024, DOI:10.32604/icces.2024.013350

    Abstract Cardiovascular disease is the leading cause of death worldwide. Disease-specific software, like FFRct from HeartFlow, and high-fidelity computational models within a general-purpose software, like Living Heart Project within Abaqus, are essential to revolutionise diagnosis and treatment of cardiovascular disease for clinicians and design of medical devices for industries. This talk presents our past researches on computational modelling of tear propagation in the aortic dissection [1-2] and of electromechanical coupling in the human heart with the finite element method [3], and our current exploration on high-fidelity and efficient computation and software development for diagnosis and treatment More >

  • Open Access

    ARTICLE

    Boundedness and Positivity Preserving Numerical Analysis of a Fuzzy-Parameterized Delayed Model for Foot and Mouth Disease Dynamics

    Muhammad Tashfeen1, Fazal Dayan1, Muhammad Aziz ur Rehman1, Thabet Abdeljawad2,3,4,5,*, Aiman Mukheimer2

    CMES-Computer Modeling in Engineering & Sciences, Vol.141, No.3, pp. 2527-2554, 2024, DOI:10.32604/cmes.2024.056269 - 31 October 2024

    Abstract Foot-and-mouth disease (FMD) is a viral disease that affects cloven-hoofed animals including cattle, pigs, and sheep, hence causing export bans among others, causing high economic losses due to reduced productivity. The global effect of FMD is most felt where livestock rearing forms an important source of income. It is therefore important to understand the modes of transmission of FMD to control its spread and prevent its occurrence. This work intends to address these dynamics by including the efficacy of active migrant animals transporting the disease from one area to another in a fuzzy mathematical modeling… More >

  • Open Access

    ARTICLE

    Transfer Learning Empowered Skin Diseases Detection in Children

    Meena N. Alnuaimi1, Nourah S. Alqahtani1, Mohammed Gollapalli2, Atta Rahman1,*, Alaa Alahmadi1, Aghiad Bakry1, Mustafa Youldash3, Dania Alkhulaifi1, Rashad Ahmed4, Hesham Al-Musallam1

    CMES-Computer Modeling in Engineering & Sciences, Vol.141, No.3, pp. 2609-2623, 2024, DOI:10.32604/cmes.2024.055303 - 31 October 2024

    Abstract Human beings are often affected by a wide range of skin diseases, which can be attributed to genetic factors and environmental influences, such as exposure to sunshine with ultraviolet (UV) rays. If left untreated, these diseases can have severe consequences and spread, especially among children. Early detection is crucial to prevent their spread and improve a patient’s chances of recovery. Dermatology, the branch of medicine dealing with skin diseases, faces challenges in accurately diagnosing these conditions due to the difficulty in identifying and distinguishing between different diseases based on their appearance, type of skin, and… More >

  • Open Access

    REVIEW

    Sodium-Glucose Cotransporter 2 Inhibitors in Adult and Pediatric Congenital Heart Disease: Review of Emerging Data and Future Directions

    William H. Marshall V1,2,*, Lydia K. Wright2

    Congenital Heart Disease, Vol.19, No.4, pp. 419-433, 2024, DOI:10.32604/chd.2024.056608 - 31 October 2024

    Abstract Heart failure (HF) is common in patients with congenital heart disease (CHD) and there are limited medical therapies. Sodium-glucose cotransporter 2 inhibitors (SGLT2i) are a proven medical therapy in patients with acquired HF, though data are limited in patients with CHD. The aim of this review is to summarize the current evidence for use of SGLT2i in patients with CHD and identify future directions for study. In available publications, SGLT2i in patients with CHD seem to be well tolerated, with similar side effect profile to patients with acquired HF. Improvement in functional capacity and natriuretic More >

  • Open Access

    REVIEW

    Right Axillary Thoracotomy Should Be the Standard of Care for Repair of Non-Complex Congenital Heart Defects in Infants and Children

    Sameh M. Said1,2,*, Yasin Essa1

    Congenital Heart Disease, Vol.19, No.4, pp. 407-417, 2024, DOI:10.32604/chd.2024.055636 - 31 October 2024

    Abstract Minimally invasive approaches for cardiac surgery in children have been lagging in comparison to the adult world. A wide range of the most common congenital heart defects in infants and children can be repaired successfully through a variety of non-sternotomy incisions. This has been shown to be associated with superior cosmetic results, shorter hospital stays, and rapid return to full activity compared to sternotomy. These approaches have been around for decades, but they have not been widely adopted for a variety of reasons. Right axillary thoracotomy is one of these approaches that we believe should More >

  • Open Access

    ARTICLE

    Standardized Management of Acute Pulmonary Hemorrhage after Percutaneous Pulmonary Vein Intervention

    Catalina Vargas-Acevedo1, Gareth J. Morgan1, Rhynn Soderstrom2, Richard Ing3, Nicholas Houska3, Jenny E. Zablah1,*

    Congenital Heart Disease, Vol.19, No.4, pp. 389-397, 2024, DOI:10.32604/chd.2024.055121 - 31 October 2024

    Abstract Introduction: Pulmonary hemorrhage (PHm) is a life-threatening complication that can occur after catheter-based interventions in patients with pulmonary vein stenosis (PVS). Inhaled racemic epinephrine (iRE) and tranexamic acid (iTXA) have been used in other conditions, but a standardized approach in PVS has not been described. We aimed to describe the current management of PHm after PVS catheter-based interventions. Methods: We present a retrospective review of episodes of PHm from July 2022 to February 2024. PHm was defined as frank blood suctioned from the endotracheal tube including blood-tinged secretions and >3% decrease in saturations and/or ventilatory… More >

  • Open Access

    REVIEW

    The Potential of Circular RNAs as Biomarkers in Pulmonary Arterial Hypertension Related to Congenital Heart Disease

    Fajri Marindra Siregar1,2, Sofia Mubarika Haryana3, Dyah Wulan Anggrahini4, Lucia Kris Dinarti4, Anggoro Budi Hartopo4,*

    Congenital Heart Disease, Vol.19, No.4, pp. 375-388, 2024, DOI:10.32604/chd.2024.054742 - 31 October 2024

    Abstract A particular type of endogenous noncoding RNAs known as circular RNAs (circRNAs) has now become possible biomarkers for several diseases because of their stability and tissue-specific expression patterns. CircRNAs might play a role in various of biological processes. The identification of particular circRNAs dysregulated in pulmonary arterial hypertension (PAH) raises the possibility of these molecules serving as biomarkers for the disease’s early diagnosis and treatment. This review mainly summarizes the role and potential of circRNA as a future biomarker in PAH related to congenital heart disease. This study presented several potential circRNA targets as diagnostic More > Graphic Abstract

    The Potential of Circular RNAs as Biomarkers in Pulmonary Arterial Hypertension Related to Congenital Heart Disease

  • Open Access

    MINI REVIEW

    Interplay between Plants and Microbial Communities: Insights from Holobionts and Environmental Interactions

    Sejin Choi1,2, Ho-Seok Lee1,2,*

    Phyton-International Journal of Experimental Botany, Vol.93, No.10, pp. 2519-2534, 2024, DOI:10.32604/phyton.2024.058012 - 30 October 2024

    Abstract Plants interact with a complex network of microorganisms, forming a dynamic holobiont that is crucial for their health, growth, and adaptation. This interconnected system is deeply influenced by environmental factors, which modulate the relationships within the plant microbiome. Key environmental drivers such as light, temperature, and moisture can alter the balance of these interactions, impacting plant immunity, resilience, and overall fitness. The traditional disease triangle model, which emphasizes plant-pathogen-environment interactions, is enhanced by incorporating the role of the microbiome, revealing how microbial communities contribute to disease outcomes. This review highlights the importance of shifting focus More >

  • Open Access

    ARTICLE

    Effects of Paclobutrazol Seed Priming on Seedlings Quality, Physiological and Bakanae Disease Index Characteristics of Rice (Oryza sativa L.)

    Hossam S. El-Beltagi1,2,*, Mohamed Fathi El-Nady3, Adel A. Rezk1,4, Abdelaziz M. Tahoon5, Mohammed I. Al-Daej1, Dina Abdulmajid6, Mohamed M. El-Mogy7, Elsayed Abd Elmaksoud Abomarzoka8, Sherif Mohamed El-Ganainy7,9, Metwaly Mahfouz Salem Metwaly3

    Phyton-International Journal of Experimental Botany, Vol.93, No.10, pp. 2535-2556, 2024, DOI:10.32604/phyton.2024.056734 - 30 October 2024

    Abstract Rice (Oryza sativa L.) is one of the most important cereal crops in the world. Bakanae disease is a significant rice disease widely distributed in rice-growing regions worldwide. Therefore, the present investigation aimed to assess the optimal concentrations of paclobutrazol (PBZ) as a treatment for rice grains (cv. Sakha 108) to control bakanae disease, also evaluating its impact on grain germination, seedling growth parameters as well as disease index. Paclobutrazol concentrations had no significant impact on seed germination, regardless of whether the seeds were incubated with Fusarium fujikuroi or not. Application of PBZ, either alone or in… More >

  • Open Access

    ARTICLE

    Enhanced Ultraviolet‑B Radiation Suppresses Magnaporthe oryzae Infection and Alleviates Its Damage to the Photosynthesis of Rice Leaves

    Qinghao Zhang1, Yijie Yang1, Jiong Wu1, Hongru Li1, Yuan Li1, Zuran Li2,*, Yongmei He1,*

    Phyton-International Journal of Experimental Botany, Vol.93, No.10, pp. 2613-2628, 2024, DOI:10.32604/phyton.2024.056014 - 30 October 2024

    Abstract In the present study, an indoor potting experiment was conducted to study the effects of enhanced UV-B radiation and Magnaporthe oryzae on the growth, stomatal structure, photosynthesis, and endogenous hormone contents of a traditional rice cultivar Baijiaolaojing in the Yuanyang terraces of Yunnan Province. In addition, the relationships between these parameters and disease indices were analyzed. We aimed to clarify the response of the photosynthetic physiology of rice under the combined stress of UV-B radiation and M. oryzae. Compared with the M. oryzae infection treatment, all the treatments, including M. oryzae infection before (MBR), simultaneously with (MSR), and after… More >

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