Kamila Mozga¹, Olga Synowiecka¹, Igor Rydzyk¹, Anna Marek¹, Ewelina Wieczorek¹, Alicja Petniak^2,*, Paulina Gil-Kulik²

Oncology Research, Vol.34, No.2, 2026, DOI:10.32604/or.2025.070505 - 19 January 2026

Abstract Objectives: Immunotherapy based on immune checkpoint blockade (ICB) has become a key treatment for melanoma. However, the increasing number of cases of melanoma resistant to immunotherapy highlights the need to develop methods to overcome this resistance. This study aims to collect the most recent information on melanoma immunotherapy, discuss potential strategies to overcome resistance to immunotherapy, and identify areas that require further analysis. Methods: To achieve this goal, scientific publications from 2021–2024 available in PubMed and Google Scholar databases were analyzed. The databases were searched using the following terms: “melanoma”, “immunotherapy”, “Immune Checkpoint Blockade”, and More >

Ruiyang Han¹, Tingting Xu^1,*, Yin Shi², Wuyi Liu³

International Journal of Mental Health Promotion, Vol.26, No.9, pp. 731-744, 2024, DOI:10.32604/ijmhp.2024.054884 - 20 September 2024

Abstract Background: College students face significant academic and physiological changes, making them more susceptible to psychological issues such as depression, self-injury, and suicidal ideation. Feelings of defeat can exacerbate these risks by increasing academic stress. However, interpersonal relationships can moderate the impact of academic stress on students’ mental health. Utilizing the presage–process–product model, this study aims to empirically investigate how feelings of defeat influence depression, self-injury, and suicidal ideation among college students. Additionally, it explores the mediating role of academic stress and the moderating role of various types of interpersonal relationships. Methods: A total of 1612… More >

Mohammed Baz¹, Sabita Khatri², Abdullah Baz³, Hosam Alhakami⁴, Alka Agrawal², Raees Ahmad Khan^2,*

Computer Systems Science and Engineering, Vol.40, No.2, pp. 691-702, 2022, DOI:10.32604/csse.2022.019079 - 09 September 2021

Abstract The rapid emergence of novel virus named SARS-CoV2 and unchecked dissemination of this virus around the world ever since its outbreak in 2020, provide critical research criteria to assess the vulnerabilities of our current health system. The paper addresses our preparedness for the management of such acute health emergencies and the need to enhance awareness, about public health and healthcare mechanisms. In view of this unprecedented health crisis, distributed ledger and AI technology can be seen as one of the promising alternatives for fighting against such epidemics at the early stages, and with the higher… More >