Home / Advanced Search

  • Title/Keywords

  • Author/Affliations

  • Journal

  • Article Type

  • Start Year

  • End Year

Update SearchingClear
  • Articles
  • Online
Search Results (70)
  • Open Access

    ARTICLE

    Chiral Copolymers of (R)-N-(1-Phenyl-Ethyl) Methacrylamide (R-NPEMAM) and 2-Hydroxy Ethyl Methacrylate (HEMA): Investigation of PhysicoChemical Behavior, Thermal Properties and Degradation Kinetics

    DIBYENDU S. BAG*, SHILPI TIWARI, AKANSHA DIXIT, KM. MEENU

    Journal of Polymer Materials, Vol.40, No.1-2, pp. 105-123, 2023, DOI:10.32381/JPM.2023.40.1-2.9

    Abstract In this paper, we report the microstructural investigation and influence of H-bonding on the thermal behavior e.g., glass transition (Tg ) and thermal degradation of chiral copolymers of (R)- N-(1-phenyl-ethyl) methacrylamide (R-NPEMAM) and 2-hydroxy ethyl methacrylate (HEMA). The Tg increases with the increase of chiral unit content in the copolymers and then attains optimum at around 25 mole % of chiral content. Thereafter it decreases with the increase of chiral content. The effect of copolymer composition and secondary interaction associated with the Hbonding on the thermal properties of these copolymers was also studied. Secondary interaction, specifically H-bonding has been interpreted… More >

  • Open Access

    REVIEW

    Hydrodynamic Cavitation Enhanced SR-Aops Degradation of Organic Pollutants in Water: A Review

    Xiufeng Zhu1,2, Jingying Wang1,*

    FDMP-Fluid Dynamics & Materials Processing, Vol.20, No.4, pp. 671-692, 2024, DOI:10.32604/fdmp.2023.045260

    Abstract

    SR-AOP (sulfate radical advanced oxidation process) is a novel water treatment method able to eliminate refractory organic pollutants. Hydrodynamic cavitation (HC) is a novel green technology, that can effectively produce strong oxidizing sulfate radicals. This paper presents a comprehensive review of the research advancements in these fields and a critical discussion of the principal factors influencing HC-enhanced SR-AOP and the mechanisms of synergistic degradation. Furthermore, some insights into the industrial application of HC/PS are also provided. Current research shows that this technology is feasible at the laboratory stage, but its application on larger scales requires further understanding and exploration. In… More > Graphic Abstract

    Hydrodynamic Cavitation Enhanced SR-Aops Degradation of Organic Pollutants in Water: A Review

  • Open Access

    ARTICLE

    Degradation of FAK-targeting by proteolytic targeting chimera technology to inhibit the metastasis of hepatocellular carcinoma

    XINFENG ZHANG1,2,#, SHUANG LI2,#, MEIRU SONG1,2, YUE CHEN3, LIANGZHENG CHANG3, ZHERUI LIU4, HONGYUAN DAI3, YUTAO WANG4, GANGQI YANG3, YUN JIANG5,6,*, YINYING LU1,2,*

    Oncology Research, Vol.32, No.4, pp. 679-690, 2024, DOI:10.32604/or.2024.046231

    Abstract Liver cancer is a prevalent malignant cancer, ranking third in terms of mortality rate. Metastasis and recurrence primarily contribute to the high mortality rate of liver cancer. Hepatocellular carcinoma (HCC) has low expression of focal adhesion kinase (FAK), which increases the risk of metastasis and recurrence. Nevertheless, the efficacy of FAK phosphorylation inhibitors is currently limited. Thus, investigating the mechanisms by which FAK affects HCC metastasis to develop targeted therapies for FAK may present a novel strategy to inhibit HCC metastasis. This study examined the correlation between FAK expression and the prognosis of HCC. Additionally, we explored the impact of… More >

  • Open Access

    ARTICLE

    Simulation and Analysis of Cascading Faults in Integrated Heat and Electricity Systems Considering Degradation Characteristics

    Hang Cui1, Hongbo Ren1,*, Qiong Wu1,2, Hang Lv1, Qifen Li1,2, Weisheng Zhou3

    Energy Engineering, Vol.121, No.3, pp. 581-601, 2024, DOI:10.32604/ee.2023.047470

    Abstract Cascading faults have been identified as the primary cause of multiple power outages in recent years. With the emergence of integrated energy systems (IES), the conventional approach to analyzing power grid cascading faults is no longer appropriate. A cascading fault analysis method considering multi-energy coupling characteristics is of vital importance. In this study, an innovative analysis method for cascading faults in integrated heat and electricity systems (IHES) is proposed. It considers the degradation characteristics of transmission and energy supply components in the system to address the impact of component aging on cascading faults. Firstly, degradation models for the current carrying… More >

  • Open Access

    ARTICLE

    E3 ubiquitin ligase CBL-B suppresses vascular endothelial cell pyroptosis and injury in intracranial aneurysm by facilitating NLRP3 degradation

    WEI ZHENG1, CHENG LIU2,*

    BIOCELL, Vol.48, No.2, pp. 293-301, 2024, DOI:10.32604/biocell.2023.044211

    Abstract Objective: Intracranial aneurysm (IA) represents a devastating disease with high rates of disability and mortality, which is initiated by dysfunction of endothelial cells (ECs). Evidence suggests the dysregulation of the E3 ubiquitin ligase family during EC injury. In this work, the role of an E3 ubiquitin ligase, casitas B lymphoma-B (CBL-B), was explored in human brain microvascular EC (HBMEC) function through the NLRP3 pathway. Methods: In vitro IA model was induced by treating HBMECs with oxidized low-density lipoprotein (ox-LDL). The levels of CBL-B and pyroptosis-related proteins NLRP3, ASC, cleaved caspase-1, and GSDME-N were determined by real-time-quantitative polymerase chain reaction and… More >

  • Open Access

    ARTICLE

    A Degradation Type Adaptive and Deep CNN-Based Image Classification Model for Degraded Images

    Huanhua Liu, Wei Wang*, Hanyu Liu, Shuheng Yi, Yonghao Yu, Xunwen Yao

    CMES-Computer Modeling in Engineering & Sciences, Vol.138, No.1, pp. 459-472, 2024, DOI:10.32604/cmes.2023.029084

    Abstract Deep Convolutional Neural Networks (CNNs) have achieved high accuracy in image classification tasks, however, most existing models are trained on high-quality images that are not subject to image degradation. In practice, images are often affected by various types of degradation which can significantly impact the performance of CNNs. In this work, we investigate the influence of image degradation on three typical image classification CNNs and propose a Degradation Type Adaptive Image Classification Model (DTA-ICM) to improve the existing CNNs’ classification accuracy on degraded images. The proposed DTA-ICM comprises two key components: a Degradation Type Predictor (DTP) and a Degradation Type… More >

  • Open Access

    PROCEEDINGS

    Uncovering the Intrinsic Deficiencies of Phase-Field Modeling for Dynamic Fracture

    Jiale Ji1,*, Mengnan Zhang1

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.27, No.2, pp. 1-1, 2023, DOI:10.32604/icces.2023.09632

    Abstract The phase-field fracture (PFF) approach has achieved great triumphs in modeling quasi-static fracture. Nevertheless, its reliability in serving dynamic fractures still leaves something to be desired, such as the prediction of the limiting crack velocity. Using a pre-strained fracture configuration, we discovered a disturbing phenomenon that the crack limiting speed identified by the dynamic PFF model is not related to the specific material, which seriously deviates from the experimental observation. To ascertain the truth, we first ruled out the correlation between the limiting crack velocity on the phase-field characteristic scale and external loading. Afterward, by switching between different crack surface… More >

  • Open Access

    PROCEEDINGS

    Measuring the Tensile Strength Degradations of Mineral Grain Interfaces (MGIs) in the Granite After Thermo-hydro-mechanical (THM) Coupling

    Mengyi Li1, Zhijun Wu1,*

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.25, No.1, pp. 1-2, 2023, DOI:10.32604/icces.2023.09829

    Abstract Buried in depth for decades of years, granite in the deep geological repository will be subjected to extremely complex effects of thermo-hydro-mechanical (THM) treatment, and the tensile strengths of mineral grain interfaces (MGIs) are inevitably impacted by the THM treatment [1, 2]. Originated by the failure modes of granite after THM treatment, the tensile strength of MGI plays an important role in determining the macro mechanical properties of THM-treated granite [3, 4]. However, the accurate characterization of the tensile strength degradations of MGIs with THM treatment is still lacking. In this study, the varied tensile strengths of MGIs, including the… More >

  • Open Access

    ARTICLE

    Identification of microbial metabolites that accelerate the ubiquitin-dependent degradation of c-Myc

    ZIYU LIU1,2, AKIKO OKANO3,4, EMIKO SANADA1,3,4, YUSHI FUTAMURA3,4, TOSHIHIKO NOGAWA3,5, KOSUKE ISHIKAWA6, KENTARO SEMBA7,8, JIANG LI9, XIAOMENG LI10, HIROYUKI OSADA3,4,11,*, NOBUMOTO WATANABE1,2,4,*

    Oncology Research, Vol.31, No.5, pp. 655-666, 2023, DOI:10.32604/or.2023.030248

    Abstract

    Myc belongs to a family of proto-oncogenes that encode transcription factors. The overexpression of c-Myc causes many types of cancers. Recently, we established a system for screening c-Myc inhibitors and identified antimycin A by screening the RIKEN NPDepo chemical library. The specific mechanism of promoting tumor cell metastasis by high c-Myc expression remains to be explained. In this study, we screened approximately 5,600 microbial extracts using this system and identified a broth prepared from Streptomyces sp. RK19-A0402 strongly inhibits c-Myc transcriptional activity. After purification of the hit broth, we identified compounds closely related to the aglycone of cytovaricin and had… More > Graphic Abstract

    Identification of microbial metabolites that accelerate the ubiquitin-dependent degradation of c-Myc

  • Open Access

    ARTICLE

    Effect of PEG Incorporation on Physicochemical and in vitro Degradation of PLLA/PDLLA Blends: Application in Biodegradable Implants

    Mochamad Chalid1,*, Gifrandy Gustiraharjo1, Azizah Intan Pangesty1, Alyssa Adyandra1, Yudan Whulanza2, Sugeng Supriadi2

    Journal of Renewable Materials, Vol.11, No.7, pp. 3043-3056, 2023, DOI:10.32604/jrm.2023.026788

    Abstract Polyethylene glycol (PEG) was added at different concentrations to the blend of poly(L-lactic acid) (PLLA) and poly(D,L-lactic acid)(PDLLA) to tailor the properties. The differential scanning calorimetry (DSC) measurement showed that all blends were miscible due to shifting a single glass transition temperature into a lower temperature for increasing PEG content. The DSC, FTIR, and XRD results implied the crystallinity enhancement for PEG content until 8 wt%, then decreased at 12 wt% PEG. The XRD result indicated the homo crystalline phase formation in all blends and no stereocomplex crystal. The in vitro degradation study indicated that PEG content is proportional to… More > Graphic Abstract

    Effect of PEG Incorporation on Physicochemical and <i>in vitro</i> Degradation of PLLA/PDLLA Blends: Application in Biodegradable Implants

Displaying 1-10 on page 1 of 70. Per Page