Yue Cao^1,2, Longsheng Bao¹, Xiaowei Zhang^1,*, Zhanfei Wang¹, Bingqian Li¹

Structural Durability & Health Monitoring, Vol.18, No.4, pp. 485-503, 2024, DOI:10.32604/sdhm.2024.049698

Abstract This study addresses the issue of inaccurate single damage fingerprint recognition during the process of bridge damage identification. To improve accuracy, the proposed approach involves fusing displacement mode difference and curvature mode difference data for single damage identification, and curvature mode difference and displacement mode wavelet coefficient difference data for two damage identification. The methodology begins by establishing a finite element model of the cable-stayed bridge and obtaining the original damage fingerprints, displacement modes, curvature modes, and wavelet coefficient differences of displacement modes through modal analysis. A fusion program based on the D-S evidence theory… More > Graphic Abstract

Xiangmiao Wan, Yan Tan^*, Xiong Long

Structural Durability & Health Monitoring, Vol.18, No.4, pp. 505-524, 2024, DOI:10.32604/sdhm.2024.049363

Abstract In this study, we assessed the impact of substituting natural fine aggregates with municipal solid waste incineration bottom ash (MSWI-BA) in steel fiber (SF)-reinforced concrete on its compressive properties post high-temperature exposure. The concrete specimens incorporating MSWI-BA as the fine aggregate and SFs for reinforcement underwent uniaxial compression tests after exposure to high temperatures. Through the tests, we investigated the impact of high-temperature exposure on mechanical properties, such as mass loss rate, stress-strain full curve, compressive strength, peak strain, elastic modulus, and so on, over different thermostatic durations. The analysis revealed that with the increasing… More >

Chengpeng Zhang, Junfeng Shi^*, Caiping Huang

Structural Durability & Health Monitoring, Vol.18, No.4, pp. 465-483, 2024, DOI:10.32604/sdhm.2024.048705

Abstract In this paper, an intelligent damage detection approach is proposed for steel-concrete composite beams based on deep learning and wavelet analysis. To demonstrate the feasibility of this approach, first, following the guidelines provided by relevant standards, steel-concrete composite beams are designed, and six different damage incidents are established. Second, a steel ball is used for free-fall excitation on the surface of the steel-concrete composite beams and a low-temperature-sensitive quasi-distributed long-gauge fiber Bragg grating (FBG) strain sensor is used to obtain the strain signals of the steel-concrete composite beams with different damage types. To reduce the… More >

Enrico Mini^*, Ida Landini^*, Laura Lucarini^†, Andrea Lapucci^*, Cristina Napoli^‡, Gabriele Perrone^*, Renato Tassi^*, Emanuela Masini^†, Flavio Moroni^†, Stefania Nobili^‡

Oncology Research, Vol.25, No.9, pp. 1441-1451, 2017, DOI:10.3727/096504017X14926854178616

Abstract The poly(ADP-ribose) polymerase (PARP) enzymes play a key role in the regulation of cellular processes (e.g., DNA damage repair, genomic stability). It has been shown that PARP inhibitors (PARPIs) are selectively cytotoxic against cells having dysfunctions in genes involved in DNA repair mechanisms (synthetic lethality). Drug-induced PARP inhibition potentiates the activity of anticancer drugs such as 5-fluorouracil in enhancing DNA damage, whose repair involves PARP-1 activity. The aim of this study was to evaluate the inhibitory effects of a novel PARPI, HYDAMTIQ, on growth in human tumor cell lines characterized by different features with regard… More >

Fei Li^*1, Bin Liu^†1, Xiaolan Zhou^*, Quan Xu^‡

Oncology Research, Vol.26, No.9, pp. 1365-1373, 2018, DOI:10.3727/096504018X15154085345907

Abstract DNA damage response induced by ionizing radiation (IR) is an important event involved in the sensitivity and efficiency of radiotherapy in human medulloblastoma. RNF8 is an E3 ubiquitin ligase and has key roles in the process of DNA damage and repair. Our study aimed to evaluate the effect of RNF8 in the DNA damage repair induced by IR exposure in medulloblastoma cells. We found that the levels of RNF8 were significantly upregulated by γ-ray irradiation in a dose-dependent manner in medulloblastoma cells and colocalized with γ-H2AX, a sensitive marker of DNA double-strand breaks induced by… More >

Enrico Mini^*, Ida Landini^*, Laura Lucarini^†, Andrea Lapucci^*, Cristina Napoli^‡, Gabriele Perrone^*, Renato Tassi^*, Emanuela Masini^†, Flavio Moroni^†, Stefania Nobili^‡

Oncology Research, Vol.26, No.2, pp. 333-334, 2018, DOI:10.3727/096504018X15187172557369

Abstract The poly(ADP-ribose) polymerase (PARP) enzymes play a key role in the regulation of cellular processes (e.g., DNA damage repair, genomic stability). It has been shown that PARP inhibitors (PARPIs) are selectively cytotoxic against cells having dysfunctions in genes involved in DNA repair mechanisms (synthetic lethality). Drug-induced PARP inhibition potentiates the activity of anticancer drugs such as 5-fluorouracil in enhancing DNA damage, whose repair involves PARP-1 activity. The aim of this study was to evaluate the inhibitory effects of a novel PARPI, HYDAMTIQ, on growth in human tumor cell lines characterized by different features with regard… More >

HYUNHO KIM¹, UIJU CHO², SOOK HEE HONG³, HYUNG SOON PARK¹, IN-HO KIM³, HO JUNG AN¹, BYOUNG YONG SHIM¹, JIN HYOUNG KANG^3,*

Oncology Research, Vol.32, No.6, pp. 1021-1030, 2024, DOI:10.32604/or.2024.048919

Abstract Background: Apolipoprotein B mRNA editing catalytic polypeptide (APOBEC), an endogenous mutator, induces DNA damage and activates the ataxia telangiectasia and Rad3-related (ATR)-checkpoint kinase 1 (Chk1) pathway. Although cisplatin-based therapy is the mainstay for muscle-invasive bladder cancer (MIBC), it has a poor survival rate. Therefore, this study aimed to evaluate the efficacy of an ATR inhibitor combined with cisplatin in the treatment of APOBEC catalytic subunit 3B (APOBEC3B) expressing MIBC. Methods: Immunohistochemical staining was performed to analyze an association between APOBEC3B and ATR in patients with MIBC. The APOBEC3B expression in MIBC cell lines was assessed… More >

Chaozhi Cai^*, Xiaoyu Guo, Yingfang Xue, Jianhua Ren

Structural Durability & Health Monitoring, Vol.18, No.3, pp. 321-339, 2024, DOI:10.32604/sdhm.2024.045831

Abstract Bleachers play a crucial role in practical engineering applications, and any damage incurred during their operation poses a significant threat to the safety of both life and property. Consequently, it becomes imperative to conduct damage diagnosis and health monitoring of bleachers. The intricate structure of bleachers, the varied types of potential damage, and the presence of similar vibration data in adjacent locations make it challenging to achieve satisfactory diagnosis accuracy through traditional time-frequency analysis methods. Furthermore, field environmental noise can adversely impact the accuracy of bleacher damage diagnosis. To enhance the accuracy and anti-noise capabilities… More > Graphic Abstract

Haixia Kou^1,*, Bowen Yang¹, Xuyao Zhang², Xiaobo Yang¹, Haibo Zhao¹

Structural Durability & Health Monitoring, Vol.18, No.3, pp. 277-297, 2024, DOI:10.32604/sdhm.2024.045023

Abstract Given the difficulty in accurately evaluating the fatigue performance of large composite wind turbine blades (referred to as blades), this paper takes the main beam structure of the blade with a rectangular cross-section as the simulation object and establishes a composite laminate rectangular beam structure that simultaneously includes the flange, web, and adhesive layer, referred to as the blade main beam sub-structure specimen, through the definition of blade sub-structures. This paper examines the progressive damage evolution law of the composite laminate rectangular beam utilizing an improved 3D Hashin failure criterion, cohesive zone model, B-K failure More > Graphic Abstract

AL-Bukhaiti Khalil¹, Yanhui Liu^1,*, Shichun Zhao¹, Daguang Han²

Structural Durability & Health Monitoring, Vol.18, No.3, pp. 223-254, 2024, DOI:10.32604/sdhm.2024.044751

Abstract This study provides a comprehensive analysis of collision and impact problems’ numerical solutions, focusing on geometric, contact, and material nonlinearities, all essential in solving large deformation problems during a collision. The initial discussion revolves around the stress and strain of large deformation during a collision, followed by explanations of the fundamental finite element solution method for addressing such issues. The hourglass mode’s control methods, such as single-point reduced integration and contact-collision algorithms are detailed and implemented within the finite element framework. The paper further investigates the dynamic response and failure modes of Reinforced Concrete (RC)… More >