Enrico Mini^*, Ida Landini^*, Laura Lucarini^†, Andrea Lapucci^*, Cristina Napoli^‡, Gabriele Perrone^*, Renato Tassi^*, Emanuela Masini^†, Flavio Moroni^†, Stefania Nobili^‡

Oncology Research, Vol.25, No.9, pp. 1441-1451, 2017, DOI:10.3727/096504017X14926854178616

Abstract The poly(ADP-ribose) polymerase (PARP) enzymes play a key role in the regulation of cellular processes (e.g., DNA damage repair, genomic stability). It has been shown that PARP inhibitors (PARPIs) are selectively cytotoxic against cells having dysfunctions in genes involved in DNA repair mechanisms (synthetic lethality). Drug-induced PARP inhibition potentiates the activity of anticancer drugs such as 5-fluorouracil in enhancing DNA damage, whose repair involves PARP-1 activity. The aim of this study was to evaluate the inhibitory effects of a novel PARPI, HYDAMTIQ, on growth in human tumor cell lines characterized by different features with regard… More >

Jing Xiao^*, Guang Li^†, Jingyu Zhou^‡, Shalong Wang^‡, Dongcai Liu^‡, Guoshun Shu^‡, Jianping Zhou^‡, Feng Ren^‡

Oncology Research, Vol.26, No.4, pp. 593-604, 2018, DOI:10.3727/096504017X14920318811712

Abstract MicroRNAs (miRs), a class of small noncoding RNAs, are important regulators for gene expression through directly binding to the 3'-untranslated region (3'-UTR) of their target mRNA. Recently, downregulation of miR-520b has been observed in several common human cancers. However, the exact role of miR-520b in colorectal cancer (CRC) has not previously been studied. In this study, our data showed that miR-520b was significantly downregulated in CRC and cell lines when compared with adjacent normal tissues and a normal intestinal epithelial cell line. Low expression of miR-520b was notably associated with the malignant progress and a… More >

Enrico Mini^*, Ida Landini^*, Laura Lucarini^†, Andrea Lapucci^*, Cristina Napoli^‡, Gabriele Perrone^*, Renato Tassi^*, Emanuela Masini^†, Flavio Moroni^†, Stefania Nobili^‡

Oncology Research, Vol.26, No.2, pp. 333-334, 2018, DOI:10.3727/096504018X15187172557369

Abstract The poly(ADP-ribose) polymerase (PARP) enzymes play a key role in the regulation of cellular processes (e.g., DNA damage repair, genomic stability). It has been shown that PARP inhibitors (PARPIs) are selectively cytotoxic against cells having dysfunctions in genes involved in DNA repair mechanisms (synthetic lethality). Drug-induced PARP inhibition potentiates the activity of anticancer drugs such as 5-fluorouracil in enhancing DNA damage, whose repair involves PARP-1 activity. The aim of this study was to evaluate the inhibitory effects of a novel PARPI, HYDAMTIQ, on growth in human tumor cell lines characterized by different features with regard… More >

Norah Abdullah Al-Johany^1,*, Sanaa Abdullah Sharaf^1,2, Fathy Elbouraey Eassa^1,2, Reem Abdulaziz Alnanih^1,2,*

CMC-Computers, Materials & Continua, Vol.79, No.2, pp. 3139-3173, 2024, DOI:10.32604/cmc.2024.047392

Abstract The Message Passing Interface (MPI) is a widely accepted standard for parallel computing on distributed memory systems. However, MPI implementations can contain defects that impact the reliability and performance of parallel applications. Detecting and correcting these defects is crucial, yet there is a lack of published models specifically designed for correcting MPI defects. To address this, we propose a model for detecting and correcting MPI defects (DC_MPI), which aims to detect and correct defects in various types of MPI communication, including blocking point-to-point (BPTP), nonblocking point-to-point (NBPTP), and collective communication (CC). The defects addressed by… More >

Xiao Lu^1,*, Chengling Jiang¹, Zhoujun Ma¹, Haitao Li², Yuexin Liu²

CMC-Computers, Materials & Continua, Vol.79, No.1, pp. 373-390, 2024, DOI:10.32604/cmc.2024.047469

Abstract Insulator defect detection plays a vital role in maintaining the secure operation of power systems. To address the issues of the difficulty of detecting small objects and missing objects due to the small scale, variable scale, and fuzzy edge morphology of insulator defects, we construct an insulator dataset with 1600 samples containing flashovers and breakages. Then a simple and effective surface defect detection method of power line insulators for difficult small objects is proposed. Firstly, a high-resolution feature map is introduced and a small object prediction layer is added so that the model can detect… More >

Kechen Song^1,2,*, Wenqi Cui², Han Yu¹, Xingjie Li¹, Yunhui Yan^2,*

CMC-Computers, Materials & Continua, Vol.78, No.3, pp. 3953-3969, 2024, DOI:10.32604/cmc.2024.048451

Abstract Segment Anything Model (SAM) is a cutting-edge model that has shown impressive performance in general object segmentation. The birth of the segment anything is a groundbreaking step towards creating a universal intelligent model. Due to its superior performance in general object segmentation, it quickly gained attention and interest. This makes SAM particularly attractive in industrial surface defect segmentation, especially for complex industrial scenes with limited training data. However, its segmentation ability for specific industrial scenes remains unknown. Therefore, in this work, we select three representative and complex industrial surface defect detection scenarios, namely strip steel More >

Sureka Sivavelu, Venkatesh Palanisamy^*

CMC-Computers, Materials & Continua, Vol.78, No.3, pp. 3469-3487, 2024, DOI:10.32604/cmc.2024.047407

Abstract The development of defect prediction plays a significant role in improving software quality. Such predictions are used to identify defective modules before the testing and to minimize the time and cost. The software with defects negatively impacts operational costs and finally affects customer satisfaction. Numerous approaches exist to predict software defects. However, the timely and accurate software bugs are the major challenging issues. To improve the timely and accurate software defect prediction, a novel technique called Nonparametric Statistical feature scaled QuAdratic regressive convolution Deep nEural Network (SQADEN) is introduced. The proposed SQADEN technique mainly includes… More >

Pu Zhang¹, Yingjun Li¹, Xinyu Zhu¹, Shizhan Xu¹, Pinwu Guan^1,*, Wei Liu², Yanwei Guo², Haibo Wang²

Structural Durability & Health Monitoring, Vol.18, No.2, pp. 143-159, 2024, DOI:10.32604/sdhm.2024.046986

Abstract Grouting defects are an inherent challenge in construction practices, exerting a considerable impact on the operational structural integrity of connections. This investigation employed the impact-echo technique for the detection of grouting anomalies within connections, enhancing its precision through the integration of wavelet packet energy principles for damage identification purposes. A series of grouting completeness assessments were meticulously conducted, taking into account variables such as the divergent material properties of the sleeves and the configuration of adjacent reinforcement. The findings revealed that: (i) the energy distribution for the high-strength concrete cohort predominantly occupied the frequency bands More >

Sipawath Khamplod^1,2, Yodying Kaolawanich^1,2, Khemajira Karaketklang³, Nithima Ratanasit^1,2,*

Congenital Heart Disease, Vol.19, No.1, pp. 93-105, 2024, DOI:10.32604/chd.2024.048631

Abstract Background: Atrial septal defect (ASD) is a common form of adult congenital heart disease that can lead to long-term adverse outcomes if left untreated. Early closure of ASD has been associated with excellent outcomes and lower complication rates. However, there is limited evidence regarding the prognosis of ASD closure in older adults. This study aims to evaluate the mortality rates in older ASD patients with and without closure. Methods: A retrospective cohort study was conducted on patients aged 40 years or older with ASD between 2001 and 2017. Patients were followed up to assess all-cause… More > Graphic Abstract

Yücel Kaya^1,*, And Yavuz¹, Hasan Berkan Sayal¹, Büşra Tsakir¹, Gökalp Kabacaoğlu¹, Kadriye Nilay Özcan²

Congenital Heart Disease, Vol.19, No.1, pp. 123-129, 2024, DOI:10.32604/chd.2024.048145

Abstract Congenital ventricular aneurysm is a very rare cardiac anomaly. A diagnosis can be made during the prenatal period using fetal echocardiography. This study presents a very rare apically located left ventricular aneurysm case, and the relevant literature was reviewed and discussed. In this case, a 35-year-old, gravida 2, parity 1 pregnant woman at 24 weeks of gestation, displayed a wide aneurysmal image in the left ventricular apical wall on fetal echocardiography. There was a 1.79 mm muscular ventricular septal defect at the apical region of the interventricular septum. In the course of the color Doppler More >